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The Korean Journal of Pathology 1994;28(5): 547-549.
Pulmonary Alveolar Proteinosis accompanied by Osseous Metaplasia: A case report.
Ae Ree Kim, Hyun I Cho, Han Kyeom Kim, Jong Sang Choi, In Sun Kim
Department of Anatomic Pathology, Korea University Hospital, Seoul, Korea.
The authors experienced a case of pulmonary alveolar proteinosis. A 58-year-old woman presented with 6 months duration of cough sputum and multiple patch mottled densities in both lung fields. Major histologic finding was filling of the alveoli by Periodic-Acid-Schiff-positive proteinaceous material with maintenance of normal alveolar architecture. Osseous metaplasia was seen in the alveolar space, focally. Ultrastructural study revealed numerous lamellar bodies in alveolar spaces. The immunohistochemical study using antibody to surfactant apoprotein revealed positive reaction in proteinaceous material.
Key Words: Pulmonary alveolar proteinosis; osseous metaplasia