Department of Pathology, Yonsei University College of Medicine, Brain Korea 21 for Medical Sciences, Seoul 120-752, Korea. hkyonsei@yumc.yonsei.ac.kr
ABSTRACT
BACKGROUND: The molecular pathogenesis of gastric carcinoma is not yet well characterized. The purpose of this study is to assess the role of beta-catenin in gastric carcinogenesis.
METHODS: We analyzed beta-catenin expression using immunohistochemistry on 68 gastric adenomas and 34 gastric adenocarcinomas, and compared the result with pathological and molecular types of tumors and E-cadherin expression.
RESULTS: Nuclear expression of beta-catenin was noted more frequently in gastric adenomas than in carcinomas (40% vs.
21%, 0.05< or = P<1). There was no significant relationship between nuclear beta-catenin expression and histologic degree of adenoma, histologic type of carcinoma or microsatellite instability. E-cadherin expression showed significantly more frequent decrease in the membrane stainability of carcinomas compared to adenomas (P<0.01).
CONCLUSIONS: The frequent nuclear beta-catenin expression in gastric adenomas suggests that the beta-catenin alteration might play an early role in gastric carcinogenesis.
PDF Links
Full text via DOI 
Download Citation 
CrossRef TDM
E-Mail 
