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The Korean Journal of Pathology 1995;29(2): 251-255.
Atypical Nodule Arising in a Hepatocellular Adenoma.
Kun Chang Song, Young Nyun Park, Chanil Park
Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
This report presents a case of an atypical nodule arising in a hepatocellular adenoma(HCA) in a non-cirrhotic liver of a 42-year-old man. The patient had been relatively healthy until he developed right upper abdominal pain. Abdominal sonography and computerized tomogram revealed a 7.5x7cm sized mass in the right inferior segment of liver. The mass revealed the histologic features of HCA. At near center of the HCA, was found a I cm sized discrete nodule, a nodule within a nodule. The nodule revealed higher cellularity than the HCA and was composed of monotonous hepatocytes with an increased nuclear-cytoplasmic ratio, resembling atypical adenomatous hyperplasia. Interestingly, the atypical nodule showed a focal pseudoacinar arrangement of tumor cells. The histologic features of the atypical nodule arising in HCA may the morphological sequence of transformation from HCA to hepatocellular carcinoma
Key Words: Liver; Hepatocellular adenoma; Atypical nodule within a nodule; Hepatocellular carcinoma