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The Korean Journal of Pathology 1993;27(6): 666-669.
Pleomorphic Xanthoastrocytoma: A Case Report.
Seong Ki Min, Dong Wook Kang, Kyu Sang Song, Dae Young Kang, Seong Ho Kim
1Department of Pathology, Chungnam National University, Medical College, Daejeon, Korea.
2Department of Neurosurgery, Chungnam National University, Medical College, Daejeon, Korea.
Pleomorphic xanthoastrocytoma is histologically characterized by marked cellular pleomorphism of lipid-laden neoplastic astrocytes and bizarre giant cells showing mitotic figures and high cellularity. Inspite of its ominous-looking microscopic features, howerver, the prognosis is usually favorable. This tumor develops mainly in the supratentorial area of young people and frequently involves the leptomeninges. We experienced a case of pleomorphic xanthoastrocytoma in 18 year-old-male. In addition to the cellular pleomophism, the prominent reticulin fibers surround the individual tumor cells or the tumor cells nests. Immunohistochemical staining and electron microscopy revealed glial fibrillary acidic protein(GFAP) expression and pericytoplasmic basal lamina in the tumor cells.
Key Words: Pleomorphic xanthoastrocytoma; GFAP expression; Basal lamina; Reticulin fibers
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