- Cytopathologic features of human papillomavirus–independent, gastric-type endocervical adenocarcinoma
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Min-Kyung Yeo, Go Eun Bae, Dong-Hyun Kim, In-Ock Seong, Kwang-Sun Suh
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J Pathol Transl Med. 2022;56(5):260-269. Published online September 13, 2022
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DOI: https://doi.org/10.4132/jptm.2022.07.05
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Abstract
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- Background
Gastric-type endocervical adenocarcinoma (GEA) is unrelated to human papillomavirus (HPV) infection and is clinically aggressive compared with HPV-associated usual-type endocervical adenocarcinoma (UEA). The cytological diagnosis falls short of a definitive diagnosis of GEA and is often categorized as atypical glandular cells (AGCs). To improve cytologic recognition, cytological findings of HPV-independent GEA were analyzed and the results compared with HPV-associated UEA.
Methods Cervical Papanicolaou (Pap) smears from eight patients with a histopathologic diagnosis of GEA and 12 control cases of UEA were reviewed. All slides were conventionally prepared and/or liquid-based prepared (ThinPrep) and stained following the Pap method. A mucinous background, architectural, nuclear, and cytoplasmic features were analyzed and compared with UEA.
Results Preoperative cytologic diagnoses of the eight GEA cases were AGCs, favor neoplastic in three cases, adenocarcinoma in situ in one case, and adenocarcinoma in four cases. Cytologically, monolayered honeycomb-like sheets (p = .002) of atypical endocervical cells with vacuolar granular cytoplasm (p = .001) were extensive in GEA, and three-dimensional clusters (p = .010) were extensive in UEA. Although the differences were not statistically significant, background mucin (p = .058), vesicular nuclei (p = .057), and golden-brown intracytoplasmic mucin (p = .089) were also discriminatory findings for GEA versus UEA.
Conclusions Although GEA is difficult to diagnose on cytologic screening, GEA can be recognized based on cytologic features of monolayered honeycomb sheets of atypical endocervical cells with abundant vacuolar cytoplasm and some golden-brown intracytoplasmic mucin. UEA cases are characterized by three-dimensional clusters.
- Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy
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Kwang-Sun Suh, Song-Yi Choi, Go Eun Bae, Dae Eun Choi, Min-kyung Yeo
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J Pathol Transl Med. 2019;53(6):399-402. Published online September 16, 2019
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DOI: https://doi.org/10.4132/jptm.2019.08.05
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- Anti–glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of IgG along the GBM. In a limited number of cases, glomerular immune complexes have been identified in anti-GBM nephritis. A 38-year-old female presented azotemia, hematuria, and proteinuria without any pulmonary symptoms. A renal biopsy showed crescentic GN with linear IgG deposition along the GBM and mesangial IgA deposition. The patient was diagnosed as concurrent anti-GBM nephritis and IgA nephropathy. Therapies with pulse methylprednisolone and cyclophosphamide administration were effective. Concurrent cases of both anti-GBM nephritis and IgA nephropathy are rare among cases of anti-GBM diseases with deposition of immune complexes. This rare case of concurrent anti-GBM nephritis and IgA nephropathy with literature review is noteworthy.
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Wei Qu, Nan Liu, Tianhua Xu, Binyao Tian, Meng Wang, Yanqiu Li, Jianfei Ma, Li Yao Frontiers in Pharmacology.2022;[Epub] CrossRef - Great prognosis of concurrent anti-GBM disease and IgA nephropathy in a young woman: A case report
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Alexander Kühnl, Lea Hartwig, Cornelia Dähnrich, Wolfgang Schlumberger Frontiers in Medicine.2022;[Epub] CrossRef - PATHOLOGY AND RENAL OUTCOME OF THREE UNCOMMON FACES OF CRESCENTRIC GLOMERULONEPHRITIS
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- Eosinophils in Colorectal Neoplasms Associated with Expression of CCL11 and CCL24
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Hyuck Cho, Sung-Jig Lim, Kyu Yeoun Won, Go Eun Bae, Gou Young Kim, Ji Won Min, Byeong-joo Noh
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J Pathol Transl Med. 2016;50(1):45-51. Published online December 14, 2015
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DOI: https://doi.org/10.4132/jptm.2015.10.16
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8,264
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- Background
A decrease in the number of tissue eosinophils is known to reflect the malignancy potential of neoplastic lesions and even prognosis. Increased levels of the chemokines CCL11 and CCL24 in serum and tissue are also known to have diagnostic value as serum tumor markers or prognostic factors. The aim of this study was to evaluate the correlation between the degree of tissue eosinophilia and the expression of these chemokines in the glandular and stromal cells of colorectal neoplastic lesions ranging from benign to malignant tumors. Methods: We counted the number of infiltrating eosinophils in neoplastic lesion tissue and we evaluated the expression of CCL11 and CCL24 in glandular cells and stromal cells by immunohistochemical staining. Results: The results showed that the number of eosinophils decreased significantly and the expression of CCL11 and CCL24 in glandular cells decreased with tumor progression, whereas the stromal expression of CCL11 and CCL24 appeared to increase. Conclusions: The discrepancy in CCL11 and CCL24 expression between glandular cells and stromal cells might shed light on how colorectal cancer evades the immune system, which would enable further development of immunotherapies that target these chemokines. Further research on eosinophil biology and the expression pattern of chemokines in tumor cells is needed.
-
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- Eosinophilia in cancer and its regulation by sex hormones
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Rachel A. Cederberg, Sarah Elizabeth Franks, Brennan J. Wadsworth, Alvina So, Lisa R. Decotret, Michael G. Hall, Rocky Shi, Michael R. Hughes, Kelly M. McNagny, Kevin L. Bennewith Frontiers in Oncology.2022;[Epub] CrossRef - An Immune-Related Prognostic Risk Model in Colon Cancer by Bioinformatics Analysis
Qing Lai, Haifei Feng, Shuli Yang Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1. CrossRef - Epitope Mapping of Anti-Mouse CCR3 Monoclonal Antibodies Using Flow Cytometry
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Izabela Siemińska, Ewa Poljańska, Jarek Baran International Journal of Molecular Sciences.2021; 22(7): 3801. CrossRef - CCL24 Protects Renal Function by Controlling Inflammation in Podocytes
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Wei-Qing Liu, Wen-Liang Li, Shu-Min Ma, Lei Liang, Zhi-Yong Kou, Jun Yang Translational Oncology.2021; 14(3): 101011. CrossRef - Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity
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Jérôme Galon, Daniela Bruni Immunity.2020; 52(1): 55. CrossRef - A new dawn for eosinophils in the tumour microenvironment
Sharon Grisaru-Tal, Michal Itan, Amy D. Klion, Ariel Munitz Nature Reviews Cancer.2020; 20(10): 594. CrossRef - Eotaxins and Their Receptor in Colorectal Cancer—A Literature Review
Monika Zajkowska, Barbara Mroczko Cancers.2020; 12(6): 1383. CrossRef - Eosinophilic peritonitis with colon cancer: a case report
Ryo Ataka, Hirokazu Tanaka, Shintaro Yagi, Kei Yamane, Kenji Yoshino, Tomoyuki Miyauchi, Tomoaki Yoh, Keiichi Arafuka, Shinichi Fujita, Akihiko Hamada, Bunji Endo, Shinji Uemoto BMC Gastroenterology.2020;[Epub] CrossRef - Hypoxia Alters the Expression of CC Chemokines and CC Chemokine Receptors in a Tumor–A Literature Review
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Jan Korbecki, Klaudyna Kojder, Donata Simińska, Romuald Bohatyrewicz, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka International Journal of Molecular Sciences.2020; 21(21): 8412. CrossRef - Opposing roles of eosinophils in cancer
Sonja C. S. Simon, Jochen Utikal, Viktor Umansky Cancer Immunology, Immunotherapy.2019; 68(5): 823. CrossRef - Prognostic significance of inflammatory cell response in patients with colorectal cancer
Katarzyna Jakubowska, Mariusz Koda, Wojciech Kisielewski, Luiza Kańczuga‑Koda, Waldemar Famulski Oncology Letters.2019;[Epub] CrossRef - Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer
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Shu Yan, Li Chen, Qi Zhao, Ya-Nan Liu, Rui Hou, Jing Yu, Hong Zhang Immunology and Cell Biology.2018; 96(5): 526. CrossRef - Expression of Galectins-1 and Galectin-3 in Stomach and Colorectal Cancer with Tissue Eosinophilia
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Yu. V. Kolobovnikova, K. I. Yankovich, E. V. Romanova, A. I. Dmitrieva, V. V. Novitskiy, O. I. Urazova Bulletin of Siberian Medicine.2018; 17(3): 80. CrossRef - Friend or foe?
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Susanne Blank, Henrik Nienhüser, Lena Dreikhausen, Leila Sisic, Ulrike Heger, Katja Ott, Thomas Schmidt Oncotarget.2017; 8(29): 47518. CrossRef - The formation mechanisms of tumor-associated tissue eosinophilia in gastric cancer and colon cancer
В.В. Новицкий, К.И. Янкович, Ю.В. Колобовникова, А.И. Дмитриева, О.И. Уразова, И.Л. Пурлик, Л.А. Кудяков, С.П. Чумакова ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia».2017; (4(61)): 74. CrossRef - LncRNAs expression in adjuvant-induced arthritis rats reveals the potential role of LncRNAs contributing to rheumatoid arthritis pathogenesis
Hui Jiang, Xiu-Juan Qin, Wei-Ping Li, Rong Ma, Ting Wang, Zhu-Qing Li Gene.2016; 593(1): 131. CrossRef - Emerging Roles for Eosinophils in the Tumor Microenvironment
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- Chronic Placental Inflammation in Twin Pregnancies
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Heejin Bang, Go Eun Bae, Ha Young Park, Yeon Mee Kim, Suk-Joo Choi, Soo-young Oh, Cheong-Rae Roh, Jung-Sun Kim
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J Pathol Transl Med. 2015;49(6):489-496. Published online October 13, 2015
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DOI: https://doi.org/10.4132/jptm.2015.09.09
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8,415
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- Background
Chronic placental inflammation, such as villitis of unknown etiology (VUE) and chronic chorioamnionitis (CCA), is considered a placental manifestation of maternal anti-fetal rejection. The aim of this study is to investigate its frequency in twin pregnancies compared to singleton pregnancies. Methods: Three hundred twin placentas and 1,270 singleton placentas were consecutively collected at a tertiary medical center in Seoul, Republic of Korea from 2009 to 2012. Hematoxylin and eosin sections of tissue samples (full-thickness placental disc and chorioamniotic membranes) were reviewed. Results: Non-basal VUE was more frequent in twin placentas than in singleton placentas (6.0% vs 3.2%, p < .05). In preterm birth, CCA was found less frequently in twin placentas than in singleton placentas (9.6% vs 14.8%, p < .05), reaching its peak at an earlier gestational age in twin placentas (29–32 weeks) than in singleton placentas (33–36 weeks). CCA was more frequent in twin pregnancies with babies of a different sex than with those with the same sex (13.8% vs 6.9%, p = .052). Separate dichorionic diamniotic twin placentas were affected by chronic deciduitis more frequently than singleton placentas (16.9% vs 9.7%, p < .05). Conclusions: The higher frequency of non-basal VUE in twin placentas and of CCA in twin placentas with different fetal sex supports the hypothesis that the underlying pathophysiological mechanism is maternal anti-fetal rejection related to increased fetal antigens in twin pregnancies. The peak of CCA at an earlier gestational age in twin placentas than in singleton placentas suggests that CCA is influenced by placental maturation.
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- Villitis of unknown etiology, chronic deciduitis, chronic chorioamnionitis and chronic histiocytic intervillositis in monozygotic and dizygotic twin pregnancies. A retrospective analysis of 16 cases
Henning Feist, Ulrich Lehmann, Simin Bajwa, Corinna Brüschke, Nora Schaumann Placenta.2023; 133: 32. CrossRef - Histopathologic evaluation of dichorionic twin placentas in unassisted and in vitro fertilized pregnancies affected by preeclampsia
Evelina Manvelyan, Karmaine A. Millington, Baruch S. Abittan, Matthew J. Blitz, Brittany Kwait, Weiwei Shan, Randi H. Goldman The Journal of Maternal-Fetal & Neonatal Medicine.2022; 35(26): 10262. CrossRef - Microbiological safety of the Dr. Arabin cervical pessary in pregnant women with short cervix
Gabriel S. Sargsyan, Olesya N. Bespalova, Alevtina M. Savicheva, Tatyana A. Khusnutdinova, Olga V. Budilovskaya, Anna A. Krysanova, Kira V. Shalepo Journal of obstetrics and women's diseases.2022; 71(5): 65. CrossRef - Disorders of placental villous maturation in fetal death
Sunil Jaiman, Roberto Romero, Percy Pacora, Eunjung Jung, Gaurav Bhatti, Lami Yeo, Yeon Mee Kim, Bomi Kim, Chong Jai Kim, Jung-Sun Kim, Faisal Qureshi, Suzanne M. Jacques, Offer Erez, Nardhy Gomez-Lopez, Chaur-Dong Hsu Journal of Perinatal Medicine.2020;[Epub] CrossRef - Biochemical predictors of preterm birth in twin pregnancies: A systematic review involving 6077 twin pregnancies
Shemoon Marleen, Chamalika Dias, Rebecca MacGregor, John Allotey, Joseph Aquilina, Asma Khalil, Shakila Thangaratinam European Journal of Obstetrics & Gynecology and Reproductive Biology.2020; 250: 130. CrossRef -
Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy
Duško Kljakić, Miloš Z. Milosavljević, Milan Jovanović, Vesna Čolaković Popović, Saša Raičević Open Medicine.2020; 16(1): 81. CrossRef - The frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes
Kyung Joon Oh, Joon-Seok Hong, Roberto Romero, Bo Hyun Yoon The Journal of Maternal-Fetal & Neonatal Medicine.2019; 32(4): 527. CrossRef - Discordance of Twin Placentas for Multifocal Eosinophilic/T-cell Chorionic Vasculitis
Erik W Nohr, James R Wright Pediatric and Developmental Pathology.2019; 22(1): 40. CrossRef - Differential immunophenotype of macrophages in acute and chronic chorioamnionitis
Go-Eun Bae, Joon-Seok Hong, Jung-Sun Kim, Ha Young Park, Ja Yun Jang, Yi Seul Kim, Suk-Joo Choi, Soo-young Oh, Cheong-Rae Roh Journal of Perinatal Medicine.2017;[Epub] CrossRef - Fetal death: an extreme manifestation of maternal anti-fetal rejection
Kia Lannaman, Roberto Romero, Tinnakorn Chaiworapongsa, Yeon Mee Kim, Steven J. Korzeniewski, Eli Maymon, Nardhy Gomez-Lopez, Bogdan Panaitescu, Sonia S. Hassan, Lami Yeo, Bo Hyun Yoon, Chong Jai Kim, Offer Erez Journal of Perinatal Medicine.2017;[Epub] CrossRef
- Morphologic Alteration of Metastatic Neuroblastic Tumor in Bone Marrow after Chemotherapy
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Go Eun Bae, Yeon-Lim Suh, Ki Woong Sung, Jung-Sun Kim
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Korean J Pathol. 2013;47(5):433-442. Published online October 25, 2013
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DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.433
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- Background
The aim of this study is to evaluate the histologic features of metastatic neuroblastic tumors (NTs) in bone marrow (BM) before and after chemotherapy in comparison with those of primary NTs. MethodsA total of 294 biopsies from 48 children diagnosed with NTs with BM metastasis were examined. There were 48 primary neoplasm biopsies, 48 BM biopsies before chemotherapy, 36 primary neoplasm excisional biopsies after chemotherapy, and 162 BM biopsies after chemotherapy. ResultsMetastatic NTs in BM before chemotherapy were composed of undifferentiated and/or differentiating neuroblasts, but had neither ganglion cells nor Schwannian stroma. Metastatic foci of BM after chemotherapy were found to have differentiated into ganglion cells or Schwannian stroma, which became more prominent after further cycles of chemotherapy. Persistence of NTs or tumor cell types in BM after treatment did not show statistically significant correlation to patients' outcome. However, three out of five patients who newly developed poorly differentiated neuroblasts in BM after treatment expired due to disease progression. ConclusionsMetastatic NTs in BM initially consist of undifferentiated or differentiating neuroblasts regardless of the primary tumor subtype, and become differentiated after chemotherapy. Newly appearing poorly differentiated neuroblasts after treatment might be an indicator for poor prognosis.
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- Postchemotherapy gross residual tumor in non‐high‐risk neuroblastoma: Clinical significance and the role of adjuvant therapy
Eun Seop Seo, Hana Lim, Hee Won Cho, Hee Young Ju, Ji Won Lee, Keon Hee Yoo, Sanghoon Lee, Do Hoon Lim, Ki Woong Sung, Hong Hoe Koo Pediatric Blood & Cancer.2022;[Epub] CrossRef
- Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination
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Go Eun Bae, Nara Yoon, Ha Young Park, Sang Yun Ha, Junhun Cho, Yunkyung Lee, Kyoung-Mee Kim, Cheol Keun Park
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Korean J Pathol. 2013;47(2):163-166. Published online April 24, 2013
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DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.163
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Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 µm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.
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- A Surgical Challenge Generated by Colonic Malakoplakia in Disguise as a Locally Advanced Colonic Malignancy—A Case Report
Cristina Șerban, Alexandra Toma, Dragoș Cristian Voicu, Constantin Popazu, Dorel Firescu, George Țocu, Raul Mihailov, Laura Rebegea Medicina.2023; 59(1): 156. CrossRef - Colonic malakoplakia in a cardiac transplant recipient: A case report
Sadiya Shafijan Indian Journal of Pathology and Microbiology.2020; 63(2): 322. CrossRef - Immunosuppressive drugs and the gastrointestinal tract in renal transplant patients
Merel M. Tielemans, Gerben A.J. van Boekel, Teun van Gelder, Eric T. Tjwa, Luuk B. Hilbrands Transplantation Reviews.2019; 33(2): 55. CrossRef - Malakoplakia of the colon following renal transplantation in a 73 year old woman: report of a case presenting as intestinal perforation
Andrew Mitchell, Alexandre Dugas Diagnostic Pathology.2019;[Epub] CrossRef - Colonic malakoplakia in a liver transplant recipient: A case report
Rana Ajabnoor, Mohammad Mawardi, Abdulmonem Almutawa Human Pathology: Case Reports.2019; 18: 200323. CrossRef - Malakoplakia after kidney transplantation: Case report and literature review
John Fredy Nieto-Ríos, Isabel Ramírez, Mónica Zuluaga-Quintero, Lina María Serna-Higuita, Federico Gaviria-Gil, Alejandro Velez-Hoyos Transplant Infectious Disease.2017; 19(5): e12731. CrossRef - Megalocytic Interstitial Nephritis Following Acute Pyelonephritis with Escherichia coli Bacteremia: A Case Report
Hee Jin Kwon, Kwai Han Yoo, In Young Kim, Seulkee Lee, Hye Ryoun Jang, Ghee Young Kwon Journal of Korean Medical Science.2015; 30(1): 110. CrossRef
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