A case of malignant mixed tumor of the main hepatic duct in a 49-year-old woman is reported and a review of the literature is made. The tumor was a polypoid mass, which occluded the common hepatic duct. Histologically the tumor was composed of various components representing, each adenocarcinoma, fibrosarcoma and osteogenic sarcoma. Interesting finding was diffusely scattered argyrophilic cells at adenocarcinoma area by Grimelius staining. This appears to be the first case of malignant mixed tumor of the extrahepatic bile duct.