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HOME > J Pathol Transl Med > Volume 9(2); 1975 > Article
Etc The Changes of Endothelial Cells in Rat Lung Alveoli Induced by Carbon Monoxide Poisoning
Journal of Pathology and Translational Medicine 1975;9(2):131-135
DOI: https://doi.org/
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Department of Pathology, Kyungpook National University School of Medicine, Taegu, Korea

The blood capillaries of alveolar wall were the route of gas exchange, so that some morphologic and functional changes were suspected in these capillaries in case of altered gas exchange states, such as carbon monoxide poisoning. This study was carried out to investigate the morphologic alteration in these capillaries. Rabbits were forced to inhalate 0.2% CO gas for 2 hours (3 animals) and 4 hours (3 animals) and 0.1% CO gas for 2 hours daily for 5 days respectively. The lungs were extracted out and observed by the electron microscope. Results were summarized as follow: Pinocytotic vesicles were increased in number with occasional large vacuole formation. Also noted were increase of lysosome, swelling of mitochondria with loss of crests, dilatation of interendothelial gap and irregularity of plasma membrane. No significant change was noted in the nuclei. The results suggested that CO poisoning induced increased permeability with degenerative changes of the endothelial cells, although these cells could easily contact to oxygen of alveolarlumen.

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