A 70 year-old Korean male was admitted to Dept. of Dermatology, because of generalized erythematous match head sized papules with itching sensation for 45 days. Physical examination revealed palpable axillary, inguinal and left subclavicu1ar lymph nodes, and slight hepatomegaly. Peripheral blood findings showed marked eosinophilia (up to 41%) and a few atypical monocytoid cells. Multiple skin biopsies revealed malignant histiocytosis with cutaneous involvement. He was treated with oncovin and prednisolone, and skin lesions and hematologic abnormalities were considerably improved. But the patient was died on 38th hospital day. On autopsy, the lesions were systemic, showing diffuse proliferation of atypical histiocytes with atypical giant cell formation in spleen, lymph nodes, lung, bone marrow and skin. However, erythrophagocytosis of these atypical histiocytes was not seen.