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The Korean Journal of Pathology 2003;37(6): 393-399.
Expression of p21, p53 and bcl-2 Proteins in Invasive Ductal Carcinoma of the Breast.
Hyang Jeong Jo, Ki Jung Yun, Hyung Bae Moon
1Department of Pathology, Gunsan Medical Center of Wonkwang University Hospital, Gunsan, Korea. hjc@kunmed.or.kr
2Department of Pathology, Wonkwang University School of Medicine, Iksan, Korea.
BACKGROUND: This study was designed to investigate the prognostic significance of p21, p53, and bcl-2 proteins in invasive ductal carcinoma of the breast. METHODS: Seventy-two cases of invasive ductal carcinoma were examined by immunohistochemical staining for p21, p53 and bcl-2 proteins. The results were correlated with clinicopathological variables, including age, tumor size, histologic grade, nuclear grade, lymph node status, estrogen receptor (ER) and progesterone receptor (PR) expression. RESULTS: Of 72 cases, p21, p53 and bcl-2 proteins were positive in 25 (34.8%), 35 (50.0%) and 27 (37.5%), respectively. There were no statistically significant correlations between the p21 protein expression and the other clinicopathological variables. The expression of p53 protein, however, showed a significant relation to ER expression, and that of bcl-2 was positively correlated with tumor size. In survival analysis, p21, p53, and bcl-2 proteins, nuclear grade and lymph node status were associated with survival rate. CONCLUSIONS: These results indicate that p21, p53, and bcl-2 proteins might play a role in tumorigenesis of breast carcinoma. In addition, the increased expression of p21, p53, and bcl-2 proteins could be used as factors suggesting poor prognosis in breast carcinomas.
Key Words: p21; p53; bcl; bcl-2; Breast Neoplasms