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HOME > J Pathol Transl Med > Volume 25(3); 1991 > Article
Case Report Hepatic Candidiasis: A case occurred in a patient with leukemia.
Chan Il Park, Sun Hee Sung, Eun Kyung Han, Ho Guen Kim
Journal of Pathology and Translational Medicine 1991;25(3):275-277
DOI: https://doi.org/
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Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

In view of the possible role of portal circulation in hematogenous spread of Candida species, a case of hepatic candidiasis occurred in an eight-year-old child with acute lymphoblastic leukemia (ALL) treated by chemotherapy is presented. Symptoms and signs referable to the hepatic disease in this patient included hepatomegaly, icteric sclera and abdominal pain. There were no particular manifestations suggestive of deep mycotic involvement of any sepcific organs or tissues other than the liver. Culture of the blood was negative for one month. On the 24th hospital day the patient died with the presumptive diagnosis of ALL, disseminated intravascular coagulation, acute renal failure, pulmonary edema, cholecystitis and oral thrush. A needle necropsy was performed and revealed fungal aggregates replacing the large foci of hepatic cell loss. It is suggested that, when the gastrointestinal tract serves as the portal of entry, the liver could be the visceral organ involved first in the course of disseminated candidiasis.

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