- Cytopathologic features of human papillomavirus–independent, gastric-type endocervical adenocarcinoma
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Min-Kyung Yeo, Go Eun Bae, Dong-Hyun Kim, In-Ock Seong, Kwang-Sun Suh
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J Pathol Transl Med. 2022;56(5):260-269. Published online September 13, 2022
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DOI: https://doi.org/10.4132/jptm.2022.07.05
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- Background
Gastric-type endocervical adenocarcinoma (GEA) is unrelated to human papillomavirus (HPV) infection and is clinically aggressive compared with HPV-associated usual-type endocervical adenocarcinoma (UEA). The cytological diagnosis falls short of a definitive diagnosis of GEA and is often categorized as atypical glandular cells (AGCs). To improve cytologic recognition, cytological findings of HPV-independent GEA were analyzed and the results compared with HPV-associated UEA.
Methods Cervical Papanicolaou (Pap) smears from eight patients with a histopathologic diagnosis of GEA and 12 control cases of UEA were reviewed. All slides were conventionally prepared and/or liquid-based prepared (ThinPrep) and stained following the Pap method. A mucinous background, architectural, nuclear, and cytoplasmic features were analyzed and compared with UEA.
Results Preoperative cytologic diagnoses of the eight GEA cases were AGCs, favor neoplastic in three cases, adenocarcinoma in situ in one case, and adenocarcinoma in four cases. Cytologically, monolayered honeycomb-like sheets (p = .002) of atypical endocervical cells with vacuolar granular cytoplasm (p = .001) were extensive in GEA, and three-dimensional clusters (p = .010) were extensive in UEA. Although the differences were not statistically significant, background mucin (p = .058), vesicular nuclei (p = .057), and golden-brown intracytoplasmic mucin (p = .089) were also discriminatory findings for GEA versus UEA.
Conclusions Although GEA is difficult to diagnose on cytologic screening, GEA can be recognized based on cytologic features of monolayered honeycomb sheets of atypical endocervical cells with abundant vacuolar cytoplasm and some golden-brown intracytoplasmic mucin. UEA cases are characterized by three-dimensional clusters.
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- Risk Factors Affecting Clinical Outcomes of Low-risk Early-stage Human Papillomavirus–Associated Endocervical Adenocarcinoma Treated by Surgery Alone: Application of Silva Pattern
Bong Kyung Bae, Hyunsik Bae, Won Kyung Cho, Byoung-Gie Kim, Chel Hun Choi, Tae-Joong Kim, Yoo-Young Lee, Jeong-Won Lee, Hyun-Soo Kim, Won Park International Journal of Gynecological Pathology.2024; 43(5): 447. CrossRef - Tall‐columnar glandular cells in SurePath™ liquid‐based cytology Pap sample: Learning from mimics/pitfalls
Nalini Gupta, Vanita Jain, Radhika Srinivasan, Tulika Singh Cytopathology.2024; 35(4): 510. CrossRef
- Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy
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Kwang-Sun Suh, Song-Yi Choi, Go Eun Bae, Dae Eun Choi, Min-kyung Yeo
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J Pathol Transl Med. 2019;53(6):399-402. Published online September 16, 2019
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DOI: https://doi.org/10.4132/jptm.2019.08.05
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PDF Supplementary Material
- Anti–glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of IgG along the GBM. In a limited number of cases, glomerular immune complexes have been identified in anti-GBM nephritis. A 38-year-old female presented azotemia, hematuria, and proteinuria without any pulmonary symptoms. A renal biopsy showed crescentic GN with linear IgG deposition along the GBM and mesangial IgA deposition. The patient was diagnosed as concurrent anti-GBM nephritis and IgA nephropathy. Therapies with pulse methylprednisolone and cyclophosphamide administration were effective. Concurrent cases of both anti-GBM nephritis and IgA nephropathy are rare among cases of anti-GBM diseases with deposition of immune complexes. This rare case of concurrent anti-GBM nephritis and IgA nephropathy with literature review is noteworthy.
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Li Gao, Xuan Zhang, Dongrong Yu, Hong Zhu, Qin Zhu International Urology and Nephrology.2025;[Epub] CrossRef - Coexistence of anti-glomerular basement membrane disease and IgA nephropathy: an illustrative case and comprehensive literature review
Zewei Chen, Dechao Xu, Fangzheng Cui, Huihui Hou, Zhiguo Mao, Xiang Gao Renal Failure.2024;[Epub] CrossRef - Clinical features and prognosis of patients with anti-GBM disease combined with mesangial IgA deposition
Wei Ning, Ya-fei Zhao, Ya-ru Liu, Yuan-yuan Qi, Zhan-zheng Zhao Frontiers in Immunology.2024;[Epub] CrossRef - A Case of Concurrent Anti-Glomerular Basement Membrane Antibody Disease and Immunoglobulin A Nephropathy
Su In Kim, Sung Sun Kim, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Hong Sang Choi The Korean Journal of Medicine.2024; 99(6): 322. CrossRef - Anti-glomerular basement membrane vasculitis
Claudio Ponticelli, Marta Calatroni, Gabriella Moroni Autoimmunity Reviews.2023; 22(1): 103212. CrossRef - High-frequency plasma exchange therapy for immunocompromised, type I crescentic glomerulonephritis complicated with IgA nephropathy: A case report and literature review
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Cong-rong Shen, Xiao-yu Jia, Zhao Cui, Xiao-juan Yu, Ming-hui Zhao Clinical Kidney Journal.2023; 16(9): 1480. CrossRef - Anti-glomerular basement membrane disease with IgA nephropathy: A case report
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Wei Qu, Nan Liu, Tianhua Xu, Binyao Tian, Meng Wang, Yanqiu Li, Jianfei Ma, Li Yao Frontiers in Pharmacology.2022;[Epub] CrossRef - Great prognosis of concurrent anti-GBM disease and IgA nephropathy in a young woman: A case report
Fu Shaojie, Su Sensen, Huang Jingda, Wang Luyu, Zhang Fei, Yu Jinyu, Xu Zhonggao, Wu Hao Medicine.2022; 101(37): e30686. CrossRef - Serodiagnosis of Anti-glomerular Basement Membrane Disease Using a Newly Developed Chemiluminescence Immunoassay
Alexander Kühnl, Lea Hartwig, Cornelia Dähnrich, Wolfgang Schlumberger Frontiers in Medicine.2022;[Epub] CrossRef - PATHOLOGY AND RENAL OUTCOME OF THREE UNCOMMON FACES OF CRESCENTRIC GLOMERULONEPHRITIS
Keya Basu, Dipankar Sircar, Manimoy Bandopadhyay INDIAN JOURNAL OF APPLIED RESEARCH.2021; : 7. CrossRef - Pneumocystis pneumonia secondary to intensive immunosuppression treatment for anti-GBM disease complicated with IgA nephropathy
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- Eosinophils in Colorectal Neoplasms Associated with Expression of CCL11 and CCL24
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Hyuck Cho, Sung-Jig Lim, Kyu Yeoun Won, Go Eun Bae, Gou Young Kim, Ji Won Min, Byeong-joo Noh
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J Pathol Transl Med. 2016;50(1):45-51. Published online December 14, 2015
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DOI: https://doi.org/10.4132/jptm.2015.10.16
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- Background
A decrease in the number of tissue eosinophils is known to reflect the malignancy potential of neoplastic lesions and even prognosis. Increased levels of the chemokines CCL11 and CCL24 in serum and tissue are also known to have diagnostic value as serum tumor markers or prognostic factors. The aim of this study was to evaluate the correlation between the degree of tissue eosinophilia and the expression of these chemokines in the glandular and stromal cells of colorectal neoplastic lesions ranging from benign to malignant tumors. Methods: We counted the number of infiltrating eosinophils in neoplastic lesion tissue and we evaluated the expression of CCL11 and CCL24 in glandular cells and stromal cells by immunohistochemical staining. Results: The results showed that the number of eosinophils decreased significantly and the expression of CCL11 and CCL24 in glandular cells decreased with tumor progression, whereas the stromal expression of CCL11 and CCL24 appeared to increase. Conclusions: The discrepancy in CCL11 and CCL24 expression between glandular cells and stromal cells might shed light on how colorectal cancer evades the immune system, which would enable further development of immunotherapies that target these chemokines. Further research on eosinophil biology and the expression pattern of chemokines in tumor cells is needed.
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- Chronic Placental Inflammation in Twin Pregnancies
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Heejin Bang, Go Eun Bae, Ha Young Park, Yeon Mee Kim, Suk-Joo Choi, Soo-young Oh, Cheong-Rae Roh, Jung-Sun Kim
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J Pathol Transl Med. 2015;49(6):489-496. Published online October 13, 2015
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DOI: https://doi.org/10.4132/jptm.2015.09.09
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- Background
Chronic placental inflammation, such as villitis of unknown etiology (VUE) and chronic chorioamnionitis (CCA), is considered a placental manifestation of maternal anti-fetal rejection. The aim of this study is to investigate its frequency in twin pregnancies compared to singleton pregnancies. Methods: Three hundred twin placentas and 1,270 singleton placentas were consecutively collected at a tertiary medical center in Seoul, Republic of Korea from 2009 to 2012. Hematoxylin and eosin sections of tissue samples (full-thickness placental disc and chorioamniotic membranes) were reviewed. Results: Non-basal VUE was more frequent in twin placentas than in singleton placentas (6.0% vs 3.2%, p < .05). In preterm birth, CCA was found less frequently in twin placentas than in singleton placentas (9.6% vs 14.8%, p < .05), reaching its peak at an earlier gestational age in twin placentas (29–32 weeks) than in singleton placentas (33–36 weeks). CCA was more frequent in twin pregnancies with babies of a different sex than with those with the same sex (13.8% vs 6.9%, p = .052). Separate dichorionic diamniotic twin placentas were affected by chronic deciduitis more frequently than singleton placentas (16.9% vs 9.7%, p < .05). Conclusions: The higher frequency of non-basal VUE in twin placentas and of CCA in twin placentas with different fetal sex supports the hypothesis that the underlying pathophysiological mechanism is maternal anti-fetal rejection related to increased fetal antigens in twin pregnancies. The peak of CCA at an earlier gestational age in twin placentas than in singleton placentas suggests that CCA is influenced by placental maturation.
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Henning Feist, Ulrich Lehmann, Simin Bajwa, Corinna Brüschke, Nora Schaumann Placenta.2023; 133: 32. CrossRef - Discordant Eosinophilic/T-Cell Chorionic Vasculitis in a Dichorionic Diamniotic Placenta
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Sunil Jaiman, Roberto Romero, Percy Pacora, Eunjung Jung, Gaurav Bhatti, Lami Yeo, Yeon Mee Kim, Bomi Kim, Chong Jai Kim, Jung-Sun Kim, Faisal Qureshi, Suzanne M. Jacques, Offer Erez, Nardhy Gomez-Lopez, Chaur-Dong Hsu Journal of Perinatal Medicine.2020;[Epub] CrossRef - Biochemical predictors of preterm birth in twin pregnancies: A systematic review involving 6077 twin pregnancies
Shemoon Marleen, Chamalika Dias, Rebecca MacGregor, John Allotey, Joseph Aquilina, Asma Khalil, Shakila Thangaratinam European Journal of Obstetrics & Gynecology and Reproductive Biology.2020; 250: 130. CrossRef -
Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy
Duško Kljakić, Miloš Z. Milosavljević, Milan Jovanović, Vesna Čolaković Popović, Saša Raičević Open Medicine.2020; 16(1): 81. CrossRef - The frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes
Kyung Joon Oh, Joon-Seok Hong, Roberto Romero, Bo Hyun Yoon The Journal of Maternal-Fetal & Neonatal Medicine.2019; 32(4): 527. CrossRef - Discordance of Twin Placentas for Multifocal Eosinophilic/T-cell Chorionic Vasculitis
Erik W Nohr, James R Wright Pediatric and Developmental Pathology.2019; 22(1): 40. CrossRef - Differential immunophenotype of macrophages in acute and chronic chorioamnionitis
Go-Eun Bae, Joon-Seok Hong, Jung-Sun Kim, Ha Young Park, Ja Yun Jang, Yi Seul Kim, Suk-Joo Choi, Soo-young Oh, Cheong-Rae Roh Journal of Perinatal Medicine.2017; 45(4): 483. CrossRef - Fetal death: an extreme manifestation of maternal anti-fetal rejection
Kia Lannaman, Roberto Romero, Tinnakorn Chaiworapongsa, Yeon Mee Kim, Steven J. Korzeniewski, Eli Maymon, Nardhy Gomez-Lopez, Bogdan Panaitescu, Sonia S. Hassan, Lami Yeo, Bo Hyun Yoon, Chong Jai Kim, Offer Erez Journal of Perinatal Medicine.2017; 45(7): 851. CrossRef
- Morphologic Alteration of Metastatic Neuroblastic Tumor in Bone Marrow after Chemotherapy
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Go Eun Bae, Yeon-Lim Suh, Ki Woong Sung, Jung-Sun Kim
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Korean J Pathol. 2013;47(5):433-442. Published online October 25, 2013
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DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.433
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- Background
The aim of this study is to evaluate the histologic features of metastatic neuroblastic tumors (NTs) in bone marrow (BM) before and after chemotherapy in comparison with those of primary NTs. MethodsA total of 294 biopsies from 48 children diagnosed with NTs with BM metastasis were examined. There were 48 primary neoplasm biopsies, 48 BM biopsies before chemotherapy, 36 primary neoplasm excisional biopsies after chemotherapy, and 162 BM biopsies after chemotherapy. ResultsMetastatic NTs in BM before chemotherapy were composed of undifferentiated and/or differentiating neuroblasts, but had neither ganglion cells nor Schwannian stroma. Metastatic foci of BM after chemotherapy were found to have differentiated into ganglion cells or Schwannian stroma, which became more prominent after further cycles of chemotherapy. Persistence of NTs or tumor cell types in BM after treatment did not show statistically significant correlation to patients' outcome. However, three out of five patients who newly developed poorly differentiated neuroblasts in BM after treatment expired due to disease progression. ConclusionsMetastatic NTs in BM initially consist of undifferentiated or differentiating neuroblasts regardless of the primary tumor subtype, and become differentiated after chemotherapy. Newly appearing poorly differentiated neuroblasts after treatment might be an indicator for poor prognosis.
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Citations
Citations to this article as recorded by 
- Postchemotherapy gross residual tumor in non‐high‐risk neuroblastoma: Clinical significance and the role of adjuvant therapy
Eun Seop Seo, Hana Lim, Hee Won Cho, Hee Young Ju, Ji Won Lee, Keon Hee Yoo, Sanghoon Lee, Do Hoon Lim, Ki Woong Sung, Hong Hoe Koo Pediatric Blood & Cancer.2022;[Epub] CrossRef
- Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination
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Go Eun Bae, Nara Yoon, Ha Young Park, Sang Yun Ha, Junhun Cho, Yunkyung Lee, Kyoung-Mee Kim, Cheol Keun Park
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Korean J Pathol. 2013;47(2):163-166. Published online April 24, 2013
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DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.163
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Abstract
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Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 µm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.
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Citations
Citations to this article as recorded by 
- Malakoplakia in kidney transplant recipients: Three case reports
Prathap Kumar Simhadri, Renish Contractor, Deepak Chandramohan, Matthew McGee, Udit Nangia, Mohammad Atari, Syed Bushra, Sanjana Kapoor, Ramya Krishna Velagapudi, Pradeep K Vaitla World Journal of Nephrology.2025;[Epub] CrossRef - Caecal malakoplakia: a rare mimic of malignancy
Jeffrey Li Voon Chong, Noor Ali BMJ Case Reports.2024; 17(1): e257130. CrossRef - A Surgical Challenge Generated by Colonic Malakoplakia in Disguise as a Locally Advanced Colonic Malignancy—A Case Report
Cristina Șerban, Alexandra Toma, Dragoș Cristian Voicu, Constantin Popazu, Dorel Firescu, George Țocu, Raul Mihailov, Laura Rebegea Medicina.2023; 59(1): 156. CrossRef - Colonic malakoplakia in a cardiac transplant recipient: A case report
Sadiya Shafijan Indian Journal of Pathology and Microbiology.2020; 63(2): 322. CrossRef - Immunosuppressive drugs and the gastrointestinal tract in renal transplant patients
Merel M. Tielemans, Gerben A.J. van Boekel, Teun van Gelder, Eric T. Tjwa, Luuk B. Hilbrands Transplantation Reviews.2019; 33(2): 55. CrossRef - Malakoplakia of the colon following renal transplantation in a 73 year old woman: report of a case presenting as intestinal perforation
Andrew Mitchell, Alexandre Dugas Diagnostic Pathology.2019;[Epub] CrossRef - Colonic malakoplakia in a liver transplant recipient: A case report
Rana Ajabnoor, Mohammad Mawardi, Abdulmonem Almutawa Human Pathology: Case Reports.2019; 18: 200323. CrossRef - Malakoplakia after kidney transplantation: Case report and literature review
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