Journal of Pathology and Translational Medicine

Chong Jai Kim

10 Articles

Wharton Jelly Hair in a Case of Umbilical Cord Stricture and Fetal Death: Eun Na Kim, Jae-Yoon Shim, Chong Jai Kim; J Pathol Transl Med. 2019;53(2):145-147. Published online November 14, 2018; DOI: https://doi.org/10.4132/jptm.2018.10.24

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Placental and Umbilical Cord Anomalies Detected by Ultrasound as Clinical Risk Factors of Adverse Perinatal Outcomes. Case Series Review of Selected Conditions. Part 3: Vascular Anomalies of the Umbilical Cord and Fetoplacental Vascular Malperfusion
Gabriele Tonni, Mario Lituania, Gianpaolo Grisolia, Alessia Pinto, Maria Paola Bonasoni, Giuseppe Rizzo, Rodrigo Ruano, Edward Araujo Júnior, Heron Werner, Waldo Sepulveda, Gianluigi Pilu
Journal of Clinical Ultrasound.2025;[Epub] CrossRef
Histomorphometric analysis of Wharton's jelly size in pregnancies with normal and pre-eclamptic conditions, and its relation to baby weight
Ankit Jain, Rashmi Jain, Amarjyoti Chaturvedi
Indian Journal of Obstetrics and Gynecology Research.2024; 11(4): 647. CrossRef
Loss of Wharton's jelly and fibrosis in umbilical cord stricture area: A case report
Alžbeta Blichárová, Ľudmila Verbóová, Zuzana Benetinová, Tibor Mátyás, Richard Bašista, Vladimír Tancoš, Patrícia Kollárová
Journal of Forensic and Legal Medicine.2023; 96: 102512. CrossRef

Adrenal Cortical Neoplasm with Uncertain Malignant Potential Arising in the Heterotopic Adrenal Cortex in the Liver of a Patient with Beckwith-Wiedemann Syndrome: Eun Na Kim, Dong Eun Song, Hee Mang Yoon, Beom Hee Lee, Chong Jai Kim; J Pathol Transl Med. 2019;53(2):129-135. Published online November 26, 2018; DOI: https://doi.org/10.4132/jptm.2018.11.13

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Patients with Beckwith-Wiedemann syndrome (BWS) are predisposed to developing embryonal tumors, with hepatoblastoma being the most common type. Our patient showed hemihypertrophy, macroglossia, and paternal uniparental disomy in chromosome 11 and was diagnosed with BWS. When the patient was 9 months old, a 2.5×1.5 cm oval hypoechoic exophytic mass was detected in the inferior tip of his right liver. Preoperative imaging identified it as hepatoblastoma; however, histologic, immunohistochemistry, and electron microscopic findings were compatible with adrenal cortical neoplasm with uncertain malignant potential. The origin of the adrenal tissue seemed to be heterotopic. Here, we describe for the first time an adrenal cortical neoplasm with uncertain malignant potential arising in the heterotopic adrenal cortex located in the liver of a patient with BWS.

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Adrenocortical tumors and hereditary syndromes
Kanakamani Jeyaraman, Paola Concolino, Henrik Falhammar
Expert Review of Endocrinology & Metabolism.2025; 20(1): 1. CrossRef
Functional adrenocortical carcinoma with adrenohepatic fusion: A case report
Pastor Escárcega-Fujigaki, Guillermo Hernández-Peredo Rezk, José de Jesús Loeza- Oliva, Anallely Luna-Hernández, Bethsaida Natali Arreguín-Cortés, Rafael López-Cruz
Journal of Pediatric Surgery Case Reports.2024; 107: 102841. CrossRef
Molecular and Clinical Features of Adrenocortical Tumors in Beckwith–Wiedemann Spectrum
Diana Carli, Federico Rondot, Maria Luca, Anna Campello, Stefano Gabriele Vallero, Elisa Tirtei, Andrea Gazzin, Simona Cardaropoli, Francesca Montanari, Claudio Graziano, Paola Quarello, Abu Saadat, Angela Sparago, Giovanni Battista Ferrero, Franca Fagiol
Cancers.2024; 16(23): 3967. CrossRef
Beckwith–Wiedemann syndrome: Clinical, histopathological and molecular study of two Tunisian patients and review of literature
Hela Sassi, Yasmina Elaribi, Houweyda Jilani, Imen Rejeb, Syrine Hizem, Molka Sebai, Nadia Kasdallah, Habib Bouthour, Samia Hannachi, Jasmin Beygo, Ali Saad, Karin Buiting, Dorra H’mida Ben‐Brahim, Lamia BenJemaa
Molecular Genetics & Genomic Medicine.2021;[Epub] CrossRef
Adrenocortical Tumors in Children With Constitutive Chromosome 11p15 Paternal Uniparental Disomy: Implications for Diagnosis and Treatment
Emilia Modolo Pinto, Carlos Rodriguez-Galindo, Catherine G. Lam, Robert E. Ruiz, Gerard P. Zambetti, Raul C. Ribeiro
Frontiers in Endocrinology.2021;[Epub] CrossRef

Chronic Placental Inflammation as a Risk Factor of Severe Retinopathy of Prematurity: Chae Young Kim, Euiseok Jung, Eun Na Kim, Chong Jai Kim, Joo Yong Lee, Ji Hye Hwang, Woo Sun Song, Byong Sop Lee, Ellen Ai-Rhan Kim, Ki-Soo Kim; J Pathol Transl Med. 2018;52(5):290-297. Published online July 16, 2018; DOI: https://doi.org/10.4132/jptm.2018.07.09

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Background
Chronic placental inflammation (CPI) has been implicated in the pathogenesis of diseases in premature infants, whereas retinopathy of prematurity (ROP) is a major complication primarily affecting preterm and very low-birth-weight (VLBW) infants. This study aims to investigate the association between CPI and ROP in VLBW infants.
Methods
We performed a retrospective review of clinical records of VLBW infants born between 2013 and 2016. Placental pathology findings including CPI cases were analyzed using logistic regression to study infants’ morbidities and other clinical characteristics.
Results
A total of 402 infants with a mean (standard deviation) gestational age of 28.5 (2.8) weeks and birth weight of 1,027.2 (304.4) g were included. The incidence of ROP was 24.1%. CPI was found in 90 infants (22.4%), among which 28.9% (26 of 90) developed ROP, and 21.1% (19 of 90) underwent laser photocoagulation. Lower gestational age, lower birth weight, longer duration of oxygen supply, and presence of CPI were associated with the development of ROP. After adjustment for gestational age, birth weight, sex, duration of oxygen supply, and other overlapping placental pathology, CPI was associated with the odds for type 1 ROP that required laser photocoagulation (adjusted odds ratio, 2.739; 95% confidence interval, 1.112 to 6.749; p = .029).
Conclusions
CPI was associated with severe ROP requiring treatment with laser photocoagulation in VLBW infants.

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Comprehensive assessment of placental inflammation: Novel approach in predicting retinopathy of prematurity
Salma El Emrani, Esther J.S. Jansen, Jelle J. Goeman, Jacqueline U.M. Termote, Enrico Lopriore, Nicoline E. Schalij-Delfos, Lotte E. van der Meeren
Early Human Development.2025; 204: 106239. CrossRef
Histological Chorioamnionitis and Funisitis as New Risk Factors for Retinopathy of Prematurity: A Meta-analysis
Salma El Emrani, Esther J.S. Jansen, Jelle J. Goeman, Enrico Lopriore, Jacqueline U.M. Termote, Nicoline E. Schalij-Delfos, Lotte E. van der Meeren
American Journal of Perinatology.2024; 41(S 01): e3264. CrossRef
Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study
Sam Ebenezer Athikarisamy, Geoffrey C. Lam, Matthew N. Cooper, Tobias Strunk
Frontiers in Pediatrics.2023;[Epub] CrossRef
Identification of clinical factors associated with timing and duration of spontaneous regression of retinopathy of prematurity not requiring treatment
Jamee Schoephoerster, Sydney Roston, Scott Lunos, Sara E. Ramel, Jill Anderson, Michael K. Georgieff, Ellen C. Ingolfsland
Journal of Perinatology.2023; 43(6): 702. CrossRef
Ocular Vascular Diseases: From Retinal Immune Privilege to Inflammation
Xudong Wang, Tianxi Wang, Enton Lam, David Alvarez, Ye Sun
International Journal of Molecular Sciences.2023; 24(15): 12090. CrossRef
The potential of marine resources for retinal diseases: a systematic review of the molecular mechanisms
Kristin Krueger, Elke Boehme, Alexa Karina Klettner, Marietta Zille
Critical Reviews in Food Science and Nutrition.2022; 62(27): 7518. CrossRef
Retinopathy prematurity: a systematic review and meta-analysis study based on neonatal and maternal risk factors
Tahereh Bahmani, Arezoo Karimi, Nazanin Rezaei, Salman Daliri
The Journal of Maternal-Fetal & Neonatal Medicine.2022; 35(25): 8032. CrossRef
Diallyl Trisulfide Promotes Placental Angiogenesis by Regulating Lipid Metabolism and Alleviating Inflammatory Responses in Obese Pregnant Mice
Miaomiao Wang, Zhaoyu Wang, Yueyue Miao, Hongkui Wei, Jian Peng, Yuanfei Zhou
Nutrients.2022; 14(11): 2230. CrossRef
Risk factors for the development of retinopathy in premature infants
O.Yu. Obolonska, L.I. Vakulenko, L.P. Badogina, O.I. Obolonskyi, I.A. Likhachova, O.V. Kovryga
CHILD`S HEALTH.2022; 17(3): 138. CrossRef
Development of the genomic inflammatory index (GII) to assess key maternal antecedents associated with placental inflammation
Kirsi S. Oldenburg, Lauren A. Eaves, Lisa Smeester, Hudson P. Santos, T. Michael O'Shea, Rebecca C. Fry
Placenta.2021; 111: 82. CrossRef
Risk Factors Associated with Retinopathy of Prematurity in Very and Extremely Preterm Infants
Claudia Ioana Borțea, Florina Stoica, Marioara Boia, Emil Radu Iacob, Mihai Dinu, Roxana Iacob, Daniela Iacob
Medicina.2021; 57(5): 420. CrossRef
Efficacy of Aflibercept Treatment and Its Effect on the Retinal Perfusion in the Oxygen-Induced Retinopathy Mouse Model of Retinopathy of Prematurity
Sarina M. Amin, Andres Gonzalez, Jade Guevara, Charlotte Bolch, Lorick Andersen, W. Clay Smith, Swati Agarwal-Sinha
Ophthalmic Research.2021; 64(1): 91. CrossRef
A pilot randomised clinical trial of 670 nm red light for reducing retinopathy of prematurity
Alison L. Kent, Mohamed E. Abdel-Latif, Timothy Cochrane, Margaret Broom, Jane E. Dahlstrom, Rohan W. Essex, Bruce Shadbolt, Riccardo Natoli
Pediatric Research.2020; 87(1): 131. CrossRef
Human placental suppressors of cytokine signalling (SOCS) and inflammatory cytokines are dysregulated in assisted reproduction, advanced maternal age and pre-term birth
S. J. Knight, A. D. Smith, H. Kim, A. C. Collier
Clinical and Experimental Obstetrics & Gynecology.2020;[Epub] CrossRef
Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth
Jun Seok Son, Xiangdong Liu, Qiyu Tian, Liang Zhao, Yanting Chen, Yun Hu, Song Ah Chae, Jeanene M. de Avila, Mei‐Jun Zhu, Min Du
The Journal of Physiology.2019; 597(13): 3333. CrossRef
Cumulative evidence for association of sepsis and retinopathy of prematurity
Jichong Huang, Ying Tang, Tingting Zhu, Yafei Li, Hua Chun, Yi Qu, Dezhi Mu
Medicine.2019; 98(42): e17512. CrossRef

C-reactive Protein Overexpression in the Background Liver of Hepatitis B Virus–Associated Hepatocellular Carcinoma Is a Prognostic Biomarker: Jin Ho Shin, Eunsil Yu, Eun Na Kim, Chong Jai Kim; J Pathol Transl Med. 2018;52(5):267-274. Published online July 27, 2018; DOI: https://doi.org/10.4132/jptm.2018.07.14

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Background
Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC). Peripheral blood C-reactive protein (CRP) concentration and CRP overexpression in HCC cells are proven to be prognostic markers for HCC, but the significance of CRP expression in non-neoplastic hepatocytes, which are the primary origin of CRP, has not been studied. This study was conducted to determine the clinicopathologic significance of CRP immunoreactivity in the background liver of HBV-associated HCC.
Methods
CRP immunostaining was done on tissue microarrays of non-neoplastic liver tissues obtained from surgically resected, treatment-naïve HBV-associated HCCs (n = 156). The relationship between CRP immunoreactivity and other clinicopathologic parameters including cancer-specific survival was analyzed. CRP immunoreactivity was determined using a 4-tier grading system: grades 0, 1, 2, and 3.
Results
CRP was positive in 139 of 156 cases (89.1%) of non-neoplastic liver in patients with HCCs: grade 1 in 83 cases (53.2%); grade 2 in 50 cases (32.1%); and grade 3 in six cases (3.8%). The patients with diffuse CRP immunoreactivity (grade 3) had decreased cancer-specific survival (p = .031) and a tendency for shorter interval before early recurrence (p = .050). The degree of CRP immunoreactivity correlated with serum CRP concentration (p < .001).
Conclusions
CRP immunoreactivity in non-neoplastic liver is a novel biomarker for poor cancer-specific survival of HBV-associated HCC and correlates with serum CRP concentration.

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Plasma thrombomodulin is a valuable biomarker to predict the severity of hemorrhagic fever with renal syndrome caused by the Hantaan virus
Han-Dong Zhao, Yan Zhang, Xiao-Hong Wang, Hong-Bo Qian, Tong-Bo Yu, Peng Li, Kang-Xiao Ma, Hong-Li Liu
Frontiers in Cellular and Infection Microbiology.2025;[Epub] CrossRef
Analysis of Inflammatory and Thyroid Hormone Levels Based on Hepatitis A and B Virus Immunity Status: Age and Sex Stratification
Hyeokjun Yun, Jae-Sik Jeon, Jae Kyung Kim
Viruses.2024; 16(8): 1329. CrossRef
Ferritin and procalcitonin serve as discriminative inflammatory biomarkers and can predict the prognosis of severe fever with thrombocytopenia syndrome in its early stages
Keping Chen, Huidi Sun, Yu Geng, Chuankun Yang, Chun Shan, Yuxin Chen
Frontiers in Microbiology.2023;[Epub] CrossRef
Evaluation of Serum Ferritin, Procalcitonin, and C-Reactive Protein for the Prediction of Severity and Mortality in Hemorrhagic Fever With Renal Syndrome
Lihe Che, Zedong Wang, Na Du, Liang Li, Yinghua Zhao, Kaiyu Zhang, Quan Liu
Frontiers in Microbiology.2022;[Epub] CrossRef
Hepatocellular adenomas: recent updates
Haeryoung Kim, Young Nyun Park
Journal of Pathology and Translational Medicine.2021; 55(3): 171. CrossRef
A prospective follow-up study of the relationship between high-sensitivity C-reactive protein and primary liver cancer
Sarah Tan Siyin, Tong Liu, Wenqiang Li, Nan Yao, Guoshuai Xu, Jun Qu, Yajun Chen
BMC Cancer.2020;[Epub] CrossRef
CRP Levels in Viral Hepatitis: A Meta-Analysis Study
Sukhpal Singh, Abhishek Bansal, Pardeep Kumar
International Journal of Infection.2020;[Epub] CrossRef

Characteristic Changes in Decidual Gene Expression Signature in Spontaneous Term Parturition: Haidy El-Azzamy, Andrea Balogh, Roberto Romero, Yi Xu, Christopher LaJeunesse, Olesya Plazyo, Zhonghui Xu, Theodore G. Price, Zhong Dong, Adi L. Tarca, Zoltan Papp, Sonia S. Hassan, Tinnakorn Chaiworapongsa, Chong Jai Kim, Nardhy Gomez-Lopez, Nandor Gabor Than; J Pathol Transl Med. 2017;51(3):264-283. Published online February 22, 2017; DOI: https://doi.org/10.4132/jptm.2016.12.20

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Abstract PDF Supplementary Material

Background
The decidua has been implicated in the “terminal pathway” of human term parturition, which is characterized by the activation of pro-inflammatory pathways in gestational tissues. However, the transcriptomic changes in the decidua leading to terminal pathway activation have not been systematically explored. This study aimed to compare the decidual expression of developmental signaling and inflammation-related genes before and after spontaneous term labor in order to reveal their involvement in this process.
Methods
Chorioamniotic membranes were obtained from normal pregnant women who delivered at term with spontaneous labor (TIL, n = 14) or without labor (TNL, n = 15). Decidual cells were isolated from snap-frozen chorioamniotic membranes with laser microdissection. The expression of 46 genes involved in decidual development, sex steroid and prostaglandin signaling, as well as pro- and anti-inflammatory pathways, was analyzed using high-throughput quantitative real-time polymerase chain reaction (qRT-PCR). Chorioamniotic membrane sections were immunostained and then semi-quantified for five proteins, and immunoassays for three chemokines were performed on maternal plasma samples.
Results
The genes with the highest expression in the decidua at term gestation included insulin-like growth factor-binding protein 1 (IGFBP1), galectin-1 (LGALS1), and progestogen-associated endometrial protein (PAEP); the expression of estrogen receptor 1 (ESR1), homeobox A11 (HOXA11), interleukin 1β (IL1B), IL8, progesterone receptor membrane component 2 (PGRMC2), and prostaglandin E synthase (PTGES) was higher in TIL than in TNL cases; the expression of chemokine C-C motif ligand 2 (CCL2), CCL5, LGALS1, LGALS3, and PAEP was lower in TIL than in TNL cases; immunostaining confirmed qRT-PCR data for IL-8, CCL2, galectin-1, galectin-3, and PAEP; and no correlations between the decidual gene expression and the maternal plasma protein concentrations of CCL2, CCL5, and IL-8 were found.
Conclusions
Our data suggests that with the initiation of parturition, the decidual expression of anti-inflammatory mediators decreases, while the expression of pro-inflammatory mediators and steroid receptors increases. This shift may affect downstream signaling pathways that can lead to parturition.

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The sweet and the bitter sides of galectin-1 in immunity: its role in immune cell functions, apoptosis, and immunotherapies for cancer with a focus on T cells
Julianna Novák, Tamás Takács, Álmos Tilajka, Loretta László, Orsolya Oravecz, Emese Farkas, Nándor Gábor Than, László Buday, Andrea Balogh, Virág Vas
Seminars in Immunopathology.2025;[Epub] CrossRef
Progesterone inactivation in decidual stromal cells: A mechanism for inflammation-induced parturition
Angela DeTomaso, Hyeyon Kim, Jacqueline Shauh, Anika Adulla, Sarah Zigo, Maya Ghoul, Pietro Presicce, Suhas G. Kallapur, Wendy Goodman, Tamara Tilburgs, Sing-Sing Way, David Hackney, John Moore, Sam Mesiano
Proceedings of the National Academy of Sciences.2024;[Epub] CrossRef
The endoplasmic reticulum protein HSPA5/BiP is essential for decidual transformation of human endometrial stromal cells
Laura Fernández, Chow-Seng Kong, Majd Alkhoury, Maria Tryfonos, Paul J. Brighton, Thomas M. Rawlings, Joanne Muter, Maria Soledad Gori, Claudia Pérez Leirós, Emma S. Lucas, Jan J. Brosens, Rosanna Ramhorst
Scientific Reports.2024;[Epub] CrossRef
Galectin‐1 Elicits a Tissue‐Specific Anti‐Inflammatory and Anti‐Degradative Effect Upon LPS‐Induced Response in an Ex Vivo Model of Human Fetal Membranes Modeling an Intraamniotic Inflammation
Jazmin Hernández‐Rodríguez, Jesús Pérez‐Hernández, Pilar Flores‐Espinosa, Andrea Olmos‐Ortiz, Pilar Velazquez, Rodrigo Zamora‐Escudero, Marcela Islas‐López, Addy Cecilia Helguera‐Repetto, Karla Hernández‐Bones, Samara Rodríguez‐Flores, Rodrigo Jiménez‐Esc
American Journal of Reproductive Immunology.2024;[Epub] CrossRef
Is human labor at term an inflammatory condition?
Chandrashekara Kyathanahalli, Madeline Snedden, Emmet Hirsch
Biology of Reproduction.2023; 108(1): 23. CrossRef
CCL2: An important cytokine in normal and pathological pregnancies: A review
Zhi Lin, Jia-Lu Shi, Min Chen, Zi-Meng Zheng, Ming-Qing Li, Jun Shao
Frontiers in Immunology.2023;[Epub] CrossRef
Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death
Dahiana M. Gallo, Wendy Fitzgerald, Roberto Romero, Nardhy Gomez-Lopez, Dereje W. Gudicha, Nándor Gábor Than, Mariachiara Bosco, Tinnakorn Chaiworapongsa, Eunjung Jung, Arun Meyyazhagan, Manaphat Suksai, Francesca Gotsch, Offer Erez, Adi L. Tarca, Leonid
The Journal of Maternal-Fetal & Neonatal Medicine.2023;[Epub] CrossRef
Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway
Hui Zhang, Zhilong Wang, Quan Zhou, Zhiwen Cao, Yue Jiang, Manlin Xu, Jingyu Liu, Jidong Zhou, Guijun Yan, Haixiang Sun
Journal of Assisted Reproduction and Genetics.2023; 40(5): 1135. CrossRef
Regulation of inflammatory genes in decidual cells: Involvement of the bromodomain and extra-terminal family proteins
Sandeep Ajgaonkar, Jonathan J. Hirst, Mary Norris, Tamas Zakar, Giovanni Camussi
PLOS ONE.2023; 18(3): e0280645. CrossRef
Decidual cells and decidualization in the carnivoran endotheliochorial placenta
Mónica Elizabeth Diessler, Rocío Hernández, Gimena Gomez Castro, Claudio Gustavo Barbeito
Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef
Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System
Priya Prasad, Roberto Romero, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Anderson Lo, Jose Galaz, Andreea B. Taran, Eunjung Jung, Francesca Gotsch, Nandor Gabor Than, Adi L. Tarca
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Galectins-1, -3 and -9 Are Present in Breast Milk and Have a Role in Early Life Development
Karla Rio-Aige, Marina Girbal, Marta Selma-Royo, Anna Parra-Llorca, Sonia González, Cecilia Martínez-Costa, Margarida Castell, María Carmen Collado, Francisco J. Pérez-Cano, María J. Rodríguez-Lagunas
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The Expression of IL-1β Correlates with the Expression of Galectin-3 in the Tissue at the Maternal–Fetal Interface during the Term and Preterm Labor
Nikola Jovic, Marija Milovanovic, Jovana Joksimovic Jovic, Marija Bicanin Ilic, Dejana Rakic, Vladimir Milenkovic, Bojana Stojanovic, Jelena Milovanovic, Aleksandar Arsenijevic, Nebojsa Arsenijevic, Mirjana Varjacic
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Galectin-1 and Galectin-9 Concentration in Maternal Serum: Implications in Pregnancies Complicated with Preterm Prelabor Rupture of Membranes
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Placental galectins regulate innate and adaptive immune responses in pregnancy
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The Role of Decidual Subpopulations in Implantation, Menstruation and Miscarriage
Joanne Muter, Chow-Seng Kong, Jan J. Brosens
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Multiomic immune clockworks of pregnancy
Laura S. Peterson, Ina A. Stelzer, Amy S. Tsai, Mohammad S. Ghaemi, Xiaoyuan Han, Kazuo Ando, Virginia D. Winn, Nadine R. Martinez, Kevin Contrepois, Mira N. Moufarrej, Stephen Quake, David A. Relman, Michael P. Snyder, Gary M. Shaw, David K. Stevenson, R
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Sandra M. Blois, Stefan Verlohren, Gang Wu, Gary Clark, Anne Dell, Stuart M. Haslam, Gabriela Barrientos
Seminars in Immunopathology.2020; 42(4): 469. CrossRef
Functional changes in decidual mesenchymal stem/stromal cells are associated with spontaneous onset of labour
Joan C Wijaya, Ramin Khanabdali, Harry M Georgiou, Maria I Kokkinos, Patrick F James, Shaun P Brennecke, Bill Kalionis
Molecular Human Reproduction.2020; 26(8): 636. CrossRef
Ageing in human parturition: impetus of the gestation clock in the decidua†
Joan C Wijaya, Ramin Khanabdali, Harry M Georgiou, Bill Kalionis
Biology of Reproduction.2020; 103(4): 695. CrossRef
Cytotrophoblast extracellular vesicles enhance decidual cell secretion of immune modulators via TNF-alpha
Sara K. Taylor, Sahar Houshdaran, Joshua F. Robinson, Matthew J. Gormley, Elaine Y. Kwan, Mirhan Kapidzic, Birgit Schilling, Linda C. Giudice, Susan J. Fisher
Development.2020;[Epub] CrossRef
A trypsin-based method for isolating leukocytes from human choriodecidua suitable for immunophenotyping and transcriptome studies
Karla MacDonald-Ramos, Marcia Arenas-Hernandez, Ismael Mancilla-Herrera, Claudia Rangel-Escareño, Rodrigo Vega-Sanchez
Immunobiology.2019; 224(1): 177. CrossRef
Transcriptomic analysis of fetal membranes reveals pathways involved in preterm birth
Silvana Pereyra, Claudio Sosa, Bernardo Bertoni, Rossana Sapiro
BMC Medical Genomics.2019;[Epub] CrossRef
Placental Galectins Are Key Players in Regulating the Maternal Adaptive Immune Response
Andrea Balogh, Eszter Toth, Roberto Romero, Katalin Parej, Diana Csala, Nikolett L. Szenasi, Istvan Hajdu, Kata Juhasz, Arpad F. Kovacs, Hamutal Meiri, Petronella Hupuczi, Adi L. Tarca, Sonia S. Hassan, Offer Erez, Peter Zavodszky, Janos Matko, Zoltan Pap
Frontiers in Immunology.2019;[Epub] CrossRef
Amnion epithelial cell–derived exosomes induce inflammatory changes in uterine cells
Emily E. Hadley, Samantha Sheller-Miller, George Saade, Carlos Salomon, Sam Mesiano, Robert N. Taylor, Brandie D. Taylor, Ramkumar Menon
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Selective immuno-modulatory effect of prolactin upon pro-inflammatory response in human fetal membranes
Pilar Flores-Espinosa, Eduardo Preciado-Martínez, Araceli Mejía-Salvador, Gabriela Sedano-González, Luisa Bermejo-Martínez, Adalberto Parra-Covarruvias, Guadalupe Estrada-Gutiérrez, Rodrigo Vega-Sánchez, Isabel Méndez, Braulio Quesada-Reyna, Andrea Olmos-
Journal of Reproductive Immunology.2017; 123: 58. CrossRef

Diagnostic Significance of Cellular Neuroglial Tissue in Ovarian Immature Teratoma: Yun Chai, Chang Gok Woo, Joo-Young Kim, Chong Jai Kim, Shin Kwang Khang, Jiyoon Kim, In Ah Park, Eun Na Kim, Kyu-Rae Kim; J Pathol Transl Med. 2017;51(1):49-55. Published online October 14, 2016; DOI: https://doi.org/10.4132/jptm.2016.09.19

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Abstract PDF

Background
Immature teratoma (IT) is a tumor containing immature neuroectodermal tissue, primarily in the form of neuroepithelial tubules. However, the diagnosis of tumors containing only cellular neuroglial tissue (CNT) without distinct neuroepithelial tubules is often difficult, since the histological characteristics of immature neuroectodermal tissues remain unclear. Here, we examined the significance of CNT and tried to define immature neuroectodermal tissues by comparing the histological features of neuroglial tissues between mature teratoma (MT) and IT.
Methods
The histological features of neuroglial tissue, including the cellularity, border between the neuroglial and adjacent tissues, cellular composition, mitotic index, Ki-67 proliferation rate, presence or absence of tissue necrosis, vascularity, and endothelial hyperplasia, were compared between 91 MT and 35 IT cases.
Results
CNTs with a cellularity grade of ≥ 2 were observed in 96% of IT cases and 4% of MT cases (p < .001); however, CNT with a cellularity grade of 3 in MT cases was confined to the histologically distinct granular layer of mature cerebellar tissue. Moreover, CNT in IT exhibited significantly higher rates of Ki-67 proliferation, mitoses, and necrosis than those in MT (p < .001). Furthermore, an infiltrative border of neuroglial tissue and glomeruloid endothelial hyperplasia were significantly more frequent in IT cases than in MT cases (p < .001).
Conclusions
Our results suggest that if CNT with a cellularity grade of ≥ 2 is not a component of cerebellar tissue, such cases should be diagnosed as IT containing immature neuroectodermal tissue, particularly if they exhibit an infiltrative border, mitoses, necrosis, and increased Ki-67 proliferation.

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History of the Official Journal Published by the Korean Society of Pathologists: From the Korean Journal of Pathology to the Journal of Pathology and Translational Medicine: Se Hoon Kim, Chong Jai Kim, SoonWon Hong; J Pathol Transl Med. 2017;51(1):1-6. Published online January 13, 2017; DOI: https://doi.org/10.4132/jptm.2017.01.07

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In Memory of Professor Je Geun Chi, a Great Mentor and Pathologist: Chong Jai Kim; J Pathol Transl Med. 2015;49(6):425-426. Published online November 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.10.06

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Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia: Nandor Gabor Than, Roberto Romero, Andrea Balogh, Eva Karpati, Salvatore Andrea Mastrolia, Orna Staretz-Chacham, Sinuhe Hahn, Offer Erez, Zoltan Papp, Chong Jai Kim; J Pathol Transl Med. 2015;49(3):181-208. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.02.25

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Abstract PDF

Galectins are an evolutionarily ancient and widely expressed family of lectins that have unique glycan-binding characteristics. They are pleiotropic regulators of key biological processes, such as cell growth, proliferation, differentiation, apoptosis, signal transduction, and pre-mRNA splicing, as well as homo- and heterotypic cell-cell and cell-extracellular matrix interactions. Galectins are also pivotal in immune responses since they regulate host-pathogen interactions, innate and adaptive immune responses, acute and chronic inflammation, and immune tolerance. Some galectins are also central to the regulation of angiogenesis, cell migration and invasion. Expression and functional data provide convincing evidence that, due to these functions, galectins play key roles in shared and unique pathways of normal embryonic and placental development as well as oncodevelopmental processes in tumorigenesis. Therefore, galectins may sometimes act as double-edged swords since they have beneficial but also harmful effects for the organism. Recent advances facilitate the use of galectins as biomarkers in obstetrical syndromes and in various malignancies, and their therapeutic applications are also under investigation. This review provides a general overview of galectins and a focused review of this lectin subfamily in the context of inflammation, infection and tumors of the female reproductive tract as well as in normal pregnancies and those complicated by the great obstetrical syndromes.

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Overexpression of C-reactive Protein as a Poor Prognostic Marker of Resectable Hepatocellular Carcinomas: Jin Ho Shin, Chong Jai Kim, Eun Jeong Jeon, Chang Ohk Sung, Hwa Jeong Shin, Jene Choi, Eunsil Yu; J Pathol Transl Med. 2015;49(2):105-111. Published online March 12, 2015; DOI: https://doi.org/10.4132/jptm.2015.01.19

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Abstract PDF

Background
C-reactive protein (CRP) is an acute phase reactant synthesized in the liver. CRP immunoreactivity is a feature of inflammatory hepatocellular adenomas with a higher risk of malignant transformation. A high serum CRP level denotes poor prognosis in hepatocellular carcinoma (HCC) patients. This study was conducted to determine whether CRP is produced in HCC and to assess the clinicopathologic significance of CRP expression in cancer cells. Methods: CRP immunoreactivity was examined in treatment-naïve HCCs (n=224) using tissue microarrays and was correlated with clinicopathologic parameters. The expression of CRP mRNA and protein was also assessed in 12 HCC cases by quantitative real-time polymerase chain reaction and immunoblotting. Hep3B and SNU-449 HCC cell lines were used for the analysis of CRP mRNA regulation by interleukin 6 (IL-6). Results: CRP was expressed in 133 of 224 HCCs (59.4%) with a variable degree of immunoreactivity (grade 1 in 25.9%; grade 2 in 20.1%; grade 3 in 13.4%). There was an inverse relationship between grade 3 CRP immunoreactivity and cancer-specific survival (p=.0047), while no associations were found with other parameters, including recurrence-free survival. The CRP mRNA expression level was significantly higher in CRP immunopositive cases than in immunonegative cases (p<.05). CRP mRNA expression was increased in Hep3B cells, but was not detected in SNU-449 cells even after IL-6 treatment. Conclusions: We report the expression of CRP in HCC for the first time. CRP expression was associated with poor cancer-specific survival in patients with resectable HCC.

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