Warning: fopen(/home/virtual/jptm/journal/upload/ip_log/ip_log_2022-12.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 83 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 Journal of Pathology and Translational Medicine
Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine



Page Path
HOME > J Pathol Transl Med > Volume 44(5); 2010 > Article
Original Article Significance of Osteopontin Expression in the Progression of Human Focal Segmental Glomerulosclerosis.
Ghil Suk Yoon, Tae Sook Kim
Journal of Pathology and Translational Medicine 2010;44(5):462-468
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.462
  • 17 Download
  • 1 Crossref
  • 1 Scopus
1Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.
2Department of Pathology, Inha University School of Medicine, Incheon, Korea. tskim@inha.ac.kr

Osteopontin (OPN) is a cytokine related to cell-matrix adhesion and cell survival and is expressed in the distal convoluted tubules in normal adult kidneys. Only one in vitro study has investigated the role of OPN in mechanically stretched podocytes and their actin cytoskeleton rearrangement.
Glomerular OPN expression was investigated in biopsies from patients with human idiopathic focal segmental glomerulosclerosis (FSGS) (n = 25) and in normal renal biopsies (n = 16) by immunohistochemistry.
OPN was expressed in the podocytes from patients with FSGS. OPN expression increased in podocytes from both non-sclerotic hypertrophic and sclerotic glomerular tufts in patients with FSGS compared to the podocytes in normal controls.
The results suggest that OPN plays a role in the early adaptive response of podocytes to the increased mechanical load caused by glomerular hypertrophy preceding FSGS. OPN was involved in cell-matrix adhesion and influenced the detachment delay of podocytes from the glomerular basement membrane and apoptosis.

Related articles

JPTM : Journal of Pathology and Translational Medicine