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The Korean Journal of Pathology 2005;39(5): 351-355.
Benign Histiocytoma of the Lung: A Case Report.
Myoung Ja Chung, Min Ho Kim, Hyun Jin Son
1Department of Pathology, Chonbuk National University Medical School, Jeonju, Korea. shjpathol@hotmail.com
2Department of Thoracic and Cardiovascular Surgery, Chonbuk National University Medical School, Jeonju, Korea.
3Research Institute for Medical Science, Jeonju, Korea.
Histiocytomas have rarely been reported in the lungs. We report an unusual benign pulmonary histiocytoma in a 45-year-old man and discuss the differential diagnosis. Chest CT showed a well-defined solitary pulmonary nodule of approximately 3 cm in size in the posterobasal segment of the right lower lobe. Posterolateral thoracotomy and wedge resection was performed. Gross examination revealed a mass, measuring 2.2 x 2.1 cm that had a circumscribed margin within the lung parenchyma. Microscopically, the tumor was entirely composed of large polygonal to round cells with a few chronic inflammatory cells. These tumor cells contained abundant cytoplasm which was either granular, eosinophilic or foamy. Immunohistochemically, these cells were diffusely positive for CD68 and focally positive for 1-antitrypsin, but negative for cytokeratin, vimentin, and smooth muscle actin.
Key Words: Histiocytoma; Lung