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The Korean Journal of Pathology 2010;44(1): 106-109.
doi: https://doi.org/10.4132/KoreanJPathol.2010.44.1.106
Fine Needle Aspiration Cytology of Langerhans Cell Histiocytosis of Mandible: A Case Report.
Sang Ryung Lee, Jae Hee Suh, Hee Jung Cha, Young Min Kim, Hye Jeong Choi
1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
2Department of Pathology, Ulsan University Hospital, Ulsan, Korea. thanksg@uuh.ulsan.kr
We present a case of mandibular involvement with Langerhans cell histiocytosis (LCH), diagnosed by ultrasound-guided aspiration and subsequently confirmed by incisional biopsy and immunohistochemistry in an eight-year-old boy. The cytologic findings included the presence of characteristic Langerhans cells of both mononucleate and multinucleate form. Diagnostic confirmation was obtained by immunopositivity for S-100 protein and CD1a of Langerhans histiocytes on paraffin-embedded sections obtained during incisional biopsy of the right mandibular area. By reporting a case of childhood LCH, we correlate the cytologic findings with histologic features and discuss the role of aspiration cytologic diagnosis in such a rare and cytomorphologically characteristic case.
Key Words: Histiocytosis; Langerhans cell; Mandible; Cytology; Child