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The Korean Journal of Pathology 2002;36(1): 62-65.
Mixed Germ Cell-Sex Cord-Stromal Tumor of Non-Gonadoblastoma Type of Ovary: A Case Report.
Kwangseon Min, Byungha Choi, Kyu Rae Kim
Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Korea. krkim@www.amc.seoul.kr
We described a case of mixed germ cell-sex cord-stromal tumor of non-gonadoblastoma type (GCSCT-NG) of the ovary in a 2-year-old girl and compared its histological, immunohistochemical and ultrastructural findings with those of gonadoblastoma. The germ cell component showed an immunopositivity for cytokeratin and epithelial membrane antigen (EMA), and a negative reaction for -inhibin, alpha-fetoprotein (AFP), placental alkaline phosphatase (PLAP), vimentin and CD99. The sex cord elements showed an immunopositivity for cytokeratin, EMA, vimentin and inhibin, but negativity for AFP, PLAP, and CD99. The ultrastructural features showed desmosome-like cell junctions, suggesting spermatocytic differentiation from the primordial germ cells or gonocytes. Immunohistochemical and ultrastructural findings suggested that GCSCT-NG is probably a more differentiated form of mixed germ cell- sex cord-stromal tumor than gonadoblastoma.
Key Words: Ovarian Neoplasms-Sex Cord-Stromal Tumor