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The Korean Journal of Pathology 1992;26(1): 76-81.
Epithelial-Myoepithelial Carcinoma of Intercalated Duct of Parotid Gland.
Soong Deok Lee, Doo Hyun Chung, Sung Hye Park, Chul Woo Kim, Je G Chi
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Epithelial-myoepithelial carcinoma of intercalated duct(origin) is a recently described tumor characterized by its typical biphasic pattern of central duct like cell and peripheral clear cell. We described a case of epithelial-myoepithelial carcinoma in a 10-year-old boy. Microscopically, the tumor showed typical biphasic pattern, diffuse proliferation of clear cells and linining epithelial cells of tubular structures. Immunohistochemically, the clear cell showed positive reaction to S-100 protein, and the epithelial cells expressed cytokeratin indicating myoepithelial and epithelial differentiation respectively. Biphasic differentiation of the tumor cells could be also proved by electronmicroscopic study.
Key Words: Epithelial-myoepithelial carcinoma of intercalated duct(origin); Salivary gland; Parotid; Myoepithelial cells; Immunohistochemistry