Warning: mkdir(): Permission denied in /home/virtual/lib/view_data.php on line 81

Warning: fopen(upload/ip_log/ip_log_2024-11.txt): failed to open stream: No such file or directory in /home/virtual/lib/view_data.php on line 83

Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84
Large Cell Neuroendocrine Carcinoma of the Lung 2 cases including one presented as an ovarian mass.
Skip Navigation
Skip to contents

J Pathol Transl Med : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > J Pathol Transl Med > Volume 31(3); 1997 > Article
Original Article Large Cell Neuroendocrine Carcinoma of the Lung 2 cases including one presented as an ovarian mass.
Yun Jung Kim, Jung Weon Shim, Hye Kyung Ahn, Young Euy Park
Journal of Pathology and Translational Medicine 1997;31(3):257-262
DOI: https://doi.org/
Department of Pathology, College of Medicine, Hallym University, Seoul 150-071, Korea.
prev next
  • 1,787 Views
  • 12 Download
  • 0 Crossref
  • 0 Scopus

Pulmonary tumors exhibiting neuroendocrine differentiation are classified as typical carcinoid, atypical carcinoid, and small cell lung carcinoma(SCLC). Travis et al. proposed a fourth category of large cell neuroendocrine carcinoma, which is characterized by light microscopic neuroendocrine appearance, cells of large size, polygonal shape, low nuclear cytoplasmic ratio, coarse nuclear chromatin, with prominent nucleoli high mitotic rate and frequent necrosis; and neuroendocrine features by immunohistochemistry or electron microscopy. High grade neuroendocrine carcinoma (LCAC-NE) revealed aggressive clinical course. We report two cases of neuroendocrine tumors of the lung characterized by a trabecular pattern of large pleomorphic cells with frequent mitoses and wide necrosis. The frequent metastatic sites of atypical carcinoid were liver, bone and brain. One of our case is presented, at first, as an ovarian mass, which shows multifocal rosettes and revealed metastasis from lung. Both cases expressed neuroendocrine differentiation by light microscopy and immunohistochemistry. However clinical neuroendocrine symptom were not present.

Related articles

J Pathol Transl Med : Journal of Pathology and Translational Medicine
TOP