Abstract

The concept of koilocytotic atypia of the cervix was defined and developed by Koss although the morphologic alterations were described previously by others. The koilocytotic atypia and squamous cell carcinoma frequently coexist and their histologic features sometimes merge imperceptibly. In the author's study, forty-five hysterectomized specimens were obtained for cervical squamous cell carcinoma to determined the association of the koilocytotic atypia with cervical malignancy. Forty-five controls were selected from patients who were underwent hysterectomy for uterine leiomyomas. According to a blind semiobjective scoring system of the Reid, the results are as follows: 1) The major histologic features of the neoplastic group were koilocytotic cytoplasmic vacuolization (98%), basal cell hyperplasia (98%), binucleation (96%) and dyskeratosis (93%). But stromal changes were not significant. Those of the control group were basal cell hyperplasia (31%), koilocytotic nuclear changes (13%) and acanthosis (13%). 2) Forty-three of 45 women (95.6%) showed histologic evidence of hyman papillomavirus infection. Forty-three of the controls, but none of the neoplastic group, had normal cervical epithelium. As a result, it was evident that there is association of koilocytotic atypia and cervical malignancy.