Warning: fopen(/home/virtual/jptm/journal/upload/ip_log/ip_log_2023-04.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 83 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 Journal of Pathology and Translational Medicine
Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine



Page Path
HOME > J Pathol Transl Med > Volume 22(1); 1988 > Article
Original Article An Immunohistochemical Study of Alpha-1-antichymotrypsin and Lysozyme in the Hofbauer Cells of Human Placentas.
Ho Won Hwang, Ho Jong Chun, Chae Hong Suh
Journal of Pathology and Translational Medicine 1988;22(1):63-69
DOI: https://doi.org/
  • 10 Download
  • 0 Crossref
  • 0 Scopus
1Department of Pathology, Asan Foundation attached Jung Eub General hospital, Jungeub, Korea.
2Department of Pathology, College of Medicine, Chosun University, Korea.

The present study has shown that immunohistochemical staining of the human placentas (5 first trimester and 20 full term placentas) for confirmation of the monocytic linease of its macrophage function. We used two macrophage associated glycoprotein; alpha-1-antichymotrypsin (A1Ac) and lysozyme (LSZ). The results from presence or absence of A1Ac & LSZ by immunohistochemical methods can be helpful to deceide the degree of differentiation of macrophage. In al the placentas examined a strong cytoplasmic reaction for A1Ac was seen in the Hofbauer cells, and the same cells of serial sections didn't stain for LSZ. The strong cytoplasmic reaction for A1Ac supports that Hofbauer cells are macrophage, but they didn't stain for LSZ, a bactericidal enzyme, we propose that these cells are not fully differentiated macrophage. The lack of LSZ may have some relevance to the pathogenesis of certain placental infections.

Related articles

JPTM : Journal of Pathology and Translational Medicine