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The Korean Journal of Pathology 2007;41(6): 427-429.
Pseudometastasis in Sentinel Lymph Nodes with Cytokeratin Debris-containing Histiocytes in Breast Cancer Patient: A Case Report.
Keum Ha Choi, Eun Jung Cha, Ha Na Choi, Woo Sung Moon
Department of Pathology, Institute for Medical Sciences, and the Center for Healthcare Technology Development, Chonbuk National University, Medical School, Jeonju, Korea. mws@chonbuk.ac.kr
ABSTRACT
Immunohistochemical staining for cytokeratins can detect false negative nodes in patients with breast carcinoma. We report on a patient with breast carcinoma and pseudometastasis detected by immunohistochemical staining within a negative sentinel lymph node. A 66-year-old woman underwent a simple mastectomy and sentinel lymph node biopsy. Immunohistochemical staining of the sentinel nodes for cytokeratin in permanent sections showed cells with intense cytoplasmic staining in the subcapsular sinus. The cells were negative for epithelial membrane antigen staining, but positive for CD68. In combination with morphologic findings and immunohistochemistry, cytokeratin-positive cells were confirmed as histiocytes with phagocytized cytokeratin debris. Careful correlation with histology and additional IHC could help avoid a misinterpretation of this type of pseudometastasis.
Key Words: Breast; Sentinel lymph node biopsy; Cytokeratin; Histiocytes; Pseudometastasis
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