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The Korean Journal of Pathology 1984;18(1): 32-38.
사람 송과체의 형태학적 관찰 -태아 및 출생후 송과체 80예 분석-
A Morphological Observation on Human Pineal Glands -80 cases analysis of fetal and postnatal pineals
To evaluate the histological appearance of the human pineals, a morphologic study was made based on 80 normal human pineals. The material consisted of 44 pineals from fetuses ranging in age from 16 to 40 gestational weeks and 36 pineals of children and adults ranging in age from 1 day to 58 years. Following observation were made: 1) The pineals show a distinctive pattern of evolution in the morphology through the entire life as judged by morphological features, such as glandular, alveolar, mosaic and locular pattern. 2) At 16 weeks of gestation are proliferated and become ependymal cells transformed into glial and primitive pineal parenchymal cells, that later become pinealoblasts by before 28 weeks of gestation. The pineals of newborn show the pattern of adult type by 10 months of age. 3) Melanin pigment deposits in the pineals is noted in 66 percent of the cases examined. The pigment is first seen in glandular structure at early gestational period and becomes visible in undifferented parenchymal cells or glial cells. Although pigment density varies intensity it is generally prominent through the gradually less prominent starting from 8 months of age and is minimal over the age 50 years.