Warning: fopen(/home/virtual/jptm/journal/upload/ip_log/ip_log_2023-02.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 83 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 Journal of Pathology and Translational Medicine
Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine



Page Path
HOME > J Pathol Transl Med > Volume 35(5); 2001 > Article
Original Article beta-Catenin Expression in Gastric Carcinogenesis.
Haeyoun Kang, Yon Rak Choi, Hoguen Kim
Journal of Pathology and Translational Medicine 2001;35(5):376-382
DOI: https://doi.org/
  • 10 Download
  • 0 Crossref
  • 0 Scopus
Department of Pathology, Yonsei University College of Medicine, Brain Korea 21 for Medical Sciences, Seoul 120-752, Korea. hkyonsei@yumc.yonsei.ac.kr

The molecular pathogenesis of gastric carcinoma is not yet well characterized. The purpose of this study is to assess the role of beta-catenin in gastric carcinogenesis.
We analyzed beta-catenin expression using immunohistochemistry on 68 gastric adenomas and 34 gastric adenocarcinomas, and compared the result with pathological and molecular types of tumors and E-cadherin expression.
Nuclear expression of beta-catenin was noted more frequently in gastric adenomas than in carcinomas (40% vs. 21%, 0.05< or = P<1). There was no significant relationship between nuclear beta-catenin expression and histologic degree of adenoma, histologic type of carcinoma or microsatellite instability. E-cadherin expression showed significantly more frequent decrease in the membrane stainability of carcinomas compared to adenomas (P<0.01).
The frequent nuclear beta-catenin expression in gastric adenomas suggests that the beta-catenin alteration might play an early role in gastric carcinogenesis.

Related articles

JPTM : Journal of Pathology and Translational Medicine