Abstract

The author investigated changes of serum protein fractions and immunoglobulins in 46t cases of patients with various liver diseases who had been visited or admitted to he Department of Insternal Medicine, Busan National University Hospital and 20 cases of control subjects from May, 1979 to March, Jul 1980. The 46 cases of liver diseases were consisted of 13 cases of acute hepatitis. 13 cases of chronic hepatitis, 13 cases of liver cirrhosis and 7 cases of hepatocellular carcinoma, Diagnosis was confirmed clinically and histopathologically in all the patients. Serum protein fractions were measured by cellulose acetate electrophoresis and serum immunoglobulins were measured by radial single immunodiffusion method. The results obtained were summerized as follows : 1) In the acute hepatitis, the levels of alpha globulin, gamma-globulin, IgG and IgM were significantly increased than those of control. 2) In the chronic hepatitis, the levels of serum albumin was significantly decreased than that of control and acute hepatitis. The levels of gamma-globulin, IgG and IgM were significantly increased than those of the control. The level of IgA was significantly increased than that of the control and acute hapatitis. 3) In the liver cirrhosis, the level of albumin were significantly decreased than that of the control, acute hepatitis and chronic hepatitis. The level of gamma-globulin, IgG and IgM were significantly increased than those of the control. The level of IgA was significantly increased than that of the control and acute hepatitis. 4) In the hapatocellular carcinoma, the level of albumin was significantly decreased than that of the control and acute hepatitis. The level of alpha-globulin was significantly increased than that of the control, chronic hepatitis and liver cirrhosis. The levels of gamma-globulin and IgM significantly increased than those of the control and level of IgA was also significantly increased than that of the control and acute hepatitis.