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The Korean Journal of Pathology 1984;18(4): 463-470.
Kaposi 육종 1증례 보고
Kaposi's Sarcoma -A case report-
Kaposi's sarcoma is a slowly progressive and rare vascular tumor usually occurring on the lower extremities. It is characterized clinically by red-purple plaques and nodules. The essential histologic features of Kaposi's sarcoma include (1) proliferation of small vessels with endothelial cell; (2) proliferation of spindle shaped, somewhat pleomorphic cells having dark prominent nuclei; and (3) extravasation of erythrocytes and deposition of hemosiderin pigments. Also, infiltration of chronic inflammatory cells including lymphocytes, plasma cells, and large mononuclear cells is often present. 7 cases of Kaposi's sarcoma have been reported in Korea. Authors experienced a case of Kaposi's sarcoma in a 73 year old male who visited to the C.A.U. hospital complaining with multiple painless bluish papules and nodules on hands, legs, and feet for 3 years. The submitted specimen were two bluish brown excional biopsied skin, measuring 2×0.7×.0.5 cm and 1.5×0.6×0.6 cm. The epidermis of the larger one showed bluish nodular elevation with smooth surface. Cut surface showed bluish and hemorrhagic areas which were poorly delineated and located mainly in the dermis. Histologically, sections from plapue lesion of the right hand disclosed poorly demarcated and somewhat nodular areas of variable sized vascular proliferation associated with spindle cell proliferation. Hemosiderin pigments, extravasation of erythrocytes, and lymphocytic infiltration were also noted. Fewmitoses of spindle cells were seen, but vellular atypism and pleomorphism was rather mild. On reticulin staining, prominent vascular proliferation wasnoted in both papillary and reticular dermis. On Gomori trichrome staining, reddish endothelial cells were seen within the proliferated vascular channels. Also seen were fibroblast-like spindle cell proliferation at the stroma. Sections from bluish nodule of the right lower leg revealed moderate to marked hyperkeratosis, acanthosis, and dyskeratosis in the epidermis. Relatively nodular or parchy proliferation of vascular components associated perivascular spindle cell proliferation were noted at the whole layer of the epidermis, and even extended to subcutaneous adipose tissue. A few mitoses of spindle cells, extravasation of erythrocytes, and hemosiderin pigmentation were found along and near the proliferated vascular channels. Reticulin staining and Gomori trichrome staining revealed the similar histologic pattern as the above plaque lesion except more prominent nodular arrangement of vascular channels.
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