Journal of Pathology and Translational Medicine

Jong Hee Nam

17 Articles

WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study.: Jin Man Kim, Young Hyeh Ko, Seung Sook Lee, Jooryung Huh, Chang Suk Kang, Chul Woo Kim, Yun Kyung Kang, Jai Hyang Go, Min Kyung Kim, Wan Seop Kim, Yoon Jung Kim, Hyun Jung Kim, Hee Kyung Kim, Jong Hee Nam, Hyung Bae Moon, Chan Kum Park, Tae In Park, Young Ha Oh, Dong Wha Lee, Jong Sil Lee, Juhie Lee, Hyekyung Lee, Sung Chul Lim, Kyu Yun Jang, Hee Kyung Chang, Yoon Kyung Jeon, Hye Ra Jung, Min Sun Cho, Hee Jeong Cha, Suk Jin Choi, Jae Ho Han, Sook Hee Hong, Insun Kim; Korean J Pathol. 2011;45(3):254-260.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.3.254

7,007 View
138 Download
68 Crossref

BACKGROUND
The aim of study was to determine the relative frequency of malignant lymphoma according to World Health Organization (WHO) classification in Korea.
METHODS
A total of 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site of involvement and immunophenotypes were obtained.
RESULTS
The relative frequency of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) was 95.4% and 4.6%, respectively. B-cell lymphomas accounted for 77.6% of all NHL, while T/natural killer (T/NK)-cell lymphomas accounted for 22.4%. The most frequent subtypes of NHL were diffuse large B-cell lymphoma (42.7%), extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (19.0%), NK/T-cell lymphoma (6.3%) and peripheral T-cell lymphoma (PTCL), unspecified (6.3%), in decreasing order. The relative frequency of HL was nodular sclerosis (47.4%), mixed cellularity (30.6%), and nodular lymphocyte predominant (12.1%) subtypes. Compared with a previous study in 1998, increase in gastric MZBCL and nodular sclerosis HL, and slight decrease of follicular lymphoma, PTCL, and NK/T-cell lymphoma were observed.
CONCLUSIONS
Korea had lower rates of HL and follicular lymphoma, and higher rates of extranodal NHL, extranodal MZBCL, and NK/T-cell lymphoma of nasal type compared with Western countries. Changes in the relative frequency of lymphoma subtypes are likely ascribed to refined diagnostic criteria and a change in national health care policy.

Citations

Citations to this article as recorded by

Pattern of Bone Marrow Involvement in B-cell Non-Hodgkin’s Lymphoma - Experience from a Tertiary Care Center in North India
Shareefa Akhter, Nusrat Bashir, Mohmad Hussain Mir, Fahim Manzoor, Maniza Ayub, Malik Tariq Rasool, Sheikh Bilal
Journal of Radiation and Cancer Research.2024; 15(2): 64. CrossRef
Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma
Esther Wei Yin Chang, Ya Hwee Tan, Jason Yongsheng Chan
Journal of Hematology & Oncology.2024;[Epub] CrossRef
Primary extranodal lymphomas: Five-year experience from a tertiary care center of North India
Priyanka Mishra, Manoj Prashar, Nidhin Rehman, Anamika Sinha, Deep K. Raman
Indian Journal of Cancer.2024; 61(1): 16. CrossRef
Characteristics of Gastric Mucosa-associated Lymphoid Tissue Lymphoma in Korea
Tae-Woo Kim, Joon Sung Kim
The Korean Journal of Gastroenterology.2024; 84(6): 243. CrossRef
Identification and overcoming rituximab resistance in diffuse large B-cell lymphoma using next-generation sequencing
Min Ji Jeon, Eun Sang Yu, Chul Won Choi, Dae Sik Kim
The Korean Journal of Internal Medicine.2023; 38(6): 893. CrossRef
Estimating the global burden of Epstein–Barr virus-related cancers
Yide Wong, Michael T. Meehan, Scott R. Burrows, Denise L. Doolan, John J. Miles
Journal of Cancer Research and Clinical Oncology.2022; 148(1): 31. CrossRef
Epidemiological Characteristics of Peripheral T-Cell Lymphoma: A Population-Based Study
Shuo Liu, Weiping Liu, Huichao Li, Lei Yang, Yuqin Song, Xi Zhang, Yangyang Cheng, Qingyu Li, Haoxin Li, Ning Wang, Jun Zhu, Jiafu Ji
Frontiers in Oncology.2022;[Epub] CrossRef
Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer
Xinjie Lu
Current Medicinal Chemistry.2022; 29(41): 6228. CrossRef
Clinical course of duodenal mucosa‐associated lymphoid tissue lymphoma: Comparison with gastric mucosa‐associated lymphoid tissue lymphoma
Hee Kyong Na, Sung Hyun Won, Ji Yong Ahn, Ga Hee Kim, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon‐Yong Jung, Hwa Jung Kim
Journal of Gastroenterology and Hepatology.2021; 36(2): 406. CrossRef
Real-world data on the survival outcome of patients with newly diagnosed Waldenström macroglobulinemia
Jang Ho Cho, Joon-Ho Shim, Sang Eun Yoon, Hee-Jin Kim, Sun-Hee Kim, Young Hyeh Ko, Seung-Tae Lee, Kihyun Kim, Won Seog Kim, Seok Jin Kim
The Korean Journal of Internal Medicine.2021; 36(3): 668. CrossRef
Primary Gastrointestinal T/NK Cell Lymphoma
Eun Kyung Kim, Mi Jang, Woo Ick Yang, Sun Och Yoon
Cancers.2021; 13(11): 2679. CrossRef
Mucosa-Associated Lymphoid Tissue Lymphoma of the Cheek Mimicking Benign Entities: a Case Report
Hyun Hwang, Jae Ho Shin, Yon Kwon Ihn, Sungjun Han, Hong Sik Park
Investigative Magnetic Resonance Imaging.2021; 25(2): 129. CrossRef
Classification of non-Hodgkin lymphoma in the Middle Euphrates Region of Iraq according to the World Health Organization classification
Ahmed Mjali, AlyaaHadi Oudah, HaiderHasan Jaleel Al-Shammari, NareenTawfeeq Abbas
Iraqi Journal of Hematology.2021; 10(2): 170. CrossRef
Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting
Jeffrey I. Cohen, Keiji Iwatsuki, Young-Hyeh Ko, Hiroshi Kimura, Irini Manoli, Koichi Ohshima, Stefania Pittaluga, Leticia Quintanilla-Martinez, Elaine S. Jaffe
Leukemia & Lymphoma.2020; 61(4): 808. CrossRef
Cutaneous lymphoma in Japan, 2012–2017: A nationwide study
Kazuyasu Fujii, Toshihisa Hamada, Takatoshi Shimauchi, Jun Asai, Yasuhiro Fujisawa, Hironobu Ihn, Norito Katoh
Journal of Dermatological Science.2020; 97(3): 187. CrossRef
Practical Approach to the Histologic Diagnosis of Gastrointestinal Lymphomas Through the First-line Marker Battery of CD20, CD3, CD30, and Epstein-Barr Virus–encoded RNAs
Eun Kyung Kim, Woo Ick Yang, Hyang Joo Ryu, Hee Lee Ji, Sun Och Yoon
Advances in Anatomic Pathology.2020; 27(2): 75. CrossRef
Treatment of mantle cell lymphoma in Asia: a consensus paper from the Asian Lymphoma Study Group
Dok Hyun Yoon, Junning Cao, Tsai-Yun Chen, Koji Izutsu, Seok Jin Kim, Yok Lam Kwong, Tong Yu Lin, Lim Soon Thye, Bing Xu, Deok Hwan Yang, Won Seog Kim
Journal of Hematology & Oncology.2020;[Epub] CrossRef
Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman disease
Jiwon Koh, Yoon Kyung Jeon
Journal of Pathology and Translational Medicine.2020; 54(3): 253. CrossRef
Discovery of Novel Recurrent Mutations and Clinically Meaningful Subgroups in Nodal Marginal Zone Lymphoma
Jiwon Koh, Insoon Jang, Seongmin Choi, Sehui Kim, Ingeon Jang, Hyun Kyung Ahn, Cheol Lee, Jin Ho Paik, Chul Woo Kim, Megan S. Lim, Kwangsoo Kim, Yoon Kyung Jeon
Cancers.2020; 12(6): 1669. CrossRef
Clinicopathological and Immunophenotype Spectrum of Malignant Lymphoma in Eastern India Population – A Tertiary Care Hospital Study
Debahuti Mohapatra, Rajashree Tripathy, Prateek Das, Pallak Batalia
Journal of Evidence Based Medicine and Healthcare.2020; 7(38): 2120. CrossRef
Cost-utility analysis of pralatrexate for relapsed or refractory peripheral T-cell lymphoma based on a case-matched historical control study along with single arm clinical trial
Seonyoung Park, Ah-Young Kim, Hyeonseok Cho, Deborah Baik, Hankil Lee, Sunghwa Cho, Hye-Young Kang
BMC Cancer.2020;[Epub] CrossRef
Extranodal non-Hodgkin’s lymphoma: A case series at a tertiary care hospital
Pomilla Singh, Ravi Swami, Shashank Singh, N S Mani, M N Karandikar
IP Archives of Cytology and Histopathology Research.2020; 5(4): 302. CrossRef
Pediatric non‐Hodgkin lymphoma: Characteristics, stratification, and treatment at a single institute in Thailand
Worawut Choeyprasert, Usanarat Anurathapan, Samart Pakakasama, Nongnuch Sirachainan, Duantida Songdej, Surapong Lertthammakiat, Suradej Hongeng
Pediatrics International.2019; 61(1): 49. CrossRef
Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases
Wook Youn Kim, Ivonne A. Montes-Mojarro, Falko Fend, Leticia Quintanilla-Martinez
Frontiers in Pediatrics.2019;[Epub] CrossRef
Chimeric Antigen Receptor T-Cell Therapy for Diffuse Large B-Cell Lymphoma
Heejung Chae, Dok Hyun Yoon
The Korean Journal of Medicine.2019; 94(2): 152. CrossRef
Classification of malignant lymphoma subtypes in Korean patients: a report of the 4th nationwide study
Hye-Ra Jung, Jooryung Huh, Young-Hyeh Ko, Yoon Kyung Jeon, Sun Och Yoon, Se Hoon Kim, Woo Ick Yang, Geongsin Park, Jo Heon Kim, Jin Ho Paik, Jae Ho Han, Hee Jung Cha, Kyu Yun Jang, Bong-Kyung Shin, Young-A Kim, Ji Eun Kim, Yoo Duk Choi, Min Gyoung Park, H
Journal of Hematopathology.2019; 12(4): 173. CrossRef
Phase II study of R–CVP followed by rituximab maintenance therapy for patients with advanced marginal zone lymphoma: consortium for improving survival of lymphoma (CISL) study
Sung Yong Oh, Won Seog Kim, Jin Seok Kim, Seok Jin Kim, Dok Hyun Yoon, Deok‐Hwan Yang, Won Sik Lee, Hyo Jung Kim, Ho‐Young Yhim, Seong Hyun Jeong, Jong Ho Won, Suee Lee, Jee Hyun Kong, Sung‐Nam Lim, Jun Ho Ji, Kyung A. Kwon, Gyeong‐Won Lee, Jae Hoon Lee,
Cancer Communications.2019; 39(1): 1. CrossRef
Changing trends in lymphoid neoplasm distribution in South Korea: analysis of 8615 cases from a single institute, 1997–2016
Jongmin Sim, Takuya Takayama, Junhun Cho, Seok Jin Kim, Won Seog Kim, Howe J. Ree, Young Hyeh Ko
Medicine.2019; 98(45): e17641. CrossRef
Non‐Hodgkin lymphoma in South East Asia: An analysis of the histopathology, clinical features, and survival from Thailand
Tanin Intragumtornchai, Udomsak Bunworasate, Kitsada Wudhikarn, Arnuparp Lekhakula, Jakrawadi Julamanee, Kanchana Chansung, Chittima Sirijerachai, Lalita Norasetthada, Weerasak Nawarawong, Archrob Khuhapinant, Noppadol Siritanaratanakul, Tontanai Numbenja
Hematological Oncology.2018; 36(1): 28. CrossRef
Prevalence and Implications of Bone Marrow Involvement in Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
Sang Il Choi, Myeong-Cherl Kook, Sanghyun Hwang, Young-Il Kim, Jong Yeul Lee, Chan Gyoo Kim, Il Ju Choi, Hyewon Lee, Hyeon Seok Eom, Soo-Jeong Cho
Gut and Liver.2018; 12(3): 278. CrossRef
A Case of Synchronous Lung Squamous Cell Carcinoma and Diffuse Large B-cell Lymphoma
Seung Jae Lee, Si Young Lim, Tae Kyung Yoo, Seul Ki Kim, You Gyung Kim, Hyun Joo Lee, Jae Uk Song
The Korean Journal of Medicine.2018; 93(3): 300. CrossRef
A risk stratification model for nodal peripheral T-cell lymphomas based on the NCCN-IPI and posttreatment Deauville score
Ho-Young Yhim, Yong Park, Yeon-Hee Han, Sungeun Kim, Sae-Ryung Kang, Joon-Ho Moon, Ju Hye Jeong, Ho-Jin Shin, Keunyoung Kim, Yoon Seok Choi, Kunho Kim, Min Kyoung Kim, Eunjung Kong, Dae Sik Kim, Jae Seon Eo, Ji Hyun Lee, Do-Young Kang, Won Sik Lee, Seok M
European Journal of Nuclear Medicine and Molecular Imaging.2018; 45(13): 2274. CrossRef
Low-grade follicular lymphoma involvement of the bone marrow with a mixed paratrabecular, diffuse, and massive pattern expressing typical mantle cell lymphoma immunophenotype CD23−/FMC7+: a case report
Jaewook Kim, Ji-Hun Lim, Joseph Jeong, Seon-Ho Lee, Jae-Cheol Jo, Sang Hyuk Park
Blood Research.2018; 53(3): 261. CrossRef
Aspectos epidemiológicos, clínicos e anatomopatológicos do linfoma folicular em cães
Renata D. Mazaro, Isis P.J. Rizkallah, Flávia S. Luz, Douglas M. Lorensetti, Bruno Cogliati, Rafael A. Fighera
Pesquisa Veterinária Brasileira.2018; 38(9): 1772. CrossRef
Serious fungal infections in Korea
K. Huh, Y. E. Ha, D. W. Denning, K. R. Peck
European Journal of Clinical Microbiology & Infectious Diseases.2017; 36(6): 957. CrossRef
Epidural Lymphoma Mimicking Hematoma: A Case Report
Dong-Yeong Lee, Soon-Taek Jeong, Kun-Tae Kim, Jung-Wook Yang, Dong-Hee Kim
Journal of Korean Society of Spine Surgery.2017; 24(1): 49. CrossRef
Geographical Correlations between Indoor Radon Concentration and Risks of Lung Cancer, Non-Hodgkin’s Lymphoma, and Leukemia during 1999–2008 in Korea
Mina Ha, Seung-sik Hwang, Sungchan Kang, No-Wook Park, Byung-Uck Chang, Yongjae Kim
International Journal of Environmental Research and Public Health.2017; 14(4): 344. CrossRef
Platelet to lymphocyte ratio (PLR) retains independent prognostic significance in advanced stage marginal zone lymphoma patients treated with rituximab, cyclophosphamide, vincristine, and prednisone combination chemotherapy (R-CVP): Consortium for Improvi
Jeongkuk Seo, Won Seog Kim, Jin Seok Kim, Seok Jin Kim, Jae Hoon Lee, Jun Shik Hong, Gyeong-Won Lee, Sung Yong Oh, Ji-Hyun Lee, Dok Hyun Yoon, Won-Sik Lee, Hyo Jung Kim, Jae-Yong Kwak, Hye Jin Kang, Jae-Cheol Jo, Yong Park, Ho Sup Lee, Hyo-Jin Kim, Cheolw
Blood Research.2017; 52(3): 200. CrossRef
Treatment outcome and risk analysis for cataract after radiotherapy of localized ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma
Hee Hyun Park, Sea-Won Lee, Soo Yoon Sung, Byung Ock Choi
Radiation Oncology Journal.2017; 35(3): 249. CrossRef
The prognostic significance of CD11b+CX3CR1+ monocytes in patients with newly diagnosed diffuse large B-cell lymphoma
Ho-Young Yhim, Jeong-A Kim, Sun-Hye Ko, Youngrok Park, Eunjung Yim, Hee Sun Kim, Jae-Yong Kwak
Oncotarget.2017; 8(54): 92289. CrossRef
Epidural Lymphoma Mimicking Hematoma: A Case Report
Dong-Yeong Lee, Soon-Taek Jeong, Kun-Tae Kim, Jung-Wook Yang, Dong-Hee Kim
Journal of Korean Society of Spine Surgery.2017; 24(1): 49. CrossRef
A phase II study of oxaliplatin and prednisone for patients with relapsed or refractory marginal zone lymphoma: Consortium for Improving Survival of Lymphoma trial
Sung Yong Oh, Won Seog Kim, Jin Seok Kim, Yee Soo Chae, Gyeong-Won Lee, Hyeon Seok Eom, Hun Mo Ryoo, Suee Lee, Seok Jin Kim, Dok Hyun Yoon, Jong Ho Won, Junshik Hong, Jinny Park, Sang-Min Lee, Jung Yong Hong, Eunkyung Park, Hyo Jung Kim, Deok-Hwan Yang, H
Leukemia & Lymphoma.2016; 57(6): 1406. CrossRef
Diffuse Large B-Cell Lymphoma of the Peri-Implant Mucosa Mimicking Peri-Implantitis
Seong-Ho Jin, Gyeongsin Park, Youngkyung Ko, Jun-Beom Park
Journal of Oral Implantology.2016; 42(2): 220. CrossRef
The Roles of Radiotherapy and Chemotherapy in the Era of Multimodal Treatment for Early-Stage Nasal-Type Extranodal Natural Killer/T-Cell Lymphoma
Tae Hyung Kim, Jin Seok Kim, Yang-Gun Suh, Jaeho Cho, Woo-Ick Yang, Chang-Ok Suh
Yonsei Medical Journal.2016; 57(4): 846. CrossRef
Treatment outcomes of IMEP as a front-line chemotherapy for patients with peripheral T-cell lymphomas
Ji Young Lee, Sang Min Lee, Moon Young Choi, Ki Hyang Kim, Young Don Joo, Sung Nam Im, Won Sik Lee
Blood Research.2016; 51(3): 187. CrossRef
Immune reconstitution inflammatory syndrome versus non-immune reconstitution inflammatory syndrome lymphoma in HIV patients on antiretroviral therapy
Pyoeng Gyun Choe, Jinyong Park, Wan Beom Park, Tae Min Kim, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Sang Won Park, Hong Bin Kim, Nam Joong Kim, Myoung-don Oh, Kang Won Choe
International Journal of STD & AIDS.2016; 27(11): 1013. CrossRef
Clinical outcome and prognosis of patients with primary sinonasal tract diffuse large B-cell lymphoma treated with rituximab-cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy: a study by the Consortium for Improving Survival of Lympho
Gyeong-Won Lee, Se-Il Go, Seok-Hyun Kim, Junshik Hong, Yu Ri Kim, Sukjoong Oh, Sung-Yong Kim, Young Rok Do, Hyewon Lee, Soon Il Lee, Sung Hwa Bae, Sung Yong Oh, Moo Kon Song, Won-Sik Lee, Bohee Lee, Jin Seok Kim, Min Kyoung Kim, Hye Jin Kang, Jae-Sook Ahn
Leukemia & Lymphoma.2015; 56(4): 1020. CrossRef
Therapeutic comparison of Surgery combined with chemotherapy and chemotherapy alone for Primary Gastrointestinal Lymphoma: A single center study
Je Hun Kim, Ho Sup Lee, Jun Seop Lee, Jin Young Lee, Su Young Kim, Cheol Su Kim, Joung Wook Yang, Ga In You
Kosin Medical Journal.2015; 30(1): 29. CrossRef
A Case of Simultaneous Primary Gastric and Duodenal Mucosa-Associated Lymphoid Tissue Lymphoma after Therapeutic Endoscopy
Sun Hee Park, Jae Young Jang, Min A Park, Hyuck Kim, Young Woon Chang
Korean Journal of Medicine.2015; 89(1): 64. CrossRef
Clinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of Korean Patients
Hokyung Choung, Young A Kim, Namju Kim, Min Joung Lee, Sang In Khwarg
Korean Journal of Ophthalmology.2015; 29(5): 285. CrossRef
A Rare Case of Malignant Lymphoma Occurred at Spinal Epidural Space: A Case Report
Hyun-Jun Cho, Jang-Bo Lee, Junseok W. Hur, Sung-Won Jin, Tai-Hyoung Cho, Jung-Yul Park
Korean Journal of Spine.2015; 12(3): 177. CrossRef
Radiotherapy as an effective treatment modality for follicular lymphoma: a single institution experience
Seo Hee Choi, Jaeho Cho, Jin Seok Kim, June-Won Cheong, Chang-Ok Suh
Radiation Oncology Journal.2015; 33(4): 310. CrossRef
Current therapy of choice for cutaneous lymphomas: Complementary to the Japanese Dermatological Association/Japanese Skin Cancer Society guidelines
Keiji Iwatsuki, Toshihisa Hamada
The Journal of Dermatology.2014; 41(1): 43. CrossRef
The Role of Radiotherapy in the Treatment of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
Taek-Keun Nam, Jae-Sook Ahn, Yoo-Duk Choi, Jae-Uk Jeong, Yong-Hyeob Kim, Mee Sun Yoon, Ju-Young Song, Sung-Ja Ahn, Woong-Ki Chung
Cancer Research and Treatment.2014; 46(1): 33. CrossRef
Current Concepts in Primary Effusion Lymphoma and Other Effusion-Based Lymphomas
Yoonjung Kim, Chan Jeong Park, Jin Roh, Jooryung Huh
Korean Journal of Pathology.2014; 48(2): 81. CrossRef
Benign Indolent CD56-Positive NK-Cell Lymphoproliferative Lesion Involving Gastrointestinal Tract in an Adolescent
Jaemoon Koh, Heounjeong Go, Won Ae Lee, Yoon Kyung Jeon
Korean Journal of Pathology.2014; 48(1): 73. CrossRef
Peripheral T cell lymphoma in Asia
Sanghui Park, Young Hyeh Ko
International Journal of Hematology.2014; 99(3): 227. CrossRef
Characteristics of Cutaneous Lymphomas in Korea According to the New WHO-EORTC Classification: Report of a Nationwide Study
Jae Ho Han, Young-Hyeh Ko, Yun Kyung Kang, Wan-Seop Kim, Yoon Jung Kim, Insun Kim, Hyun-Jung Kim, Soo Kee Min, Chan-Kum Park, Chan-Sik Park, Bong-Kyung Shin, Woo Ick Yang, Young-Ha Oh, Jong Sil Lee, Juhie Lee, Tae Hui Lee, Hyekyung Lee, Ho Jung Lee, Yoon
Korean Journal of Pathology.2014; 48(2): 126. CrossRef
Epstein–Barr virus‐associated T/natural killer‐cell lymphoproliferative disorders
Sanghui Park, Young H. Ko
The Journal of Dermatology.2014; 41(1): 29. CrossRef
Overexpression of sphingosine-1-phosphate receptor 1 and phospho-signal transducer and activator of transcription 3 is associated with poor prognosis in rituximab-treated diffuse large B-cell lymphomas
Jin Ho Paik, Soo Jeong Nam, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim, Yoon Kyung Jeon
BMC Cancer.2014;[Epub] CrossRef
Clinicopathologic implication of A20/TNFAIP3 deletion in diffuse large B-cell lymphoma: an analysis according to immunohistochemical subgroups and rituximab treatment
Jin Ho Paik, Heounjeong Go, Soo Jeong Nam, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim, Yoon Kyung Jeon
Leukemia & Lymphoma.2013; 54(9): 1934. CrossRef
Clinical features and survival outcomes of patients with diffuse large B-cell lymphoma: analysis of web-based data from the Korean Lymphoma Working Party Registry
Hyeon Gyu Yi, Jin Seok Kim, Cheolwon Suh, Won Seog Kim, Jae-Yong Kwak, Jong-Seok Lee, Yang Soo Kim, Young Don Joo, Yoo Hong Min, Hong Ghi Lee, Sung-Soo Yoon, Jong-Ho Won, Seonyang Park, Hugh Chul Kim, Chul Soo Kim
Blood Research.2013; 48(2): 115. CrossRef
Epidemiologic overview of malignant lymphoma
Jooryung Huh
The Korean Journal of Hematology.2012; 47(2): 92. CrossRef
Gastrointestinal Lymphoma
Yoon Jung Lee, Jun Haeng Lee
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2012; 12(3): 158. CrossRef
Transformation of CD5-Negative Follicular Lymphoma into CD5-Positive Diffuse Large B-Cell Lymphoma: A Case Report
Hyeong Kug Kim, In Sung Cho, Hye Kyung Lee, Yong Hun Choi, Seong Min Cho, Hyun Jin Moon, Jin A Lee
Korean Journal of Medicine.2012; 83(2): 263. CrossRef
The Role of Radiotherapy for the Treatment of Gastric MALT Lymphoma
Jae-Sook Ahn, Taek-Keun Nam
Korean Journal of Medicine.2012; 83(6): 712. CrossRef
Pathophysiology of Gastric MALT Lymphoma
Gyeongsin Park, Chang Suk Kang
Korean Journal of Medicine.2012; 83(6): 689. CrossRef
CD44s and CD44v6 Are Predominantly Expressed in the Non-germinal Center B-Cell-like Type of Diffuse Large B-Cell Lymphomas
Kyueng-Whan Min, Young-Ha Oh, Chan-Kum Park, So-Dug Lim, Wan-Seop Kim
The Korean Journal of Pathology.2011; 45(6): 589. CrossRef

HPV Genotyping in Squamous Cell Carcinoma of Upper Aerodigestive Tract.: Young Kim, Eun Hui Jeong, Byung Woo Min, Sung Sun Kim, Yoo Duk Choi, Woon Jae Jung, Jong Hee Nam, Chang Soo Park; Korean J Pathol. 2010;44(5):483-487.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.483

3,542 View
23 Download
1 Crossref

Abstract PDF

BACKGROUND
Smoking and alcohol consumption are the main risk factors for squamous cell carcinoma of the upper aerodigestive tract (SCCUAT). However, human papillomavirus (HPV) has been etiologically linked with tonsillar squamous cell carcinoma (TSCC). Therefore, we investigated the etiologic role of HPV in the context of SCCUAT in Korea.
METHODS
Archival paraffin block samples from 136 cases previously diagnosed as SCCUAT were randomly selected. A commercial HPV DNA chip was used for HPV genotyping.
RESULTS
One hundred and seventeen cases were available after checking beta-globin (47 cases of tonsil and 70 of non-tonsil). A HPV-positive result (HPV 16 and 18) occurred in 13 cases of SCCUAT, and 12 cases were tonsil (25.5%, 12/47). Among the 12 HPV-positive patients with TSCC, nine were non-smokers and non-drinkers. Most HPV-negative patients with TSCC had a history of alcohol drinking and smoking (32/35, 91.4%). HPV infection status was not significantly associated with histological grade, clinical stage, or survival in patients with TSCC.
CONCLUSIONS
HPV infection was significantly higher in patients with TSCC among those with SCCUAT. HPV may be independent risk factor in development of TSCC, such as smoking and alcohol drinking.

Citations

Citations to this article as recorded by

Prevalence of high-risk human papillomavirus and its genotype distribution in head and neck squamous cell carcinomas
Yuil Kim, Young-Hoon Joo, Min-Sik Kim, Youn Soo Lee
Journal of Pathology and Translational Medicine.2020; 54(5): 411. CrossRef

Korean Pediatric/Adolescent Lymphoma: Incidence and Pathologic Characteristics.: Seung Sook Lee, Jin Man Kim, Young Hyeh Ko, Jooryung Huh, Chang Suk Kang, Chul Woo Kim, Yun Kyung Kang, Jai Hyang Go, Min Kyung Kim, Wan Seop Kim, Yoon Jung Kim, Hyun Jung Kim, Hee Kyung Kim, Jong Hee Nam, Hyung Bae Moon, Chan Kum Park, Tae In Park, Young Ha Oh, Dong Wha Lee, Jong Sil Lee, Juhie Lee, Hyekyung Lee, Sung Chul Lim, Kyu Yun Jang, Hee Kyung Chang, Yoon Kyung Jeon, Hye Ra Jung, Min Sun Cho, Hee Jeong Cha, Suk Jin Choi, Jae Ho Han, Sook Hee Hong, Insun Kim; Korean J Pathol. 2010;44(2):117-124.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.2.117

4,764 View
72 Download
1 Crossref

Abstract PDF

BACKGROUND
The Hematopathology Study Group of the Korean Society of Pathologists conducted a nation-wide retrospective analysis of Korean pediatric lymphoma, to provide pathologic data on pediatric/adolescent lymphoma subtypes and features.
METHODS
All lymphoma cases of all age groups were collected during a recent 2 year-period (2005-2006) from 32 institutes in Korea. Among 3,686 lymphoma patients, 142 who were age 18 or less were classified according to the World Health Organization (WHO) classification.
RESULTS
Among 142 pediatric/adolescent lymphoma patients, Hodgkin lymphoma accounted for 21 (14.8%) and non-Hodgkin lymphoma (NHL) for 121 (85.2%). Hodgkin lymphoma appears to be more common in the pediatric/adolescent age group than in the all-ages group (14.8% vs 4.4%). T- and natural killer cell-NHL was more common in the pediatric/adolescent age group than in the all ages group (46.3% vs 22%). The majority of Korean pediatric/adolescent NHL cases was composed of Burkitt lymphoma, T- or B-lymphoblastic lymphoma, anaplastic large-cell lymphoma, and diffuse large B-cell lymphoma. For lymphoma patients under the age of 6 years, most had B-lymphoblastic or Burkitt lymphoma, which commonly presented at extranodal sites.
CONCLUSIONS
The distribution of lymphoma subtypes in the pediatric/adolescent age group is quite different from the distribution of adults, but it was quite similar to distribution in Western countries.

Citations

Citations to this article as recorded by

A Case of Nasal Type Extranodal NK/T Cell Lymphoma Incidentally Detected in a Child
Ha Jin Oh, Sang Hyun Park, Hae In Jang, Dong Hoon Lee, Yoo Duk Choi, Hee Jo Baek, Hoon Kook
Clinical Pediatric Hematology-Oncology.2015; 22(1): 76. CrossRef

Cytologic Diagnosis of Malignant Pleural Effusion in Multiple Myeloma: Two Case Reports.: Yoo Duk Choi, Sung Sun Kim, Chang Woo Han, Ji Shin Lee, Jong Hee Nam, Sang Woo Juhng, Chan Choi; Korean J Pathol. 2009;43(4):382-385.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.4.382

3,564 View
46 Download
3 Crossref

Abstract PDF

Malignant pleural effusion in multiple myeloma (MM) is extremely rare and is associated with poor prognosis. We experienced two cases of MM IgA type with malignant pleural effusion. The diagnoses were based on characteristic cytology and CD138 immunocytochemistry. The patients received several cycles of combination chemotherapy, since symptoms were more aggressive with an uncontrolled pleural effusion. We review the clinical features of these cases and literature concerning myelomatous pleural effusion.

Citations

Citations to this article as recorded by

Características de los pacientes con derrame pleural mielomatoso. Revisión sistemática
V. Riveiro, L. Ferreiro, M.E. Toubes, A. Lama, J.M. Álvarez-Dobaño, L. Valdés
Revista Clínica Española.2018; 218(2): 89. CrossRef
Characteristics of patients with myelomatous pleural effusion. A systematic review
V. Riveiro, L. Ferreiro, M.E. Toubes, A. Lama, J.M. Álvarez-Dobaño, L. Valdés
Revista Clínica Española (English Edition).2018; 218(2): 89. CrossRef
A 76-Year-Old Man With Anemia, Bone Pain, and Progressive Dyspnea
Thitiporn Suwatanapongched, Prapaporn Pornsuriyasak, Wasana Kanoksil, Thotsaporn Morasert, Warapat Virayavanich
Chest.2014; 145(4): 913. CrossRef

Analysis of HPV-other Samples by Performing HPV DNA Sequencing.: Yoo Duk Choi, Chang Woo Han, Woon Jae Chung, Woon Won Jung, Ji Shin Lee, Jong Hee Nam, Min Cheol Lee, Sang Woo Juhng, Ho Sun Choi, Chang Soo Park; Korean J Pathol. 2009;43(3):250-253.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.3.250

4,354 View
46 Download
7 Crossref

Abstract PDF

BACKGROUND
HPV-other samples are designated as being positive on HPV-PCR, but negative when using specific HPV hybridization probes. We wanted to determine the types on the HPV-other samples by performing sequencing, and to know the pathologic status of the uterine cervix according to the HPV type detected on sequencing.
METHODS
For HPV genotying, we used the commercially available HPV DNA Chip test, which contains 15 types of high-risk HPV and 9 types of low-risk HPV. The HPV DNA sequencing was performed for the HPV-other samples of 209 patients who subsequently underwent cervical biopsy.
RESULTS
For 204 of the 209 samples, the HPV types detected by sequencing were absent types at used HPV DNA chip. For the remaining 5 samples, sequencing was impossible due to mixed peaks. HPV-81 (19.6%), HPV-61 (18.6%), HPV-62 (16.7%) and HPV-84 (13.9%) were frequently detected. For the HPV-81, -62, -71, and -72 samples, most of the samples displayed normal or LSIL. However, HPV-84 and -61 were more associated with HSIL or worse, as compared to the other types.
Conclusion
HPV-81, -61, -62 and -84 were frequently found on sequencing analysis of the HPV-other samples. The pathologic status was diverse, according to the HPV type detected on sequencing.

Citations

Citations to this article as recorded by

Changes in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection
Yong-Hong Dong, Yu-Hua Luo, Chen-Jian Liu, Wen-Yu Huang, Lin Feng, Xing-Yuan Zou, Jin-Yan Zhou, Xiao-Ran Li
Journal of Translational Medicine.2024;[Epub] CrossRef
Cervical Dysplasia, Infection, and Phylogeny of Human Papillomavirus in HIV‐Infected and HIV‐Uninfected Women at a Reproductive Health Clinic in Nairobi, Kenya
Agnes Omire, Nancy L. M. Budambula, Leah Kirumbi, Hillary Langat, Danvas Kerosi, Washingtone Ochieng, Raphael Lwembe, Jorge F. Quarleri
BioMed Research International.2020;[Epub] CrossRef
Molecular characterisation of genital human papillomavirus among women in Southwestern, Nigeria
Yewande T. Nejo, David O. Olaleye, Georgina N. Odaibo, Jason Blackard
PLOS ONE.2019; 14(11): e0224748. CrossRef
Sequencing analysis of HPV-other type on an HPV DNA chip
Min-Jeong Kim, Jin Ju Kim, Sunmie Kim
Obstetrics & Gynecology Science.2018; 61(2): 235. CrossRef
Molecular epidemiology and genotype distribution of Human Papillomavirus (HPV) among Arab women in the state of Qatar
Devendra Bansal, Asha A Elmi, Sini Skariah, Pascale Haddad, Laith J Abu-Raddad, Aysha H Al Hamadi, Nady Mohamed-Nady, Nahla M Affifi, Randa Ghedira, Elham Hassen, Asma AJ Al-Thani, Afaf AHM Al-Ansari, Ali A Sultan
Journal of Translational Medicine.2014;[Epub] CrossRef
HPV Prevalence and Detection of Rare HPV Genotypes in Hong Kong Women from Southern China with Cytological Abnormalities
Ngai Na Chloe Co, Lai-On Chu, Joseph K. F. Chow, Joseph W. O. Tam, Enders K. O. Ng
ISRN Virology.2013; 2013: 1. CrossRef
Type-specific prevalence of high-risk human papillomavirus by cervical cytology and age: Data from the health check-ups of 7,014 Korean women
Min-Jeong Kim, Jin Ju Kim, Sunmie Kim
Obstetrics & Gynecology Science.2013; 56(2): 110. CrossRef

Solitary Splenic Metastases from Uterine Cervical Cancer: Case Reports and Review of the Literature.: Jo Heon Kim, Yoo Duk Choi, Jae Hyuk Lee, Jong Hee Nam, Sang Woo Juhng, Yang Seok Koh, Chol Kyoon Cho, Chan Choi; Korean J Pathol. 2008;42(5):317-322.

1,949 View
23 Download

Abstract PDF: Splenic metastasis from gynecologic tumors is extremely rare, especially in the absence of apparent disease at other sites. We report two patients that underwent splenectomy for a solitary splenic metastasis from uterine cervical carcinoma. In case 1, a 54-year-old woman with FIGO Stage IIb squamous cell carcinoma of the uterine cervix treated with radiotherapy and chemotherapy developed a solitary splenic metastasis 10 months after initial treatment. In case 2, a 46-year-old woman with FIGO Stage IIb adenocarcinoma of the uterine cervix treated with radiotherapy and chemotherapy was found to have a solitary splenic metastasis 11 months after treatment. Thus all abdominal organs including the spleen must be evaluated for metastases during follow-up of gynecologic tumors.

Tetranucleotide Repeat Microsatellite Instability in Uterine Cervical Carcinomas.: Yoo Duk Choi, Ji Shin Lee, Chan Choi, Chang Soo Park, Sang Woo Juhng, Ho Sun Choi, Jong Hee Nam; Korean J Pathol. 2007;41(1):30-37.

1,934 View
17 Download

Abstract PDF: BACKGROUND
Elevated levels of microsatellite alterations at selected tetranucleotide repeat regions (EMAST) have been recently described, and they are a distinct type of microsatellite instability (MSI). We investigated the prevalence of EMAST in squamous cell carcinoma (SCC) of the uterine cervix and we determined the correlation between EMAST and the clinicopathologic parameters, HPV infection and the p53 mutation.
METHODS
We examined the 3 mono-, 3 di-, and 5 tetranucleotide repeat markers in 47 cases of SCC, and we performed immunohistochemical staining for p53. HPV detection and genotyping was performed using a commercially available HPV DNA chip.
RESULTS
Thirteen out of 47 cases (27.7%) were EMAST(+) with at least one of five tetranucleotide repeat markers. However, MSI at mono- and dinucleo- tide markers was noted in only one case (2.1%). EMAST was not related with stage, size, lymph node metastasis, vascular/lymphatic invasion or the depth of invasion. Positive immunostaining for p53 was significantly more common in EMAST(+) tumors than in the EMAST(-) tumors (p=0.04). HPV-infection was positive in 32 cases. EMAST was not correlated with the state of HPV infection state or the HPV genotype.
CONCLUSIONS
27.7% of the invasive SCCs of the uterine cervix exhibited EMAST, and EMAST in the SCC of the uterine cervix was significantly associated with the p53 mutation.

Clonal Analysis of Neurofibroma by PCR Amplification of HUMARA Gene.: Jae Hyuk Lee, Seung Sang Han, Hyun Sik Oh, Yoo Duk Choi, Hyun Joong Kim, Kyung Hwa Lee, Jong Hee Nam, Chan Choi, Sang Woo Juhng; Korean J Pathol. 2003;37(6):421-428.

1,755 View
13 Download

Abstract PDF: BACKGROUND
While neurofibromas have generally been regarded as polyclonal hyperplastic lesions, it remains unclear whether the tumor is a true neoplasm or a hyperplastic lesion.
METHODS
Determination of clonality by X chromosome inactivation pattern was investigated in twenty-one cases of neurofibroma employing enzyme digestion and PCR of the HUMARA gene. The histological, immunohistochemical, and ultrastructural characteristics of the tumors were also examined.
RESULTS
Immunohistochemically, most of the tumor cells showed vimentin and S-100 protein positivity. Axons were demonstrated by neurofilament protein positivity and were seen mainly at the periphery and rarely in the central portion of the tumor. Ultrastructurally, the tumors were composed of a variety of cell types: perineurial cells, Schwann cells, fibroblasts, and axons. X chromosome inactivation analysis was completed on thirteen out of fifteen cases in which DNA was successfully extracted. Of thirteen neurofibromas that were heterozygous at the HUMARA loci, eleven showed a polyclonal pattern. The remaining two cases were considered as indeterminate for clonality because of unequal band intensity and failure to obtain the normal control DNA.
CONCLUSION
The results from this study suggest that neurofibromas are polyclonal in origin and might be a neoplastic lesion comprising non-neoplastic cells among constituent components.

Stromelysin-3 Expression in Squamous Intraepithelial Lesions and Invasive Squamous Cell Carcinoma of the Uterine Cervix.: Yoo Duk Choi, Eun Jung Park, Jong Hee Nam, Chang Soo Park; Korean J Pathol. 2002;36(6):389-393.

1,800 View
15 Download

Abstract PDF: BACKGROUND
Matrix metalloproteinase (MMP) plays an important role in the invasion and metastasis of epithelial neoplasms. Currently, detected stromelysin-3 (ST-3) (MMP-11) is thought to be associated with invasiveness in epithelial neoplasms. However, the study of the expression of stromelysin-3 in the uterine cervix is yet to be delineated.
METHODS
Stromelysin-3 expression in cervical invasive squamous cell carcinoma (SCC) and in squamous intraepithelial lesions (SIL) having potentiality to become invasive was studied by immunohistochemical analysis. We examined the correlation between ST-3 expression and the histopathological parameters of the invasive carcinoma, including growth pattern, lymph node involvement, and degrees of differentiation.
RESULTS
The stromelysin expression rates were as follows; 8.3% in low grade SIL (LSIL), 18.9% in High grade SIL (HSIL), and 75.6% in SCC. A statistical difference in the expression difference was exhibited only between invasive SCC and SIL, but not between LSIL and HSIL, even though HSIL showed a higher expression rate than LSIL. No significant association was found in invasive SCC between ST-3 expression and histopathological parameters.
CONCLUSIONS
ST-3 expression is associated with tumor invasiveness in squamous lesions of the uterine cervix and not with histopathological parameters in invasive SCC.

Clonality Study in Carcinosarcomas and Malignant Mixed Epithelial Tumors.: Eun Jung Park, Yoo Duk Choi, Jong Hee Nam, Min Cheol Lee, Chang Soo Park, Sang Woo Juhng, In Seon Choi, Kyung Hee Kim, Chan Choi; Korean J Pathol. 2002;36(4):205-211.

1,765 View
13 Download

Abstract PDF: BACKGROUND
Tumors are usually considered to be clonal progeny of single transformed cells. Carcinosarcomas and malignant mixed epithelial tumors are examples where controversies exist regarding the singularity or multiplicity of their cell of origin.
METHODS
The authors examined the clonality of carcinosarcomas (7 cases) and malignant mixed epithelial tumor (5 cases) in female patients by X-chromosome inactivation as a marker. Each component of the tumors were picked up by the laser capture microscope. The polymorphic exon 1 CAG trinucleotide repeat in the X-linked human androgen receptor (HUMARA) gene was amplified by a polymerase chain reaction before and after treatment of the methylation-sensitive endonuclease HpaII.
RESULTS
Eleven cases were informative for clonality determination. Six out of seven carcinosarcomas and three out of four malignant mixed epithelial tumors revealed the same patterns of X-chromosome inactivation, which suggests that they are monoclonal. In contrast, the patterns of X-chromosome inactivation were different between the two tumor components in each cases of carcinosarcoma and malignant mixed epithelial tumor, indicating that they are of polyclonal origin.
CONCLUSIONS
These observations show that although most of carcinosarcomas and malignant mixed epithelial tumors are of monoclonal origin, some of them are of polyclonal origin. This finding suggests that these tumors are genuinely polyclonal, and that they originated in the neoplastic transformation of more than one somatic cells

Mesoblastic Nephroma of Adulthood.: Jae Woo Park, Jae Hun Chung, Jae Hyuk Lee, Jong Hee Nam, Chan Choi, Min Cheol Lee, Chang Soo Park, Sang Woo Juhng; Korean J Pathol. 2001;35(6):551-554.

1,817 View
10 Download

Abstract: Mesoblastic nephroma is a benign neoplasm of the kidney, which is usually diagnosed during the first six months of life. Incidence in adults is exceedingly rare. We report herein a case of mesoblastic nephroma that occurred in the upper pole of the right kidney of a 39-year-old woman. It was a round mass measuring 3X3X2 cm in dimension. Microscopically, it consisted of uniform spindle cells with foci of hyalinization and dystrophic calcification. Tubular structures were entrapped in the tumor. Upon immunohistochemical staining, the spindle cells were found to be positive for smooth muscle actin, desmin, and vimentin. The epithelial cells of the entrapped tubules were positive for cytokeratin. On electron microscopic examination, the spindle cells demonstrated smooth muscle differentiation identified by indented nuclei, microfilaments beneath the cell membrane, dense bodies, and basal lamina-like materials.

Does the Colorectal Cancer Among Koreans Share the Same Pathological Features by Geographical Distribution: A Nationwide Survey of Surgically Resected 1,676 Cancers from 1,602 Patients.: Mee Soo Chang, Jin Hee Sohn, Dae Young Kang, Gyeong Hoon Kang, Myung Sook Kim, Woo Ho Kim, Jong Hee Nam, Woo Sung Moon, Sun Hoo Park, Cheol Jeun Park, Ro hyun Sung, Young Lyun Oh, Eun Sook Chang, Hee Kyung Chang, Mee Yon Cho, Kyung Ja Cho, Yong Il Kim; Korean J Pathol. 2001;35(1):14-19.

1,961 View
15 Download

Abstract PDF: BACKGROUND
This nationwide survey was undertaken to characterize the general pathological features of colorectal cancer in Korea, and especially to elucidate the geographical characteristics by means of their anatomical distribution.
METHODS
We analysed 1,676 colorectal cancers (from 1,602 patients) surgically resected in 1998 at 15 institutions from nine geographical sites in Korea.
RESULTS
The topographic incidence of colorectal cancer in seven out of the total nine geographical sites, was the highest in the rectum (32-54%); and those from Wonju and Cheongju were in the sigmoid colon (28% for both). The right colon cancer incidence was 42% in Wonju and 36% in Cheongju, while it was 17-22% in the other areas. The cecal cancer incidences in Wonju and in Taegu were 7% and 8%, respectively, but 0-4% in the other areas. As for histology, moderately differentiated adenocarcinoma was the most frequent (46-84%), except for in Wonju and Chonju, where the most predominant type was well differentiated (63% and 52%, respectively).
CONCLUSION
The incidence of right colon cancer was higher in Wonju and Cheongju, than in the other geographical sites. The cecal predilection was prominent in Taegu and Wonju. The Elucidation of geographical differences in degree of differentiation for tubular adenocarcinoma seems to require further cumulative study with strict guidelines.

The Bethedsa System 2001 Workshop Report.: Eun Kyung Hong, Jong Hee Nam, Moon Hyang Park; Korean J Cytopathol. 2001;12(1):1-15.

1,650 View
15 Download

Abstract PDF: The Bethesda System (TBS) was first developed in 1988 for the need to enhance the communication of the cytopathologic findings to the referring physician in unambiguous diagnostic terms. The terminology used in this reporting system should reflect current understanding of the pathogenesis of cervical/vaginal disease, so the framework of the reporting system should be flexible enough to accommodate advances in medicine, including virology, molecular biology, and pathology. Three years after the introduction of TBS, the second Bethesda workshop was held to set or amend diagnostic criteria for each categories of TBS. TBS 1991 is now widely used. The third Bethesda workshop, The Bethesda System 2001 Workshop, was held in National Cancer Institute, Bethesda, Maryland from April 30 to May 2, 2001. Again, the goals of this workshop were to promote effective communication and to clarify in reporting cervical cytopathology results to clinicians and to provide with the information to make appropriate decisions about diagnosis and treatment. Nine forum groups were made and there were Web-based bulletin board discussions between October, 2000 and the first week of April, 2001. On the basis of bulletin board comments and discussions, the forum moderators recommended revised terminologies in the Workshop. Hot discussions were followed after the presentation by forum moderators during the workshop. Terminologies confusing clinicians and providing no additional informations regarding patient management were deleted in the workshop to clarify the cervicovaginal cytology results. Any informations related to the patient management were encouraged to add. So 'Satisfactory for evaluation but limited by' of 'Specimen Adequacy' catergory was deleted. Terminology of 'Unsatisfactory' was further specified as 'Specimen rejected' and 'Specimen processed and examined, but unsatisfactory'. Terminologies of 'Benign Cellular Change' and 'Within Normal Limits' were combined and terminology was changed to 'Negative for intraepithelial lesion

Malignant Granular Cell Tumor of the Shoulder: A case report.: Jae Hun Chung, Jae Hyuk Lee, Jong Hee Nam, Chan Choi, Min Cheol Lee; Korean J Pathol. 2000;34(6):475-479.

1,972 View
15 Download

Abstract PDF: A malignant granular cell tumor (MGCT) occurred in the left shoulder of a 62-year-old man. The patient underwent wide marginal excision followed by chemotherapy and radiotherapy. A metastatic tumor was identified in the axillary lymph node 22 months after the excision of the shoulder mass. The primary tumor was a poorly circumscribed mass measuring 5 5 4 cm. On cut section, it was a solid mass with yellowish tan color. Histologically, both primary and metastatic tumor consisted of polygonal cells with abundant granular cytoplasm and a vesicular nucleus with a prominent nucleolus. Two to three mitotic figures per ten high power fields at 200 were counted. Tumor cells were weakly stained with periodic acid-Schiff (PAS) preparation both before and after diastase digestion, and were positive for S-100 protein, neuron-specific enolase (NSE), and vimentin. By electron microscopy, the cytoplasm was filled with numerous autophagolysosomes containing myelin figures, mitochondria, and fragmented rough endoplasmic reticula. Basal laminae and angulated bodies were also noted. These findings suggest schwannian differentiation of this tumor.

Detection of Human Papillomavirus in Lesions of Uterine Cervix Immunohistochemistry and in situ Hybridization.: Chang Soo Park, Jong Hee Nam, Jae Hyuk Lee, Jong Soon Kim, Seung Jin Oh; Korean J Pathol. 1997;31(4):289-297.

1,890 View
14 Download

Abstract PDF: To evaluate the detection of HPV DNA according to subtype of lesions of uterine cervix and its clinical applicability, in situ hybridization (ISH) and immunohistochemistry for HPV were performed in 189 cases of uterine cervical lesion, including 23 cases of low grade squamous intraepithelial lesion (SIL), 115 cases of high grade SIL and 51 cases of invasive carcinoma. Positive immunostaining, brown precipitate, was mainly noted in the nucleus of koilocytes in the superficial and intermediate layer. Positivity of immunostaining was 21.7% in low grade SIL, 13.0% in high grade SIL and 9.8% in invasive carcinoma. Positive reaction in ISH, red precipitate, was noted in the nucleus of not only koilocytes but also non-koilocytes in the superficial and intermediate layer, and dot precipitate was rarely identified in the nest of squamous cell carcinoma. Based on HPV subtype, 6/11 was 21.7% in low grade SIL, 16/18 was 32.2% and 39.2% in high grade SIL and invasive carcinoma, respectively. With regard to their associated HPV types, low grade SILs were heterogeneous and high grade SILs and invasive carcinomas were related with the high oncogenic risk group only. The correlation of HPV subtypes with panHPV was 91.3% in low grade SIL, 91.3% in high grade SIL and 98.0% in invasive carcinoma. These results suggest that detection of HPV infection by ISH may be a more useful method than immunohistochemistry and application of the HPV subtype probe with the panHPV probe could improve the sensitivity of ISH.

A Study of the Correlation between Expression of c-erbB-2 Oncoprotein and Various Clinicopathological Prognostic Factors in Breast Carcinoma.: Jong Hee Nam, Kyung Soo Kim, Chang Soo Park, Sang Woo Juhng; Korean J Pathol. 1995;29(2):136-144.

1,508 View
12 Download

Abstract PDF: Immunohistochemical study for c-erbB-2 oncoprotein was performed on paraffin sections of 76 primary breast carcinomas to determine the relationship between expression of c-erbB-2 and various clinicopathological prognostic indicators, including the expression of epidermal growth factor receptor (EGFR). Positive reaction for c-erbB-2 oncoprotein revealed an intense red granular staining predominantly located at the tumor cell membrane, with some cells exhibiting a weak cytoplasmic staining as well. The epithelial cells of the normal lobule and duct showed a negative reaction. Positive reaction for EGFR revealed a granular staining in the cytoplasm and the cell membrane of the tumor cells. Some tumors showed a positive EGFR staining in the epithelial cells of normal duct and lobule. Twenty six of 76 cases (34.2%) of primary breast carcinomas revealed a positive reaction for c-erbB-2 oncoprotein, and 28 cases (36.8%) were positive for EGFR. Expression of c-erbB-2 oncoprotein and EGFR was evident in 37.7% and 40.6% of 69 classic invasive ductal carcinomas, respectively. None of the other histological types showed a positive reaction. Expression of c-erbB-2 oncoprotein was strongly associated with tumor size(p=0.0015), histologic grade(.p=0.0175), vascular invasion(p=0.0043), and lymph node metastasis(p=0.0024), but not with age at diagnosis(p=0.1836). No significant association was found between expression of c-erbB-2 oncoprotein and EGFR. Co-expression of c-erbB-2 oncoprotein and EGFR was also strongly associated with tumor size (p=0.0029). These results suggest that c-erbB-2 oncoprotein is biologically distinct from EGFR, and may be used as a prognostic indicator of breast carcinoma due to its strong association with various clinicopathological prognostic factors.

Cytopathologic Observation of Primary Malignant Melanoma of the Lung: A case report.: Yun Mee Kim, Jong Hee Nam, Min Cheol Lee, Joo Yong Yoo, Kyu Hyuk Cho; Korean J Pathol. 1991;25(4):367-375.

1,816 View
17 Download

Abstract PDF: The pulmonary cytology has reached a high level of accuracy. By the examination of the sputum and/or bronchial brushings, it is now possible to make a diagnosis in 70% to 90% of patients with cancer. Primary melanoma of the lung is very rare and there have been reported about 20 cases in the world literature. We present a case of primary malignant melanoma of the lung in a 61-year-old male diagnosed by cytologic examination of sputum, bronchial brushing and aspirated pleural fluid. Histologic examination of bronchoscopic biopsy and examination of the skin and other primary sites confirmed the diagnosis.

Author index