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Application of Bethesda System for Reporting Thyroid Aspiration Cytology.
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HOME > J Pathol Transl Med > Volume 44(5); 2010 > Article
Original Article Application of Bethesda System for Reporting Thyroid Aspiration Cytology.
Kyungji Lee, Chan Kwon Jung, Kyo Young Lee, Ja Seong Bae, Dong Jun Lim, So Lyung Jung
Journal of Pathology and Translational Medicine 2010;44(5):521-527
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.521
1Department of Hospital Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea. ckjung@catholic.ac.kr
2Department of Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea.
3Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
4Department of Radiology, The Catholic University of Korea College of Medicine, Seoul, Korea.
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Abstract

BACKGROUND
The Bethesda classification system for reporting on thyroid fine-needle aspiration (FNA) cytology was recently proposed by the National Cancer Institute, USA. We aimed to report our experience with applying this system for thyroid FNA, with a focus on comparing it with the four categorical system.
METHODS
We retrospectively reviewed the 4,966 thyroid FNAs that were performed at the Seoul St. Mary's Hospital between October 2008 and September 2009. All the FNAs were classified according to the Bethesda system and the four tier system.
RESULTS
The cytologic diagnoses of the Bethesda system included 10.0% unsatisfactory, 67.7% benign, 3.1% atypia of undetermined significance, 0.6% follicular neoplasm, 0.5% follicular neoplasm, Hurthle cell type, 5.1% suspicious for malignancy and 13.0% malignancy. Using four tier system, 10.1%, 67.6%, 9.3%, and 13% were diagnosed as unsatisfactory, negative for malignancy, atypical cells and malignancy, respectively. Of the 4,966 nodules, 905 were histologically confirmed. The specificity of the Bethesda system and the four tier system for diagnosing malignancy was 99.6% and 82.6%, respectively.
CONCLUSIONS
The Bethesda system can classify indeterminate thyroid nodules into more detailed categories and provide clinicians with useful information for management.

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© The Korean Society of Pathologists and the Korean Society for Cytopathology.
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