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The Korean Journal of Pathology 1999;33(5): 385-368.
Signet Ring Cell Carcinoma of the Prostate A report of two cases.
Yu Na Kang, Sang Sook Lee, Tae Jin Lee, Jae Yoon Ro
1Department of Pathology, Keimyung University School of Medicine, Taegu 700-712, Korea.
2Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Korea.
ABSTRACT
Primary signet ring cell carcinoma of the prostate is extremely rare and about 18 cases have been reported in the literature. We report two cases of primary signet ring cell carcinoma of the prostate, arising in 79-year-old and 65-year-old men. Both cases were the poorly differentiated adenocarcinoma of the prostate with many signet ring cells. Signet ring cells were positive for prostatic specific antigen and prostatic acid phosphatase but negative for neutral and acid mucins. In summary, the signet ring cell carcinoma of the prostate is a rare variant of poorly differentiated adenocarcinoma of the prostate. The orgin of the prostate should be considered in cases of metastatic signet ring cell carcinoma, particularly when the signet ring cells are negative for neutral and acid mucins. Prostatic specific antigen and prostatic acid phosphatase should also be performed to confirm the primary signet ring cell carcinoma of the prostate.
Key Words: Prostate; Signet ring cell carcinoma; PSA; PAP