A case malignant lymphoma accompanied by lymph node infarction is presented and the literatures of the case are briefly reviewed. This 55-year-old female patient was admitted to the Department of Internal Medicine of the Presbyterian Medical Center Because of neck mass. The peripheral blood smears showed moderate anemia and leukopenia with a few immature cells. Bone marrow smears showed 70% cellularity with predominant atypical lymphocytes. Sectioned marrow tissue revealed also 70% cellularity with partial infiltration of lymphoma cells. Bilateral neck mass biopsy tissue revealed complete infarction of lymph nodes. So a case of lymph node infraction as a presenting sign of malignant lymphoma is reported.