Warning: fopen(/home/virtual/jptm/journal/upload/ip_log/ip_log_2022-12.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 83 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 Journal of Pathology and Translational Medicine
Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine



Page Path
HOME > J Pathol Transl Med > Volume 35(3); 2001 > Article
Case Report Cellular Angiofibroma of the Vulva: A Report of Three Cases.
Hye Jeong Choi, Sung Nam Kim, Kyu Rae Kim
Journal of Pathology and Translational Medicine 2001;35(3):259-262
DOI: https://doi.org/
  • 16 Download
  • 0 Crossref
  • 0 Scopus
Department of Diagnostic Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Korea, Green Cross Reference Lab, Seoul, Korea, krkim@www.amc.seoul.kr

Cellular angiofibroma is a recently described, distinctive soft tissue tumor of the vulvovaginal region which is characterized by small, well-circumscribed tumors with fibroblastic differentiation. We report three cases of cellular angiofibroma of the vulva in middle-aged women. All three patients presented with painless swelling in the labium majora. The age of the three patients ranged from 43 to 56 years old (mean: 48 years old) and the size of the tumor ranged from 2 to 5 cm. The microscopic appearance was characterized by a cellular, well-circumscribed mass composed of uniform, bland, spindle stromal cells, numerous thick-walled, hyalinized vessels, and a scarce component of mature adipocytes. Immunohistochemical stains of the tumor cells show positivity for vimentin but negativity for smooth muscle actin, S-100 protein, desmin, factor VIII-related antigen and epithelial membrane antigen. The tumor should be differentiated from aggressive angiomyxoma and angiomyofibroblastoma because of its different clinicopathologic features, cells of origin and immunohistochemical findings.

Related articles

JPTM : Journal of Pathology and Translational Medicine