Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine


Author index

Page Path
HOME > Articles and issues > Author index
Dong-Sik Kim 5 Articles
Combined Adenosquamous and Large Cell Neuroendocrine Carcinoma of the Gallbladder
Jiyoon Jung, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Dong-Sik Kim, Young-Dong Yu, Joo Young Kim
J Pathol Transl Med. 2018;52(2):121-125.   Published online October 5, 2017
  • 5,942 View
  • 134 Download
  • 6 Citations
AbstractAbstract PDF
Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3×4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed. LCNEC showed round cells with large, vesicular nuclei, abundant mitotic figures, and occasional pseudorosette formation. The patient received adjuvant chemotherapy. However, multiple liver metastases were identified at 3-month follow-up. Metastatic nodules were composed of LCNEC and squamous cell carcinoma components. Detecting LCNEC component is important in gallbladder cancer, because the tumor may require a different chemotherapy regimen and show early metastasis and poor prognosis.


Citations to this article as recorded by  
  • Comparison of Metastatic Patterns Among Neuroendocrine Tumors, Neuroendocrine Carcinomas, and Nonneuroendocrine Carcinomas of Various Primary Organs
    Hyung Kyu Park, Ghee Young Kwon
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Primary mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: A case report and literature review
    Tingting Yu, Shike Li, Zhuo Zhang
    Asian Journal of Surgery.2022; 45(11): 2336.     CrossRef
  • Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder: case report and literature review
    Xu Ren, Hong Jiang, Kan Sun, Xufu Qin, Yongping Qu, Tian Xia, Yan Chen
    Diagnostic Pathology.2022;[Epub]     CrossRef
  • Neuroendocrine Neoplasms of the Gallbladder: A Clinicopathological Analysis of 13 Patients and a Review of the Literature
    Pengyan Wang, Jingci Chen, Ying Jiang, Congwei Jia, Junyi Pang, Shan Wang, Xiaoyan Chang, Oronzo Brunetti
    Gastroenterology Research and Practice.2021; 2021: 1.     CrossRef
  • Gallbladder Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Arising in Intracholecystic Papillary Neoplasm: Clinicopathologic and Molecular Analysis of a Case and Review of the Literature
    Amedeo Sciarra, Edoardo Missiaglia, Mounir Trimech, Emmanuel Melloul, Jean-Philippe Brouland, Christine Sempoux, Stefano La Rosa
    Endocrine Pathology.2020; 31(1): 84.     CrossRef
  • Mixed neuroendocrine-non-neuroendocrine carcinoma of gallbladder: case report
    Adam Skalický, Lucie Vištejnová, Magdaléna Dubová, Tomáš Malkus, Tomáš Skalický, Ondřej Troup
    World Journal of Surgical Oncology.2019;[Epub]     CrossRef
Hyalinizing Cholecystitis and Associated Carcinoma: A Case Report
Youngjin Kang, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Dong-Sik Kim, Young-Dong Yu, Joo Young Kim
J Pathol Transl Med. 2018;52(1):64-66.   Published online April 4, 2017
  • 7,662 View
  • 188 Download
  • 4 Citations


Citations to this article as recorded by  
  • 18F-FDG PET/CT in Hyalinized Cholecystitis
    Esra Arslan, Aytül Hande Yardimci, Enver Yarikkaya, Göksel Alçin, Tevfik Fikret Çermik
    Clinical Nuclear Medicine.2021; 46(4): e228.     CrossRef
  • Gallbladder Carcinoma and Its Differential Diagnosis at MRI: What Radiologists Should Know
    Camila Lopes Vendrami, Michael J. Magnetta, Pardeep K. Mittal, Courtney C. Moreno, Frank H. Miller
    RadioGraphics.2021; 41(1): 78.     CrossRef
  • A simple method for diagnosing gallbladder malignant tumors with subserosa invasion by endoscopic ultrasonography
    Mitsuru Sugimoto, Hiroki Irie, Mika Takasumi, Minami Hashimoto, Yuka Oka, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Tsunetaka Kato, Ryoichiro Kobashi, Yuko Hashimoto, Shigeru Marubashi, Takuto Hikichi, Hiromasa Ohi
    BMC Cancer.2021;[Epub]     CrossRef
    Leymune PARLAK, Bahar MEMİŞ
    Balıkesir Medical Journal.2019; 3(3): 129.     CrossRef
Notice of Retraction: Therapeutic Effects of Umbilical Cord Blood Derived Mesenchymal Stem Cell-Conditioned Medium on Pulmonary Arterial Hypertension in Rats
Jae Chul Lee, Choong Ik Cha, Dong-Sik Kim, Soo Young Choe
J Pathol Transl Med. 2016;50(4):325-325.   Published online July 15, 2016
Retracts: J Pathol Transl Med 2015;49(6):472
  • 6,649 View
  • 90 Download
  • 1 Citations


Citations to this article as recorded by  
  • Blockade of Neuroglobin Reduces Protection of Conditioned Medium from Human Mesenchymal Stem Cells in Human Astrocyte Model (T98G) Under a Scratch Assay
    Eliana Baez-Jurado, Gina Guio Vega, Gjumrakch Aliev, Vadim V. Tarasov, Paula Esquinas, Valentina Echeverria, George E. Barreto
    Molecular Neurobiology.2018; 55(3): 2285.     CrossRef
Therapeutic Effects of Umbilical Cord Blood Derived Mesenchymal Stem Cell-Conditioned Medium on Pulmonary Arterial Hypertension in Rats
Jae Chul Lee, Choong Ik Cha, Dong-Sik Kim, Soo Young Choe
J Pathol Transl Med. 2015;49(6):472-480.   Published online October 16, 2015
Retraction in: J Pathol Transl Med 2016;50(4):325
  • 12,812 View
  • 65 Download
  • 7 Citations
Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases
Hyunchul Kim, Ja-June Jang, Dong-Sik Kim, Beom Woo Yeom, Nam Hee Won
Korean J Pathol. 2013;47(5):411-417.   Published online October 25, 2013
  • 7,242 View
  • 37 Download
  • 6 Citations
AbstractAbstract PDF

Hepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1α [HNF1α]-mutated, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has recently been established based on a single institutional review of a HCA series by the Bordeaux group.


We used histologic and immunohistochemical parameters to classify and evaluate eight cases from our institution. We evaluated the new classification method and analyzed correlations between our results and those of other reports.


Seven of our eight cases showed histologic and immunohistochemical results consistent with previous reports. However, one case showed overlapping histologic features, as previously described by the Bordeaux group. Four cases showed glutamine synthetase immunohistochemical staining inconsistent with their classification, indicating that glutamine synthetase staining may not be diagnostic for β-catenin-mutated HCA. HNF1α-mutated HCA may be indicated by the absence of liver fatty acid binding protein expression. Detection of amyloid A may indicate inflammatory HCA. HCA with no mutation in the HNF1α or β-catenin genes and no inflammatory protein expression is categorized as unclassified HCA.


Although the new classification is now generally accepted, validation through follow-up studies is necessary.


Citations to this article as recorded by  
  • Relevance of morphological features for hepatocellular adenoma classification in pathology practice
    Carla Henriques Agostini, Osmar Damasceno Ribeiro, Arlete Fernandes, Adriana Caroli-Bottino, Vera Lucia Pannain
    Surgical and Experimental Pathology.2020;[Epub]     CrossRef
  • The molecular functions of hepatocyte nuclear factors – In and beyond the liver
    Hwee Hui Lau, Natasha Hui Jin Ng, Larry Sai Weng Loo, Joanita Binte Jasmen, Adrian Kee Keong Teo
    Journal of Hepatology.2018; 68(5): 1033.     CrossRef
  • Hepatocellular adenoma: Classification, variants and clinical relevance
    Paulette Bioulac-Sage, Christine Sempoux, Charles Balabaud
    Seminars in Diagnostic Pathology.2017; 34(2): 112.     CrossRef
  • A Limited Immunohistochemical Panel Can Subtype Hepatocellular Adenomas for Routine Practice
    Brent K. Larson, Maha Guindi
    American Journal of Clinical Pathology.2017; 147(6): 557.     CrossRef
  • Hepatocellular Neoplasms Arising in Association With Androgen Use
    Sounak Gupta, Bita V. Naini, Richard Munoz, Rondell P. Graham, Benjamin R. Kipp, Michael S. Torbenson, Taofic Mounajjed
    American Journal of Surgical Pathology.2016; 40(4): 454.     CrossRef
  • Pigmented hepatocellular adenomas have a high risk of atypia and malignancy
    Taofic Mounajjed, Saba Yasir, Patrice A Aleff, Michael S Torbenson
    Modern Pathology.2015; 28(9): 1265.     CrossRef

JPTM : Journal of Pathology and Translational Medicine