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The Korean Journal of Cytopathology 2007;18(2): 170-174.
Imprint Cytology of Granular Cell Tumor: A Case Report.
Woo Jung Sung, Joon Hyuk Choi
Department of Pathology Yeungnam University College of Medicine, Daegu, Korea. joonhyukchoi@yumail.ac.kr
Granular cell tumor is a rare tumor of the soft tissue and this is characterized by proliferation of large cells with granular appearing eosinophilic cytoplasm. We report the imprint cytologic features of a case of granular cell tumor in the left calf of a 52-year-old woman. Microscopic examination showed moderate cellularity. The tumor cells were arranged both as single cells and in clusters. The cells were large polygonal-shaped and they had small round nuclei with finely granular chromatin and occasionally conspicuous nucleoli. The cytoplasm was abundant eosinophilic and granular. Naked nuclei and spindle-shaped tumor cells were occasionally noted. No mitosis and necrosis were present. The background showed cytoplasmic granular materials. The tumor cells showed positivity for S-100 protein. Ultrastructurally, abundant lysosomes were present in the cytoplasm of the tumor cells.
Key Words: Granular cell tumor; Soft tissue; Cytology; Imprint