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HOME > J Pathol Transl Med > Volume 22(2); 1988 > Article
Case Report Porencephaly: An Autopsy Case Report.
In Sook Kim, Jin Hee Shon, Hyo Sook Park, Je Geun Chi
Journal of Pathology and Translational Medicine 1988;22(2):199-203
DOI: https://doi.org/
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1Department of Pathology, National Medical Center, Seoul, Korea.
2Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea.

Porencephaly is a rare congenital anomaly characterized by a cavitary hole extending from the cerebral mantle to the ventricle of the brain and covered by leptomeningeal membrane. It is now generally believed that the porencephaly represents a fetal or neonatal destructive process of the neural tissue. Authors experienced an autopsy case of bilateral porencephaly in a 35-day-old Korean male infant who died of sepsis. The brain weighed 150 gms and morphologically well formed except for two large symmetric defects at the fronto-parietal region. These defects were characterized by cleft-like shape, covering the entire cerebral mantle with resultant direct communication between ventricular cavity and leptomeninges. Thin leptomeningeal trabeculae were covering the cavity. There was a smooth transition between ependyma and roof of the defects. There are focal, microscopic cerebral infarct and abscess without connection with the cavitary lesion. The remaining central nervous system was unremarkable.

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