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The Korean Journal of Pathology 2004;38(6): 430-433.
Isolated Intracranial Rosai-Dorfman Disease: A Case Report.
Jin Kyu Park, Mee Yon Cho, Kwang Hwa Park, Jhin Soo Pyen
1Departments of Pathology, Wonju Colledge of Medicine, Yonsei University, Wonju, Korea. abba@wonju.yonsei.ac.kr
2Departments of Neurosurgery, Wonju Colledge of Medicine, Yonsei University, Wonju, Korea.
ABSTRACT
Rosai-Dorfman disease (RDD) is an idiopathic histioproliferative disorder of the lymph nodes and extranodal sites. Central nervous system involvement is extremely rare. Intracranial RDD, especially the isolated form, resembles meninigioma both clinically and radiologically. Here, we report a case of isolated, intracranial, dura-based RDD. The patient presented with headache and dizziness with no evidence of lymphadenopathy. Histologically, the lesion consisted of large histiocytes with emperipolesis and lymphoplasma cell infiltrates with a fibrotic background. We discuss the differential diagnosis of this lesion. To our knowledge, this is the first reported Korean case of intracranial RDD.
Key Words: Rosai dorfman disease; Meninges; Intracranial
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