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The Korean Journal of Cytopathology 2007;18(2): 161-164.
Metastatic Melanoma Mimicking a Papillary Carcinoma of the Thyroid in Fine Needle Aspiration Cytology: A Case Report.
Young Ok Hong, Jae Hee Suh, Hee Jeong Cha, Hye Jeong Choi, Young Min Kim
1Department of Pathology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea. ymkpath@uuh.ulsan.kr
2Department of Pathology, Asan Medical Center, Seoul, Korea.
Metastasis to the thyroid gland is very rare in clinical practice. We recently encountered a 65-year-old woman who presented with a large thyroid nodule that mimicked the cytologic features of a papillary thyroid carcinoma on fine needle aspiration biopsy (FNAB). Although initially diagnosed as a papillary thyroid carcinoma, a thorough clinical work-up revealed multiple lesions in the bones, liver, and nasal cavity, which were confirmed as metastases of a malignant melanoma. Despite a thorough physical examination, however, the primary skin lesion could not be identified. Although FNAB shows a high degree of accuracy in diagnosing primary thyroid tumors, it is less accurate in diagnosing metastases to the thyroid gland. A thorough clinical history with appropriate immunohistochemical staining assays is necessary for the accurate diagnosis of metastatic malignant melanoma.
Key Words: Malignant melanoma; Thyroid gland; Metastasis