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Go Eun Bae 6 Articles
Cytopathologic features of human papillomavirus–independent, gastric-type endocervical adenocarcinoma
Min-Kyung Yeo, Go Eun Bae, Dong-Hyun Kim, In-Ock Seong, Kwang-Sun Suh
J Pathol Transl Med. 2022;56(5):260-269.   Published online September 13, 2022
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  • 77 Download
AbstractAbstract PDF
Gastric-type endocervical adenocarcinoma (GEA) is unrelated to human papillomavirus (HPV) infection and is clinically aggressive compared with HPV-associated usual-type endocervical adenocarcinoma (UEA). The cytological diagnosis falls short of a definitive diagnosis of GEA and is often categorized as atypical glandular cells (AGCs). To improve cytologic recognition, cytological findings of HPV-independent GEA were analyzed and the results compared with HPV-associated UEA.
Cervical Papanicolaou (Pap) smears from eight patients with a histopathologic diagnosis of GEA and 12 control cases of UEA were reviewed. All slides were conventionally prepared and/or liquid-based prepared (ThinPrep) and stained following the Pap method. A mucinous background, architectural, nuclear, and cytoplasmic features were analyzed and compared with UEA.
Preoperative cytologic diagnoses of the eight GEA cases were AGCs, favor neoplastic in three cases, adenocarcinoma in situ in one case, and adenocarcinoma in four cases. Cytologically, monolayered honeycomb-like sheets (p = .002) of atypical endocervical cells with vacuolar granular cytoplasm (p = .001) were extensive in GEA, and three-dimensional clusters (p = .010) were extensive in UEA. Although the differences were not statistically significant, background mucin (p = .058), vesicular nuclei (p = .057), and golden-brown intracytoplasmic mucin (p = .089) were also discriminatory findings for GEA versus UEA.
Although GEA is difficult to diagnose on cytologic screening, GEA can be recognized based on cytologic features of monolayered honeycomb sheets of atypical endocervical cells with abundant vacuolar cytoplasm and some golden-brown intracytoplasmic mucin. UEA cases are characterized by three-dimensional clusters.
Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy
Kwang-Sun Suh, Song-Yi Choi, Go Eun Bae, Dae Eun Choi, Min-kyung Yeo
J Pathol Transl Med. 2019;53(6):399-402.   Published online September 16, 2019
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  • 154 Download
  • 8 Citations
AbstractAbstract PDFSupplementary Material
Anti–glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of IgG along the GBM. In a limited number of cases, glomerular immune complexes have been identified in anti-GBM nephritis. A 38-year-old female presented azotemia, hematuria, and proteinuria without any pulmonary symptoms. A renal biopsy showed crescentic GN with linear IgG deposition along the GBM and mesangial IgA deposition. The patient was diagnosed as concurrent anti-GBM nephritis and IgA nephropathy. Therapies with pulse methylprednisolone and cyclophosphamide administration were effective. Concurrent cases of both anti-GBM nephritis and IgA nephropathy are rare among cases of anti-GBM diseases with deposition of immune complexes. This rare case of concurrent anti-GBM nephritis and IgA nephropathy with literature review is noteworthy.


Citations to this article as recorded by  
  • Anti-glomerular basement membrane vasculitis
    Claudio Ponticelli, Marta Calatroni, Gabriella Moroni
    Autoimmunity Reviews.2023; 22(1): 103212.     CrossRef
  • High-frequency plasma exchange therapy for immunocompromised, type I crescentic glomerulonephritis complicated with IgA nephropathy: A case report and literature review
    Huihui Chen, Jingjing Jin, Mei Juan Cheng, Lei He, Wei Zhou, Liping Guo, Zhe Zhe Niu, Xiang Nan Liang, Rong Fang Zhu, Yaling Bai, Jin Sheng Xu
    Medicine.2023; 102(3): e32698.     CrossRef
  • Anti-glomerular basement membrane disease with IgA nephropathy: A case report
    Chuan Guo, Ming Ye, Shen Li, Ting-Ting Zhu, Xiang-Rong Rao
    World Journal of Clinical Cases.2022; 10(12): 3916.     CrossRef
  • Case Report: Coexistence of Anti-Glomerular Basement Membrane Disease, Membranous Nephropathy, and IgA Nephropathy in a Female PatientWith Preserved Renal Function
    Wei Qu, Nan Liu, Tianhua Xu, Binyao Tian, Meng Wang, Yanqiu Li, Jianfei Ma, Li Yao
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Great prognosis of concurrent anti-GBM disease and IgA nephropathy in a young woman: A case report
    Fu Shaojie, Su Sensen, Huang Jingda, Wang Luyu, Zhang Fei, Yu Jinyu, Xu Zhonggao, Wu Hao
    Medicine.2022; 101(37): e30686.     CrossRef
  • Serodiagnosis of Anti-glomerular Basement Membrane Disease Using a Newly Developed Chemiluminescence Immunoassay
    Alexander Kühnl, Lea Hartwig, Cornelia Dähnrich, Wolfgang Schlumberger
    Frontiers in Medicine.2022;[Epub]     CrossRef
    Keya Basu, Dipankar Sircar, Manimoy Bandopadhyay
  • Pneumocystis pneumonia secondary to intensive immunosuppression treatment for anti-GBM disease complicated with IgA nephropathy
    Manyu Zhang, Dingwei Yang, Weixiu Wang, Fuhao Zhao, Xiaoxiao Zhang, Xue Li
    Medicine.2021; 100(45): e27728.     CrossRef
Eosinophils in Colorectal Neoplasms Associated with Expression of CCL11 and CCL24
Hyuck Cho, Sung-Jig Lim, Kyu Yeoun Won, Go Eun Bae, Gou Young Kim, Ji Won Min, Byeong-joo Noh
J Pathol Transl Med. 2016;50(1):45-51.   Published online December 14, 2015
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  • 31 Citations
AbstractAbstract PDF
A decrease in the number of tissue eosinophils is known to reflect the malignancy potential of neoplastic lesions and even prognosis. Increased levels of the chemokines CCL11 and CCL24 in serum and tissue are also known to have diagnostic value as serum tumor markers or prognostic factors. The aim of this study was to evaluate the correlation between the degree of tissue eosinophilia and the expression of these chemokines in the glandular and stromal cells of colorectal neoplastic lesions ranging from benign to malignant tumors. Methods: We counted the number of infiltrating eosinophils in neoplastic lesion tissue and we evaluated the expression of CCL11 and CCL24 in glandular cells and stromal cells by immunohistochemical staining. Results: The results showed that the number of eosinophils decreased significantly and the expression of CCL11 and CCL24 in glandular cells decreased with tumor progression, whereas the stromal expression of CCL11 and CCL24 appeared to increase. Conclusions: The discrepancy in CCL11 and CCL24 expression between glandular cells and stromal cells might shed light on how colorectal cancer evades the immune system, which would enable further development of immunotherapies that target these chemokines. Further research on eosinophil biology and the expression pattern of chemokines in tumor cells is needed.


Citations to this article as recorded by  
  • Eosinophilia in cancer and its regulation by sex hormones
    Sandeep Artham, Ching-Yi Chang, Donald P. McDonnell
    Trends in Endocrinology & Metabolism.2023; 34(1): 5.     CrossRef
  • Systemic Evaluation of the Effect of Diabetes Mellitus on Breast Cancer in a Mouse Model
    Nana Wei, Jinmiao Lu, Zhibing Lin, Xiaoyu Wang, Mengmeng Cai, Shengyao Jiang, Xiaoyu Chen, Shilan Zhu, Dong Zhang, Li Cui
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Extracellular DNA Traps: Origin, Function and Implications for Anti-Cancer Therapies
    Medina Mamtimin, Akif Pinarci, Chao Han, Attila Braun, Hans-Joachim Anders, Thomas Gudermann, Elmina Mammadova-Bach
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Immune-Related Biomarkers Associated with Lung Metastasis from the Colorectal Cancer Microenvironment
    Wang Da, Wu Yinhang, Zhuang Jing, Xu Jiamin, Gao Xinyi, Song Yongmao, Pan Yuefen
    Journal of Interferon & Cytokine Research.2022; 42(5): 220.     CrossRef
  • Cancer-Associated Fibroblasts Promote Tumor Aggressiveness in Head and Neck Cancer through Chemokine Ligand 11 and C-C Motif Chemokine Receptor 3 Signaling Circuit
    Wen-Yen Huang, Yaoh-Shiang Lin, Yu-Chun Lin, Shin Nieh, Yi-Ming Chang, Tsai-Yu Lee, Su-Feng Chen, Kuender D. Yang
    Cancers.2022; 14(13): 3141.     CrossRef
  • Eosinophils Decrease Pulmonary Metastatic Mammary Tumor Growth
    Rachel A. Cederberg, Sarah Elizabeth Franks, Brennan J. Wadsworth, Alvina So, Lisa R. Decotret, Michael G. Hall, Rocky Shi, Michael R. Hughes, Kelly M. McNagny, Kevin L. Bennewith
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • An Immune-Related Prognostic Risk Model in Colon Cancer by Bioinformatics Analysis
    Qing Lai, Haifei Feng, Shuli Yang
    Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
  • Epitope Mapping of Anti-Mouse CCR3 Monoclonal Antibodies Using Flow Cytometry
    Nami Tateyama, Teizo Asano, Hiroyuki Suzuki, Guanjie Li, Takeo Yoshikawa, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato
    Antibodies.2022; 11(4): 75.     CrossRef
  • Granulocytes and Cells of Granulocyte Origin—The Relevant Players in Colorectal Cancer
    Izabela Siemińska, Ewa Poljańska, Jarek Baran
    International Journal of Molecular Sciences.2021; 22(7): 3801.     CrossRef
  • CCL24 Protects Renal Function by Controlling Inflammation in Podocytes
    Youdi Wang, Xue Wu, Mengya Geng, Jiamin Ding, Kangjia Lv, Hui Du, Jiahui Ding, Wenjun Pei, Xin Hu, Jing Gu, Lizhuo Wang, Yao Zhang, Jialin Gao, Roberta Rizzo
    Disease Markers.2021; 2021: 1.     CrossRef
  • Primary tumors from mucosal barrier organs drive unique eosinophil infiltration patterns and clinical associations
    Sharon Grisaru-Tal, Michal Itan, Daniel G Grass, Javier Torres-Roca, Steven A Eschrich, Yaara Gordon, Avishay Dolitzky, Inbal Hazut, Shmuel Avlas, Elizabeth A Jacobsen, Tomer Ziv-Baran, Ariel Munitz
    OncoImmunology.2021;[Epub]     CrossRef
  • Discovery of core gene families associated with liver metastasis in colorectal cancer and regulatory roles in tumor cell immune infiltration
    Wei-Qing Liu, Wen-Liang Li, Shu-Min Ma, Lei Liang, Zhi-Yong Kou, Jun Yang
    Translational Oncology.2021; 14(3): 101011.     CrossRef
  • Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity
    Sharon Grisaru-Tal, Shai Dulberg, Lir Beck, Chunyan Zhang, Michal Itan, Soroor Hediyeh-zadeh, Julie Caldwell, Perri Rozenberg, Avishay Dolitzky, Shmuel Avlas, Inbal Hazut, Yaara Gordon, Ophir Shani, Shlomo Tsuriel, Motti Gerlic, Neta Erez, Nicolas Jacquel
    Cancer Research.2021; 81(21): 5555.     CrossRef
  • Tumor Immunology and Tumor Evolution: Intertwined Histories
    Jérôme Galon, Daniela Bruni
    Immunity.2020; 52(1): 55.     CrossRef
  • A new dawn for eosinophils in the tumour microenvironment
    Sharon Grisaru-Tal, Michal Itan, Amy D. Klion, Ariel Munitz
    Nature Reviews Cancer.2020; 20(10): 594.     CrossRef
  • Eotaxins and Their Receptor in Colorectal Cancer—A Literature Review
    Monika Zajkowska, Barbara Mroczko
    Cancers.2020; 12(6): 1383.     CrossRef
  • Eosinophilic peritonitis with colon cancer: a case report
    Ryo Ataka, Hirokazu Tanaka, Shintaro Yagi, Kei Yamane, Kenji Yoshino, Tomoyuki Miyauchi, Tomoaki Yoh, Keiichi Arafuka, Shinichi Fujita, Akihiko Hamada, Bunji Endo, Shinji Uemoto
    BMC Gastroenterology.2020;[Epub]     CrossRef
  • Hypoxia Alters the Expression of CC Chemokines and CC Chemokine Receptors in a Tumor–A Literature Review
    Jan Korbecki, Klaudyna Kojder, Katarzyna Barczak, Donata Simińska, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
    International Journal of Molecular Sciences.2020; 21(16): 5647.     CrossRef
  • CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4
    Jan Korbecki, Klaudyna Kojder, Donata Simińska, Romuald Bohatyrewicz, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
    International Journal of Molecular Sciences.2020; 21(21): 8412.     CrossRef
  • Opposing roles of eosinophils in cancer
    Sonja C. S. Simon, Jochen Utikal, Viktor Umansky
    Cancer Immunology, Immunotherapy.2019; 68(5): 823.     CrossRef
  • Prognostic significance of inflammatory cell response in patients with colorectal cancer
    Katarzyna Jakubowska, Mariusz Koda, Wojciech Kisielewski, Luiza Kańczuga‑Koda, Waldemar Famulski
    Oncology Letters.2019;[Epub]     CrossRef
  • Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer
    Hadar Reichman, Michal Itan, Perri Rozenberg, Tal Yarmolovski, Eli Brazowski, Chen Varol, Nathan Gluck, Shiran Shapira, Nadir Arber, Udi Qimron, Danielle Karo-Atar, James J. Lee, Ariel Munitz
    Cancer Immunology Research.2019; 7(3): 388.     CrossRef
  • Developmental endothelial locus-1 (Del-1) antagonizes Interleukin-17-mediated allergic asthma
    Shu Yan, Li Chen, Qi Zhao, Ya-Nan Liu, Rui Hou, Jing Yu, Hong Zhang
    Immunology and Cell Biology.2018; 96(5): 526.     CrossRef
  • Expression of Galectins-1 and Galectin-3 in Stomach and Colorectal Cancer with Tissue Eosinophilia
    Yu. V. Kolobovnikova, A. I. Dmitrieva, K. I. Yankovich, O. A. Vasil’eva, I. L. Purlik, V. S. Poletika, V. V. Novitskii, O. I. Urazova
    Bulletin of Experimental Biology and Medicine.2018; 165(2): 256.     CrossRef
  • The expression of CCL11/eotaxin, CCR3 receptor and eosinophil peroxidase in tumor tissue in gastric and colon cancers
    Yu. V. Kolobovnikova, K. I. Yankovich, E. V. Romanova, A. I. Dmitrieva, V. V. Novitskiy, O. I. Urazova
    Bulletin of Siberian Medicine.2018; 17(3): 80.     CrossRef
  • Friend or foe?
    Tommaso Colangelo, Giovanna Polcaro, Livio Muccillo, Giovanna D'Agostino, Valeria Rosato, Pamela Ziccardi, Angelo Lupo, Gianluigi Mazzoccoli, Lina Sabatino, Vittorio Colantuoni
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2017; 1867(1): 1.     CrossRef
  • CCL24 contributes to HCC malignancy via RhoB- VEGFA-VEGFR2 angiogenesis pathway and indicates poor prognosis
    Lei Jin, Wei-Ren Liu, Meng-Xin Tian, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Ying-Hong Shi
    Oncotarget.2017; 8(3): 5135.     CrossRef
  • Inflammatory cytokines are associated with response and prognosis in patients with esophageal cancer
    Susanne Blank, Henrik Nienhüser, Lena Dreikhausen, Leila Sisic, Ulrike Heger, Katja Ott, Thomas Schmidt
    Oncotarget.2017; 8(29): 47518.     CrossRef
  • The formation mechanisms of tumor-associated tissue eosinophilia in gastric cancer and colon cancer
    В.В. Новицкий, К.И. Янкович, Ю.В. Колобовникова, А.И. Дмитриева, О.И. Уразова, И.Л. Пурлик, Л.А. Кудяков, С.П. Чумакова
    ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia».2017; (4(61)): 74.     CrossRef
  • LncRNAs expression in adjuvant-induced arthritis rats reveals the potential role of LncRNAs contributing to rheumatoid arthritis pathogenesis
    Hui Jiang, Xiu-Juan Qin, Wei-Ping Li, Rong Ma, Ting Wang, Zhu-Qing Li
    Gene.2016; 593(1): 131.     CrossRef
  • Emerging Roles for Eosinophils in the Tumor Microenvironment
    Hadar Reichman, Danielle Karo-Atar, Ariel Munitz
    Trends in Cancer.2016; 2(11): 664.     CrossRef
Chronic Placental Inflammation in Twin Pregnancies
Heejin Bang, Go Eun Bae, Ha Young Park, Yeon Mee Kim, Suk-Joo Choi, Soo-young Oh, Cheong-Rae Roh, Jung-Sun Kim
J Pathol Transl Med. 2015;49(6):489-496.   Published online October 13, 2015
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  • 70 Download
  • 10 Citations
AbstractAbstract PDF
Chronic placental inflammation, such as villitis of unknown etiology (VUE) and chronic chorioamnionitis (CCA), is considered a placental manifestation of maternal anti-fetal rejection. The aim of this study is to investigate its frequency in twin pregnancies compared to singleton pregnancies. Methods: Three hundred twin placentas and 1,270 singleton placentas were consecutively collected at a tertiary medical center in Seoul, Republic of Korea from 2009 to 2012. Hematoxylin and eosin sections of tissue samples (full-thickness placental disc and chorioamniotic membranes) were reviewed. Results: Non-basal VUE was more frequent in twin placentas than in singleton placentas (6.0% vs 3.2%, p < .05). In preterm birth, CCA was found less frequently in twin placentas than in singleton placentas (9.6% vs 14.8%, p < .05), reaching its peak at an earlier gestational age in twin placentas (29–32 weeks) than in singleton placentas (33–36 weeks). CCA was more frequent in twin pregnancies with babies of a different sex than with those with the same sex (13.8% vs 6.9%, p = .052). Separate dichorionic diamniotic twin placentas were affected by chronic deciduitis more frequently than singleton placentas (16.9% vs 9.7%, p < .05). Conclusions: The higher frequency of non-basal VUE in twin placentas and of CCA in twin placentas with different fetal sex supports the hypothesis that the underlying pathophysiological mechanism is maternal anti-fetal rejection related to increased fetal antigens in twin pregnancies. The peak of CCA at an earlier gestational age in twin placentas than in singleton placentas suggests that CCA is influenced by placental maturation.


Citations to this article as recorded by  
  • Villitis of unknown etiology, chronic deciduitis, chronic chorioamnionitis and chronic histiocytic intervillositis in monozygotic and dizygotic twin pregnancies. A retrospective analysis of 16 cases
    Henning Feist, Ulrich Lehmann, Simin Bajwa, Corinna Brüschke, Nora Schaumann
    Placenta.2023; 133: 32.     CrossRef
  • Histopathologic evaluation of dichorionic twin placentas in unassisted and in vitro fertilized pregnancies affected by preeclampsia
    Evelina Manvelyan, Karmaine A. Millington, Baruch S. Abittan, Matthew J. Blitz, Brittany Kwait, Weiwei Shan, Randi H. Goldman
    The Journal of Maternal-Fetal & Neonatal Medicine.2022; 35(26): 10262.     CrossRef
  • Microbiological safety of the Dr. Arabin cervical pessary in pregnant women with short cervix
    Gabriel S. Sargsyan, Olesya N. Bespalova, Alevtina M. Savicheva, Tatyana A. Khusnutdinova, Olga V. Budilovskaya, Anna A. Krysanova, Kira V. Shalepo
    Journal of obstetrics and women's diseases.2022; 71(5): 65.     CrossRef
  • Disorders of placental villous maturation in fetal death
    Sunil Jaiman, Roberto Romero, Percy Pacora, Eunjung Jung, Gaurav Bhatti, Lami Yeo, Yeon Mee Kim, Bomi Kim, Chong Jai Kim, Jung-Sun Kim, Faisal Qureshi, Suzanne M. Jacques, Offer Erez, Nardhy Gomez-Lopez, Chaur-Dong Hsu
    Journal of Perinatal Medicine.2020;[Epub]     CrossRef
  • Biochemical predictors of preterm birth in twin pregnancies: A systematic review involving 6077 twin pregnancies
    Shemoon Marleen, Chamalika Dias, Rebecca MacGregor, John Allotey, Joseph Aquilina, Asma Khalil, Shakila Thangaratinam
    European Journal of Obstetrics & Gynecology and Reproductive Biology.2020; 250: 130.     CrossRef
  • Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy
    Duško Kljakić, Miloš Z. Milosavljević, Milan Jovanović, Vesna Čolaković Popović, Saša Raičević
    Open Medicine.2020; 16(1): 81.     CrossRef
  • The frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes
    Kyung Joon Oh, Joon-Seok Hong, Roberto Romero, Bo Hyun Yoon
    The Journal of Maternal-Fetal & Neonatal Medicine.2019; 32(4): 527.     CrossRef
  • Discordance of Twin Placentas for Multifocal Eosinophilic/T-cell Chorionic Vasculitis
    Erik W Nohr, James R Wright
    Pediatric and Developmental Pathology.2019; 22(1): 40.     CrossRef
  • Differential immunophenotype of macrophages in acute and chronic chorioamnionitis
    Go-Eun Bae, Joon-Seok Hong, Jung-Sun Kim, Ha Young Park, Ja Yun Jang, Yi Seul Kim, Suk-Joo Choi, Soo-young Oh, Cheong-Rae Roh
    Journal of Perinatal Medicine.2017;[Epub]     CrossRef
  • Fetal death: an extreme manifestation of maternal anti-fetal rejection
    Kia Lannaman, Roberto Romero, Tinnakorn Chaiworapongsa, Yeon Mee Kim, Steven J. Korzeniewski, Eli Maymon, Nardhy Gomez-Lopez, Bogdan Panaitescu, Sonia S. Hassan, Lami Yeo, Bo Hyun Yoon, Chong Jai Kim, Offer Erez
    Journal of Perinatal Medicine.2017;[Epub]     CrossRef
Morphologic Alteration of Metastatic Neuroblastic Tumor in Bone Marrow after Chemotherapy
Go Eun Bae, Yeon-Lim Suh, Ki Woong Sung, Jung-Sun Kim
Korean J Pathol. 2013;47(5):433-442.   Published online October 25, 2013
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  • 36 Download
  • 1 Citations
AbstractAbstract PDF

The aim of this study is to evaluate the histologic features of metastatic neuroblastic tumors (NTs) in bone marrow (BM) before and after chemotherapy in comparison with those of primary NTs.


A total of 294 biopsies from 48 children diagnosed with NTs with BM metastasis were examined. There were 48 primary neoplasm biopsies, 48 BM biopsies before chemotherapy, 36 primary neoplasm excisional biopsies after chemotherapy, and 162 BM biopsies after chemotherapy.


Metastatic NTs in BM before chemotherapy were composed of undifferentiated and/or differentiating neuroblasts, but had neither ganglion cells nor Schwannian stroma. Metastatic foci of BM after chemotherapy were found to have differentiated into ganglion cells or Schwannian stroma, which became more prominent after further cycles of chemotherapy. Persistence of NTs or tumor cell types in BM after treatment did not show statistically significant correlation to patients' outcome. However, three out of five patients who newly developed poorly differentiated neuroblasts in BM after treatment expired due to disease progression.


Metastatic NTs in BM initially consist of undifferentiated or differentiating neuroblasts regardless of the primary tumor subtype, and become differentiated after chemotherapy. Newly appearing poorly differentiated neuroblasts after treatment might be an indicator for poor prognosis.


Citations to this article as recorded by  
  • Postchemotherapy gross residual tumor in non‐high‐risk neuroblastoma: Clinical significance and the role of adjuvant therapy
    Eun Seop Seo, Hana Lim, Hee Won Cho, Hee Young Ju, Ji Won Lee, Keon Hee Yoo, Sanghoon Lee, Do Hoon Lim, Ki Woong Sung, Hong Hoe Koo
    Pediatric Blood & Cancer.2022;[Epub]     CrossRef
Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination
Go Eun Bae, Nara Yoon, Ha Young Park, Sang Yun Ha, Junhun Cho, Yunkyung Lee, Kyoung-Mee Kim, Cheol Keun Park
Korean J Pathol. 2013;47(2):163-166.   Published online April 24, 2013
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  • 54 Download
  • 7 Citations
AbstractAbstract PDF

Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 µm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.


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  • A Surgical Challenge Generated by Colonic Malakoplakia in Disguise as a Locally Advanced Colonic Malignancy—A Case Report
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    Medicina.2023; 59(1): 156.     CrossRef
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    Indian Journal of Pathology and Microbiology.2020; 63(2): 322.     CrossRef
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    Merel M. Tielemans, Gerben A.J. van Boekel, Teun van Gelder, Eric T. Tjwa, Luuk B. Hilbrands
    Transplantation Reviews.2019; 33(2): 55.     CrossRef
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    Andrew Mitchell, Alexandre Dugas
    Diagnostic Pathology.2019;[Epub]     CrossRef
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    Rana Ajabnoor, Mohammad Mawardi, Abdulmonem Almutawa
    Human Pathology: Case Reports.2019; 18: 200323.     CrossRef
  • Malakoplakia after kidney transplantation: Case report and literature review
    John Fredy Nieto-Ríos, Isabel Ramírez, Mónica Zuluaga-Quintero, Lina María Serna-Higuita, Federico Gaviria-Gil, Alejandro Velez-Hoyos
    Transplant Infectious Disease.2017; 19(5): e12731.     CrossRef
  • Megalocytic Interstitial Nephritis Following Acute Pyelonephritis with Escherichia coli Bacteremia: A Case Report
    Hee Jin Kwon, Kwai Han Yoo, In Young Kim, Seulkee Lee, Hye Ryoun Jang, Ghee Young Kwon
    Journal of Korean Medical Science.2015; 30(1): 110.     CrossRef

JPTM : Journal of Pathology and Translational Medicine