- Statistical analysis and histopathological study on hepatic diseases among Koreans
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Chung Hee Chi
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Korean J Cytopathol. 1971;5(2):143-147.
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- Total 337 cases too liver biopsy specimens and 98 autopsy cases of hepatic diseases obtained at the National Medical Center during the period of 1958 to 1968 were histopathologically examined with statistical analysis for international classification of diseases and correlation between clinical diagnosis and histopathological diagnosis was made.
As the result of present study the following conclusions were obtained.
1) By sex, number of male is dominant than female in both biopsy 229 cases (male), 108 cases (Female) 2.1 : 1, and autopsy cases 72(%ale), 26(Female) 2.8 : 1.
2) Among the groups of hepatic lesions cirrhosis is 80.5% (M 4l. 6%, F 38.9%) with highest incidence in biopsy material and average age is 34.5 years. Identical findings are seen in autopsy cases with 57 cases (M 40, F 17) out of 98 cases with the range of 55.6% (M) and 65.4% (F).
3) Post hepatitic cirrhosis is highest among the cirrhotic groups of biopsy material with 88 cases (M 66, F 22) out of total cirrhosis cases of 137(M 95, F 42) and portal 22 cases (15 M, 7 F), post necrotic 15 cases (9 M, 6 F), biliary 7 cases (4 M,3 F) as in decreasing order with exceptional 1 case of nutritional Cirrhosis.
4) Average age of tumor is 44. 1 years and somewhat higher than that of cirrhosis 34. 5 years. Tumors among the biopsy material revealed highest incidence of hepatoma 61 cases, extra bile duct ca. 66 cases, and cholangioma 8 cases in decreasing order.
5) In autopsy material age distribution and frequency of hepatic diseases were mostly similar to that of the biopsy material, however, abscesses were comparatively higher in
cadaver material. Post hepatitic cirrhosis was 36 cases out of 137 cases and 16 cases of post necrotic cirrhosis was next to the highest incidence.
6) Analytic pilot study for various histopathologic findings to evaluate the grouping of the hepatic lesions (biopsy) without knowing of previous clinico-pathologic diagnosis or laboratory findings showed no remarkable or significant difference among the disease groups.
7) Correlation between clinical and pathologic diagnosis showed considerable percentage of difference. The difference in abscess and hepatitis was only 9.1%.
- A Histopathological Study on Primary Malignant Bone Tumors
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Choon Won Kim, Shin Eun Choi, Chung Hee Chi
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Korean J Cytopathol. 1970;4(1):1-12.
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- A histopathological study was made on 53 cases of primary malignant bone tumors of the Koreans, obtained during a period of 11 years 10 months, from January 1959 to October 1970, at the Department of Pathology, National Medical Center, Seoul, Korea
1. The 53 cases of primary malignant bone tumors consist of 36 cases(67.9%) in male and 17 cases(32.1%) in female. The sex ratio of male and female was 2.1 : 1.
2. The youngest age was 2 years old and the oldest was 68 years old.
3. The 20 cases (37.8%) of 53 cases were 10∼19 years old in age group and the highest incidence, but 60∼69 years age group were only 2 cases (3.6%).
4. The 11 cases (30.6%) of 36 cases of male and 9 cases (53%) of 17 cases of female were 10∼19 years age group.
5. Osteogenic sarcoma was 21 cases (39.6%) of all malignant bone tumors. The sex ratio of male and female was 61.9% : 38.1% and the highest age incidence was 10∼19 years old group (52%).
6. Chondrosarcoma was 5 cases (9.1%) and observed in the all male.
7. Ewing’s sarcoma was 6 cases (10.7%).
8. Fibrosarcoma was 4 cases(7.2%).
9. Giant cell tumor was 2 cases (3.6%).
10. Multiple myeloma was 7 cases including 2 autopsy cases (13.2%). Male was 6 cases (85.7%), female was only 1 cases (14.3%) and its average age was 48.1 years old.
11. Malignant mesenchymal tumor was 6 cases (10.7%)
12. The most frequent site of the all malignant bone tumor was observed in femur (26.1%), in tibia (17%) and in fibula (13.2%).
13. The 53 cases of primary malignant bone tumors were histopathologically classified and tabulated.
- The interaction of radiation marrow damage on the erythroleukemia virus activity
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Chung Hee Chi, B. Lagerlof
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Korean J Cytopathol. 1968;2(1):25-30.
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- X-線 照射로 生後 1日된 영계(병아리)에 骨髓障碍를 일으켰을 侍 赤血球性 白血症 virus가 骨髓에 미치는 活性에 대한 相互關係를 實驗的으로 考察하였다. 一群을 C0 60 600r를 照射했으며 4, 8, 20日 後에 各各 赤血球性 白血症 virus를 靜脈內 注射하였다.
注射前 處置로는 各各 大腿骨에서 骨髓의 生檢을 施行하였음.
豫備試驗의 結果 全身 X-線 照射에 의한 骨髓의 障碍는 고루 미치는 것을 周池하였으므로 전 骨髓의 代表的 部位로서 大腿骨을 選定하였다.
對照群으로서 使用한 것은 X-線 照射를 하지 않았으며 同一하게 骨髓의 生檢을 4, 8, 20일 후에 施行하고 각각 virus를 接種하였다.
白血症의 發生率과 實驗動物이 死亡하게 될 때까지의 潛伏期間은 照射群과 對照群 兩者에서 大同小異하였다. virus 接種의 時期에 關係없이 X-線 照射로 인한 骨髓障碍의 程度에 따라 動物群을 分類해 본 結果 激甚한 X-線 骨髓障碍와 細胞減少症(Hypocellularity)을 主로 하는 動物群은 virus 病原性 活性을 抑制함을 提示했으나 한편 中等屠의 障碍를 가진 動物群에서 오히려 virus의 活性度를 加重시켰다. 組織學的으로 赤血球의 再生力에 따라 分類해본 結果 活潑한 赤血球 造血機能을 가진 動物群은 X-線 照射하지 않은 對照群과 同一한 virus의 活性을 나타냈으나 赤血球 造血機能의 證據가 없는 動物群에서는 virus에 대한 感受性은 極히 低下돼있었다.
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