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HOME > J Pathol Transl Med > Volume 45(6); 2011 > Article
Case Report Systemic Plasmacytosis: A Case Report with a Review of the Literature.
Sung Hak Lee, Chang Young Yoo, Ji Han Jung, Jin Young Yoo, Suk Jin Kang, Chang Suk Kang
Journal of Pathology and Translational Medicine 2011;45(6):632-638
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.6.632
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Department of Hospital Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea. jinyyoo@catholic.ac.kr

Systemic plasmacytosis is an uncommon disorder characterized by widely disseminated macular skin eruptions composed of polyclonal lymphoplasmacytic infiltrates associated with variable extracutaneous involvement. An aggressive clinical course has been observed in a small number of patients, but most cases have followed chronic and benign clinical course without spontaneous remission. Previously reported cases of this entity have been described almost exclusively in Japanese patients. We recently experienced a case of systemic plasmacytosis in a 48-year-old Korean female patient. Initial skin biopsy specimen revealed patchy perivascular and periadnexal infiltrates of mature plasma cells. Serum immunoelectrophoresis revealed polyclonal hypergammaglobulinemia, and polyclonal plasmacytosis was noted on the subsequent biopsy specimens of left supraclavicular and axillary lymph nodes. Multiple tiny pulmonary nodules appeared six years after the initial cutaneous presentation and were found to be of the same histologic appearance. We herein report a rare case of systemic plasmacytosis with a review of the literature.


JPTM : Journal of Pathology and Translational Medicine