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The Effect of Cortisone on Transformation of Sensitized Allogenic Rabbit Thoracic Lymphocytes in Diffusion Chamber
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HOME > J Pathol Transl Med > Volume 7(1); 1973 > Article
Etc The Effect of Cortisone on Transformation of Sensitized Allogenic Rabbit Thoracic Lymphocytes in Diffusion Chamber
Journal of Pathology and Translational Medicine 1973;7(1):63-69
DOI: https://doi.org/
Department of Pathology, Catholic Medical College, Seoul, Korea
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The method of diffusion chamber cultivation was found to be appropriate to observe the potentialities of lymphocytes (Schelton & Rice, 1959 ; Schooley & Berman, 1960 ; Holub, 1958, 1960, 1962), The possibility of separating practically pure suspensions of small thoracic duct lymphocytes enabled us to observe directly the nature of these cells. Holub confirmed that the small lymphocytes from rabbit thoracic duct lymph cells were found capable of being changed to antibody-producing plasmacytoid cells morphologically and functionally when homotransplanted either with or without protein antigen. Bai & Kim (1972) observed the effect of cortisone on the transformation of autologous small lymphocyte of rabbit in diffusion chamber inserted intraperitoneally and confirmed that there was transformation of small lymphocyte into blastic form. Park and Kim (1972) reported allogeneic thoracic lymphocytes in diffusion chamber in cortisone treated rabbits were transformed to blastic form. We made an attempt to observe the effect of cortisone on transformation of eggalbumin sensitized allogeneic rabbit thoracic lymphocyte in diffusion chamber following resensitization. The results were as follows : Sensitized allogeneic thoracic lymphocytes in diffusion chamber were decreased in total number following challenge either by means of intraperitoneal injection or local administration of the same antigen respectively, and/or following those treatment plus injection of cortisone. The transformations into blastic forms were prominent only of the lymphocytes in the challenged group by means of intraperitoneal injection of the same antigen.

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