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Bang Hur 1 Article
Expression of MUC1 and MUC4 in Gallbladder Adenocarcinoma
Su-Mi Kim, Sun-Ju Oh, Bang Hur
Korean J Pathol. 2012;46(5):429-435.   Published online October 25, 2012
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AbstractAbstract PDF

Recent reports have indicated that overexpression of mucin (MUC) 1 and/or MUC4 correlates with the occurrence and progression of extra-hepatobiliary malignancy. In this study, we investigated the expression of MUC1 and MUC4 and their prognostic significance in gallbladder adenocarcinoma.


We examined 54 surgical gallbladder adenocarcinoma samples by immunohistochemistry for MUC1 and MUC4 expression. Staining was evaluated as a sum score of extent and intensity, dividing the samples into low and high expression groups.


The low expression group for both MUC1 and MUC4 was 10 samples (18.5%), and the high expression group was 44 samples (81.5%). High MUC1 expression was significantly correlated with more differentiated tumors (p=0.033), whereas high expression of MUC4 correlated with negative nodal status (p=0.012). Other pathological features were not correlated with MUC expression. Multivariate cox regression analysis showed that neither MUC1 nor MUC4 expression correlated with survival.


Although there were some correlations found, a prognostic role for either MUC1 or MUC4 expression in gallbladder carcinoma was not identified in this study. Further investigation is required.


Citations to this article as recorded by  
  • Expression of Mucoproteins in Gallbladder Cancer
    Puneet Kumar, Priyesh Shukla, Soni Kumari, Ruhi Dixit, Gopeshwar Narayan, V. K. Dixit, A. K. Khanna
    Indian Journal of Surgery.2022; 84(3): 456.     CrossRef
  • Prognostic and clinicopathological value of MUC1 expression in colorectal cancer
    Chao Li, Tao Liu, Libin Yin, Didi Zuo, Yuyang Lin, Lei Wang
    Medicine.2019; 98(9): e14659.     CrossRef
  • Prognostic Significance of Mucin Antigen MUC1 in Various Human Epithelial Cancers
    Feng Xu, Fuquan Liu, Hongwei Zhao, Guangyu An, Guosheng Feng
    Medicine.2015; 94(50): e2286.     CrossRef
  • Increased Expression of CCN2, Epithelial Membrane Antigen, and Fibroblast Activation Protein in Hepatocellular Carcinoma with Fibrous Stroma Showing Aggressive Behavior
    Gi Jeong Kim, Hyungjin Rhee, Jeong Eun Yoo, Jung Eun Ko, Jee San Lee, Hyunki Kim, Jin Sub Choi, Young Nyun Park, Philip C. Trackman
    PLoS ONE.2014; 9(8): e105094.     CrossRef
  • State-of-the-art in the management of locally advanced and metastatic gallbladder cancer
    Mairéad G. McNamara, Cristiane Metran-Nascente, Jennifer J. Knox
    Current Opinion in Oncology.2013; 25(4): 425.     CrossRef
  • Clinicopathological and Prognostic Significance of MUC-2, MUC-4 and MUC-5AC Expression in Japanese Gastric Carcinomas
    Li-Jun Xiao, Shuang Zhao, En-Hong Zhao, Xin Zheng, Wen-Feng Gou, Ya-Nan Xing, Yasuo Takano, Hua-Chuan Zheng
    Asian Pacific Journal of Cancer Prevention.2012; 13(12): 6447.     CrossRef

JPTM : Journal of Pathology and Translational Medicine