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The Korean Journal of Pathology 2004;38(5): 319-323.
Expression of Anaphase Promoting Complex (APC) and APC Regulatory Proteins in Invasive Ductal Carcinoma Associated with Paget's Disease.
Kwang Hwa Park, Sang Yeop Yi, Woo Ick Yang, Yup Kang, Kwang Gil Lee
1Department of Pathology, Wonju College of Medicine, Yonsei University, Wonju, Korea. lukebethel@hanmail.net
2Department of Pathology, Colledge of Medicine, Kwandong University, Goyang, Korea.
3Department of Pathology, College of Medicine, Yonsei University, Seoul, Korea.
4Institute for Medical Science, Ajou University, Suwon, Korea.
ABSTRACT
BACKGROUND: Oncogene expression in Paget's disease of the breast is not well known. To characterize invasive ductal carcinoma associated with Paget's disease, we studied expression of anaphase promoting complex (APC) with its regulatory proteins. METHODS: Immunohistochemical stainings were done with 10 cases of invasive ductal carcinoma associated with Paget's disease for APC, pituitary tumor transforming gene (PTTG), cyclin B1, p53, cyclin D1, and c-erbB-2. The expressions of these markers in Paget's disease were compared with those in the associated with carcinoma. RESULTS: APC, PTTG, cyclin B1, and c-erbB-2 were positive in all of the cases with both Paget's disease and underlying carcinoma. p53 was expressed in Paget's disease of 6 cases (60%) and in carcinoma of 7 cases (70%). Cyclin D1 was positive in Paget's disease of 8 cases (80%) and in carcinoma of 9 cases (90%). CONCLUSIONS: Breast carcinomas with Paget's disease seem to be distinguished by the high expression of APC, cyclin B1, PTTG, c-erbB2, and cyclin D1 in contrast to breast cancers without Paget's disease. Furthermore, the similar expression patterns of APC and APC regulatory proteins in both Paget's disease and underlying breast cancer support the epidermotropic theory as its pathogenetic mechanism.
Key Words: Paget's disease; Breast Cancer; Anaphase Promoting Complex; Cyclin B1- PTTG