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The Korean Journal of Pathology 1982;16(2): 165-172.
간질환에 있어서 혈청 단백분획들과 유산 탈수소 효소 Isoenzyme과의 관계
The Relation between Serum Proteins and Lactic Dehydrogenase Isoenzyme Activity in Liver Diseases
The author investigated the relation between serum protein fraction and lactic dehydrogenase (LD) isoenzyme activity in 28 cases of patients with various liver diseases who had visited or admitted to the Department of Internal Medicine, Busan National University Hospital and 34 cases of adult healthy control subjects from June, 1978 to July, 1979. The 28 cases of the liver disease were consisted of 8 cases of chronic hepatitis, 9 cases of liver cirrhosis and 11 cases of hepatocellular carcinoma. Total serum protein was measured by Biuret method and total serum LD activity was estimated by Caboud-Wr?blewski method. Serum protein fraction and LD isoenzyme activity were analyzed by cellulose acetate electrophoresis. The results obtained were summarized as follow 1) In the healthy control, there was no significant correlation between serum protein fractions and LD isoenzyme activities 2) In the chronic hepatitis, there was negative correlation between serum albumin and LD5 activity 3) In the liver cirrhosis, there was positive correlation between serum globulin and LD5 activity 4) In the hepatocellular carcinoma, there was negative correlation between LD5 activity and a1-, a2- and β-globulin, and also positive correlation between serum γ-globulin and LD4 & LD5 activity On the basis of above results, it was suggested that in differential diagnosis and evaluating clinical course and the effect of treatment of various liver diseases, evaluating the relation between serum protein fractions and LD isoenzyme activity might be more significant than that of each one of both separately.