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The Korean Journal of Pathology 2009;43(4): 351-354.
doi: https://doi.org/10.4132/KoreanJPathol.2009.43.4.351
Omental Histiocytic Sarcoma: A Case Report.
Sang Hak Han, Song Chul Kim, Min Hee Ryu, Chan Jeong Park, Joo Ryung Huh
1Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. jrhuh@amc.seoul.kr
2Department of General Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
3Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
4Department of Clinical Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
ABSTRACT
We report a case of perigastric histiocytic sarcoma (HS) involving the lesser omental sac in a 30-year-old man. HS is an exceedingly rare malignancy of mature tissue histiocyte. The tumor was a multi-lobulated, bulging enhancing mass in the lesser omentum with metastasis to lymph nodes and liver. The tumor consisted of diffuse non-cohesive proliferation of pleomorphic large oval to round neoplastic cells with giant cells showing vesicular chromatin and ample eosinophilic cytoplasm. In some areas, the tumor cells showed spindling with elongation of the nuclei and cellular shapes. Many of the tumor cells, especially giant forms contained phagocytosed lymphocytes. Immunohistochemical analysis of the tumor cells showed expression of leukocyte common antigen, CD68, lysozyme, vimentin, CD4, and CD163. Ki-67 index was 50-60%. After the operation, he was treated with chemotherapy, but the response was poor.
Key Words: Sarcoma; Histiocytic sarcoma; Omentum