Cryptococcosis occurs throughout the world. The respiratory tract is the only known Portal of entry into the body. Cryptococcosis often manifest itself as a widespread systemic disease with prominent involvement of the brain and meninges, and the presence of the fungus in the spinal fluid. Cutaneous lesions are found in 10 to 15 percent of the cases of systemic cryptococcosis. A case of cutaneous cryptococcosis found in a 68 years old female patient associated with probable malignant lymphoma. Several small subcutaneous nodules developed about one week before the beginning of the meningeal signs. By repeated cultures and india ink preparation of the cerebrospinal fluid, many Cryptococcus neoformans were identified.