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HOME > J Pathol Transl Med > Volume 44(1); 2010 > Article
Case Report Fine Needle Aspiration Cytology of Langerhans Cell Histiocytosis of Mandible: A Case Report.
Sang Ryung Lee, Jae Hee Suh, Hee Jung Cha, Young Min Kim, Hye Jeong Choi
Journal of Pathology and Translational Medicine 2010;44(1):106-109
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.1.106
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1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
2Department of Pathology, Ulsan University Hospital, Ulsan, Korea. thanksg@uuh.ulsan.kr

We present a case of mandibular involvement with Langerhans cell histiocytosis (LCH), diagnosed by ultrasound-guided aspiration and subsequently confirmed by incisional biopsy and immunohistochemistry in an eight-year-old boy. The cytologic findings included the presence of characteristic Langerhans cells of both mononucleate and multinucleate form. Diagnostic confirmation was obtained by immunopositivity for S-100 protein and CD1a of Langerhans histiocytes on paraffin-embedded sections obtained during incisional biopsy of the right mandibular area. By reporting a case of childhood LCH, we correlate the cytologic findings with histologic features and discuss the role of aspiration cytologic diagnosis in such a rare and cytomorphologically characteristic case.

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