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HOME > J Pathol Transl Med > Volume 37(5); 2003 > Article
Case Report Silica Granuloma after Intermittent Intramuscular Injections: A Case Report.
Suk Jin Choi, Jong Im Lee, Jung Ran Kim, Tae Jung Jang, Ki Kwon Kim, Phil Hyun Chung
Journal of Pathology and Translational Medicine 2003;37(5):369-372
DOI: https://doi.org/
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1Department of Pathology, Dongguk University, College of Medicine, Kyongju, Korea. pathjrk@dumc.or.kr
2Department of Orthopaedic Surgery, Dongguk University, College of Medicine, Kyongju, Korea.

Most silica-contaminated wounds of the skin heal without complications. Cutaneous silica granuloma is a poorly understood, uncommon condition resembling a sarcoidosis. We report a case of silica granuloma after intermittent intramuscular injections. A 70-year-old man presented a painless mass in his right buttock for 2 weeks. He had received intermittent intramuscular injections of antihistamine drugs due to chronic dermatitis for 30 years. The histolopathological findings showed numerous hyalinized collagenous nodules with concentric layers, and an ill-defined chronic granulomatous inflammation containing foreign material. A polarized light microscopic examination revealed birefrigent particles. The presence of silica components was confirmed by scanning electron microscopy and energy dispersive X-ray microanalysis.

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