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The Korean Journal of Cytopathology 1996;7(2): 134-137.
Demonstration of TCM-9 Monoclonal Antibody in Follicular Neoplasm of Thyroid.
Yun Jung Kim, Jung Weon Shim, Hye Kyung Ahn, Young Euy Park
Department of Pathology, Hallym University, College of Medicine, Korea.
ABSTRACT
Monoclonal antibody(TCM-9) against human thyroid cancers have been studied by screening with human thyroid cancers, normal and benign thyroid tissue, and normal human serum protein. A monoclonal antibody(TCM-9) that is known to have strong specificity for human thyroid cancer but not for Graves' disease, adenoma or normal thyroid does not bind to native or mature human thyroglobulin(Tg). We used to TCM-9 antibody by immunohistochemical staining on 5 follicular cancer, 2 follicular adenoma, 1 follicular neoplasm with suspicious invasion, 2 papillary cancer to ascer- tain being of help in differentiation between follicular carcinoma and adenoma. Reactivity of TCM-9 was observed in follicular carcinoma and papillary carcinoma but not observed in follicular adenoma. Thus TCM-9 is a novel monoclonal antibody against the thyroid cancer.
Key Words: TCM-9; Papillary cancer; Follicular cancer; Follicular adenoma
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