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HOME > J Pathol Transl Med > Volume 40(5); 2006 > Article
Case Report Pediatric Adrenal Cortical Neoplasm with Histologic Malignancy: A Case Report with Review of Literature.
So Hyung Park, Daeyeon Kim, Gyungyub Gong
Journal of Pathology and Translational Medicine 2006;40(5):370-372
DOI: https://doi.org/
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1Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. gygong@amc.seoul.kr
2Department of Pediatric Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Adrenal cortical neoplasm, especially carcinoma, is extremely rare in pediatric patients. We describe here a rare pediatric case of adrenal cortical neoplasm. A 2-year-old girl presented with an enlarged clitoris. The other physical findings and laboratory tests were nonspecific. The magnetic resonance imaging showed a 4 cm-sized heterogeneously enhancing soft tissue mass with calcification in the left adrenal gland. The mass was removed by laparoscopic operation. Grossly, several fragments of reddish tan soft tissue were present, and they weighed 19 gm in total. Microscopically, there were capsular invasion, diffuse/solid growth pattern with focal necrosis, high cellularity, cytoplasmic eosinophilia, marked nuclear pleomorphism, high N/C ratio, prominent nucleoli, atypical mitotic figures and calcifications, which all suggested adrenal cortical neoplasm of histologic malignancy. On immunohistochemistrical staining, there were positive reactivities to pancytokeratin, cytokeratin 7/20, CEA, inhibin and p53. The Ki-67 labeling index was about 6%. All these findings were indicative of adrenal cortical neoplasm of histologic malignancy.

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