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HOME > J Pathol Transl Med > Volume 45(5); 2011 > Article
Original Article Expression of Hepatocyte Growth Factor/c-met by RT-PCR in Meningiomas.
Na Rae Kim, Yang Seok Chae, Weon Jeong Lim, Seong Jin Cho
Journal of Pathology and Translational Medicine 2011;45(5):463-468
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.5.463
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1Department of Pathology, Gachon University Gil Hospital, Incheon, Korea.
2Department of Pathology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
3Department of Neurochiatry, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea.
4Department of Pathology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. embrael21@empal.com

BACKGROUND
Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the c-met oncogene. The HGF/c-met signaling pathway may play various roles in the carcinogenesis of various organs.
METHODS
We examined HGF and c-met mRNA expression by utilizing reverse transcription polymerase chain reaction on 40 surgically resected intracranial meningiomas (25 benign, 10 atypical, and 5 anaplastic cases).
RESULTS
An HGF overexpression was detected in 28%, 50%, and 80% of the benign, atypical and anaplastic meningiomas, respectively; a high expression of HGF or the coexpression of HGF/c-met was detected in the high grade meningiomas (the atypical and anaplastic cases, p=0.046, p=0.014). An HGF expression was statistically significant in the recurrent meningiomas (p=0.003), and HGF expression was significantly lower than c-met mRNA expression in benign meningiomas (p=0.034).
CONCLUSIONS
There was no correlation between histologic subtypes and HGF/c-met expression. Determination of HGF expression can be used as a molecular predictor for recurrence of meningioimas. These results suggest that HGF and c-met expression in meningiomas may be associated with anaplastic progression.

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