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HOME > J Pathol Transl Med > Volume 26(1); 1992 > Article
Original Article Light Electron Microscopic Study in Rat Livers Following Cadmium Chloride Administration.
Kwan Kyu Park, Young Ho Kim, Kun Young Kwon, Eun Sook Chang, Moo Ung Chang
Journal of Pathology and Translational Medicine 1992;26(1):28-39
DOI: https://doi.org/
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1Department of Pathology, Keimyung University School of Medicine, Taegu, Korea.
2Department of Biology, Yeungnam University, Korea.

This study was carried out to investigate the light and electron microscopic findings of the livers of rats after an intraperitoneal injection of cadmium chloride. The Sprague-Dawley rats were intraperitoneally injected with cadmium chloride dissolved in water, once a day for three days. These animals were sacrificed at 1, 3, 8, and 24 hr after the last injection. Control groups of the rats were also sacrificed in the same manner. The liver was extirpated and examined by both light and electron microscopy. The results obtained are as follows: The parenchyma of the liver shows focal neutrophilic infiltration and spotty necrosis. The hepatocytes show fatty change, ballooning degeneration, swelling of the endoplasmic reticulum and mitochondria, increase numbers of secondary lysosomes and residual bodies. Focal patic venules and sinusoids of the liver are congested. The Kupffer cells are increase in number. Therefore, it can be concluded that the cadmium is directly acted to hepatocytes resulting in cellular injuries and deposits in the fat droplets of the cytoplasm of the hepatocytes, not Ito cells as previously suggeted.

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