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The Korean Journal of Cytopathology 2001;12(2): 131-134.
Cytologic diagnosis of a chordoma without physaliferous cells: A case report.
Yun Hee Jin, Chan Kum Park, Won Mi Lee, Moon Hyang Park
Department of Pathology, College of Medicine, Hanyang University, Seoul, Korea. parkcg@hanyang.ac.kr
Cytologic features of conventional chordoma have been described and most reports emphasize the presence of large cells with numerous well defined cytoplasmic vacuoles or physaliferous cells. We report fine needle aspiration cytologic (FNAC) findings of a case of chordoma without physaliferous cells. The smear was cellular and composed of large cohesive clusters or individually scattered cells in mucinous background. The round or cuboidal cells had centrally located nuclei with fine granular chromatin, inconspicuous nucleoli, and occasional vacuolated cytoplasm. Mild to moderate pleomorphism was noted. Physaliferous cells are extremely helpful when present in cytologic material, but they are not necessary for diagnosis. Thus clinical history, roentgenographic appearance, and exact location of the lesion are required for the successful interpretation of presacral aspirates together with cytologic findings.
Key Words: Chordoma; Physaliferous cells; Fine needle aspiration cytology