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The Korean Journal of Pathology 2011;45(6): 573-581.
doi: https://doi.org/10.4132/KoreanJPathol.2011.45.6.573
Prognostic Implication of Programmed Death-1-Positive Tumor-infiltrating Lymphocytes in Diffuse Large B-Cell Lymphoma.
Young Sin Ko, Young Ha Oh, Chan Kum Park, Wook Youn Kim, Hye Seung Han, So Dug Lim, Tae Sook Hwang, Wan Seop Kim
1Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. wskim@kuh.ac.kr
2Department of Pathology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
3Department of Pathology, Hanyang University College of Medicine, Seoul, Korea.
4Department of Pathology, The Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea.
BACKGROUND: Programmed death-1 (PD-1) is physiologically expressed by germinal center-associated helper T-cells and has an inhibitory effect on T-cell activity. METHODS: We examined 63 cases of diffuse large B-cell lymphoma (DLBCL) and determined the number of PD-1-positive helper T-cells in a representative tumor area after immunohistochemical staining using a monoclonal antibody against PD-1. The PD-1-positive cells were counted in 3 high-power fields (HPFs; 400x). RESULTS: Patients were divided into 2 groups: one with a high number of PD-1-positive cells (>20/HPF, n=33) and one with a low number of PD-1-positive cells (< or =20/HPF, n=30). The former group showed decreased overall survival, but at a statistically non-significant level (p=0.073). A high number of PD-1-positive cells was more common in patients at an advanced clinical stage and with high international prognostic index score (p=0.025 and p=0.026, respectively). The number of extranodal sites also somewhat correlated with the PD-1 staining status (p=0.071). However, the number of PD-1-positive cells was not associated with patient age, serum lactate dehydrogenase level, and Eastern Cooperative Oncology Group performance score. CONCLUSIONS: The high number of PD-1-positive cells might be associated with an unfavorable outcome in DLBCL patients.
Key Words: Lymphoma, large B-cell, diffuse; Programmed death-1 (PD-1); Lymphoma; Prognostic factor