| The Analysis and Clinical Usefulness of HPV DNA Chip Test in the Uterine Cervix. |
| Joo hyeon Jeong, Hyun Yee Cho, Na Rae Kim, Dong Hae Chung, Sanghui Park, Seung Yeon Ha |
1Department of Pathology, Graduate School of Medicine, Gachon University, Incheon, Korea.
2Department of Pathology, Gachon University Gil Hospital, Incheon, Korea. syha@gilhospital.com |
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| ABSTRACT |
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BACKGROUND: The genotypes of human papillomavirus (HPV) are important in carcinogenesis in uterine cervical cancer and may be different in geographic distribution.
METHODS: In 2,086 women, we analyzed the prevalence of HPV and HPV genotypes in uterine cervix by HPV-DNA chip test (n = 2,086), cytology (PAP smear, n = 1997) and biopsy (n = 546).
RESULTS: Of the 2,086 cases, 1,019 cases (48.8%) were HPV-positive and 1,067 cases (51.2%) were negative for HPV.
Single infection occurred most commonly (72.1% of women).
HPV genotypes in the high-risk and low-risk groups, respectively were HPV-16/-58/-18/-52/-53 and HPV-70/-6/-11.
The detection rates of HPV-70 in subjects older than 50 years increased significantly (p < 0.05). Infection in high risk subjects was detected in high grade lesions compared with infection in low risk subjects (p < 0.05).
CONCLUSIONS: HPV-16/-58/-18/-52/-53/-70/-6/-11 genotypes were common in the patient group similar to findings in East Asia. HPV-70 infection is predominant in those older than 40 years. |
| Key Words:
Human papillomavirus; Oligonucleotide array sequence analysis; Cytology; Cervix uteri |
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