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The Korean Journal of Pathology 1995;29(6): 804-806.
Interfollicular Hodgkin's Lymphoma: A case report.
Lee So Maeng, Kyung Mee Kim, You Mee Kang, Chang Seok Kang, Sang In Shim
1Department of Clinical Pathology, Catholic University Medical College, Seoul, Korea.
2Department of Pathology, Seongae Hospital, Korea.
An unusual pattern of focal involvement of lymph nodes by Hodgkin's disease is described using the name Interfollicular Hodgkin's Disease. It is characterized by florid reactive follicular hyperplasia which overshadows involvement of the interfollicular zones by Hodgkin's desease. The importance of interfollicular Hodgkin's disease rests on its misdiagnosis as a benign lesion. We report a case of interfollicular Hodgkin's disease in a 34-year-old female patient in the inguinal area. The lymph nodes showed reactive follicular hyperplasia. The focal interfollicular spaces were invaded by Hodgkin's disease. The Reed-Stemberg cells stained positively with CD15 and CD30 antibody in the immunohistochemical stain. An in situ hybridization study looking for EBV was negative in these R-S cells.
Key Words: Hodgkin's disease; Interfollicular; Immunohistochemical; In situ hybridization
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